Synovial fibroblasts assume distinct functional identities and secrete R-spondin 2 in osteoarthritis.

Autor: Knights AJ; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, Michigan, USA., Farrell EC; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, Michigan, USA.; Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA., Ellis OM; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, Michigan, USA., Lammlin L; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, Michigan, USA., Junginger LM; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, Michigan, USA., Rzeczycki PM; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, Michigan, USA., Bergman RF; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, Michigan, USA., Pervez R; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, Michigan, USA., Cruz M; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, Michigan, USA., Knight E; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, Michigan, USA., Farmer D; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, Michigan, USA., Samani AA; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, Michigan, USA., Wu CL; Department of Orthopaedic Surgery and Rehabilitation, University of Rochester, Rochester, New York, USA., Hankenson KD; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, Michigan, USA.; Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA., Maerz T; Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, Michigan, USA tmaerz@med.umich.edu.; Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA.

Publikováno v: Annals of the rheumatic diseases [Ann Rheum Dis] 2023 Feb; Vol. 82 (2), pp. 272-282. Date of Electronic Publication: 2022 Sep 29.

Signalling interaction between β‐catenin and other signalling molecules during osteoarthritis development.

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Applications of single-cell RNA sequencing in rheumatoid arthritis.

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Fibrotic pathways and fibroblastlike synoviocyte phenotypes in osteoarthritis.

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Identification of FOXO1 as a geroprotector in human synovium through single-nucleus transcriptomic profiling.

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