Výsledky vyhledávání - "Ellis W.T. Wong"

The Raf/MEK/ERK pathway can govern drug resistance, apoptosis and sensitivity to targeted therapy

Autor: Ferdinando Nicoletti, James A. McCubrey, John G. Shelton, Jörg Bäsecke, Alberto M. Martelli, Stephen L. Abrams, Linda S. Steelman, William H. Chappell, Massimo Libra, Ellis W.T. Wong, Marco Donia, Franca Stivala

Publikováno v: Cell Cycle. 9:1781-1791

The effects of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways on proliferation, drug resistance, prevention of apoptosis and sensitivity to signal transduction inhibitors were examined in FL/DeltaAkt-1:ER*(Myr(+)) + DeltaRaf-1:AR cells whi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e94e1ec5539a00bfc80588ec68fc6cf6
https://doi.org/10.4161/cc.9.9.11483

Zobrazit plný text záznamu

Involvement of p53 and Raf/MEK/ERK pathways in hematopoietic drug resistance

Autor: Massimo Libra, Ferdinando Nicoletti, Ellis W.T. Wong, Sarah A Molton, Martin McMahon, James A. McCubrey, Giovanni Ligresti, Alberto M. Martelli, Negin Misaghian, Camilla Evangelisti, Jakob Troppmair, Jörg Bäsecke, Stephen L. Abrams, Linda S. Steelman

Publikováno v: Leukemia. 22:2080-2090

A cytokine-dependent (FL5.12), drug-sensitive, p53 wild type (WT) and a doxorubicin-resistant derivative line (FL/Doxo) were used to determine the mechanisms that could result in drug resistance of early hematopoietic precursor cells. Drug resistance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8043ab1743bb3f7a2f56f0056e770c6e
https://doi.org/10.1038/leu.2008.207

Zobrazit plný text záznamu

Involvement of Akt and mTOR in chemotherapeutic- and hormonal-based drug resistance and response to radiation in breast cancer cells

Autor: Ellis W.T. Wong, Lucio Cocco, Stephen L. Abrams, William H. Chappell, Patrick M. Navolanic, Linda S. Steelman, Lyudmyla Drobot, Richard A. Franklin, Massimo Libra, Ferdinando Nicoletti, Franca Stivala, Alberto M. Martelli, James A. McCubrey

Elucidating the response of breast cancer cells to chemotherapeutic and hormonal based drugs and radiation is clearly important as these are common treatment approaches. Signaling cascades often involved in chemo-, hormonal- and radiation resistance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b51b792a49b24651647207a83aedf6b0
http://hdl.handle.net/11585/110613

Zobrazit plný text záznamu

Suppression of PTEN function increases breast cancer chemotherapeutic drug resistance while conferring sensitivity to mTOR inhibitors

Autor: Franca Stivala, Ellis W.T. Wong, Jackson R. Taylor, Massimo Libra, Melissa L. Sokolosky, Linda S. Steelman, James A. McCubrey, David M. Terrian, Richard A. Franklin, Brian D. Lehmann, Patrick M. Navolanic, William H. Chappell, C. Alberto M. Martelli, Nick R. Leslie, Kristin Stadelman, Steven L. Abrams

Publikováno v: Oncogene. 27(29)

Ectopic expression of mutant forms of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) lacking lipid (G129E) or lipid and protein (C124S) phosphatase activity decreased sensitivity of MCF-7 breast cancer cells, which have wild-type PT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1903fc658882e26b165561b19b82b882
https://pubmed.ncbi.nlm.nih.gov/18332865

Zobrazit plný text záznamu

Alteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an achilles heel by sensitization to targeted therapy

The PI3K/PTEN/Akt/mTOR pathway plays critical roles in the regulation of cell growth. The effects of this pathway on drug resistance and cellular senescence of breast cancer cells has been a focus of our laboratory. Introduction of activated Akt or m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9711d7cfd259e892843bf48fafa4e08
https://hdl.handle.net/11380/1288403

Zobrazit plný text záznamu

Targeting Survival Cascades Induced by Activation of Ras/Raf/MEK/ERK and PI3K/Akt Pathways to Sensitize Cancer Cells to Therapy

Publikováno v: Sensitization of Cancer Cells for Chemo/Immuno/Radio-therapy ISBN: 9781934115299

The Ras/Raf/MEK/ERK pathway is activated by many growth factors and cytokines, which are important in driving proliferation and preventing apoptosis [1–5]. An overview of the effects of Ras/Raf/MEK/ERK and PI3K/Akt pathways on downstream signaling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3240785b23bcba3e98ce109ba2be84b6
https://doi.org/10.1007/978-1-59745-474-2_7

Zobrazit plný text záznamu

Targeting the RAF/MEK/ERK, PI3K/AKT and P53 pathways in hematopoietic drug resistance

Autor: Ellis W.T. Wong, Franca Stivala, Richard A. Franklin, Camilla Evangelisti, Massimo Libra, Linda S. Steelman, Brian D. Lehmann, Alberto M. Martelli, James A. McCubrey, David M. Terrian, Stephen L. Abrams, Jörg Bäsecke, William H. Chappell

hematopoietic drug resistance, acute myeloid leukemia, RAF/MEK/ERK pathway, PI3K/AKT pathway, P53 pathway

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b4c8b507ee0865e7249b1ed8ef6f32e
http://hdl.handle.net/20.500.11769/54655

Zobrazit plný text záznamu

Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance

Autor: Fumin Chang, Ellis W.T. Wong, Alberto M. Martelli, Brian D. Lehmann, Linda S. Steelman, Franca Stivala, Massimo Libra, Camilla Evangelisti, James A. McCubrey, Stephen L. Abrams, David M. Terrian, William H. Chappell, Richard A. Franklin, Michele Milella, Agostino Tafuri, Jörg Bäsecke

Publikováno v: Biochimica et biophysica acta. 1773(8)

Growth factors and mitogens use the Ras/Raf/MEK/ERK signaling cascade to transmit signals from their receptors to regulate gene expression and prevent apoptosis. Some components of these pathways are mutated or aberrantly expressed in human cancer (e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e23451b8cda6151d0f8bef99f92a515b
https://pubmed.ncbi.nlm.nih.gov/17126425

Zobrazit plný text záznamu

Key Roles of the Raf-1 and Akt in Drug Resistance, Cell Cycle Progression and the Prevention of Apoptosis in Hematopoietic Cells

Autor: Fred E. Bertrand, Steven L. Abrams, Ellis W.T. Wong, William H. Chappell, John G. Shelton, James A. McCubrey, Linda S. Steelman

Publikováno v: Blood. 106:1356-1356

The Raf/MEK/ERK and PI3K/Akt kinase cascades are pivotal in transmitting signals from membrane receptors to transcription factors which regulate growth, apoptosis and chemotherapeutic drug resistance. Previously we determined that activated Raf-1 or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0fcc21258e1f7a58780f2e2a5fe3542d
https://doi.org/10.1182/blood.v106.11.1356.1356

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání