Zobrazeno 1 - 10
of 494
pro vyhledávání: '"Ellis L, Reinherz"'
Autor:
Kemin Tan, Junjian Chen, Yu Kaku, Yi Wang, Luke Donius, Rafiq Ahmad Khan, Xiaolong Li, Hannah Richter, Michael S. Seaman, Thomas Walz, Wonmuk Hwang, Ellis L. Reinherz, Mikyung Kim
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Broadly neutralizing antibodies (bnAbs) against HIV-1 target conserved envelope (Env) epitopes to block viral replication. Here, using structural analyses, we provide evidence to explain why a vaccine targeting the membrane-proximal external
Externí odkaz:
https://doaj.org/article/47bc63ae82264e1ca90081493607b6de
Publikováno v:
eLife, Vol 13 (2024)
Mechanical force is critical for the interaction between an αβ T cell receptor (TCR) and a peptide-bound major histocompatibility complex (pMHC) molecule to initiate productive T-cell activation. However, the underlying mechanism remains unclear. W
Externí odkaz:
https://doaj.org/article/8f049efe069f4a2bbef030ed71b32ca6
Autor:
Shuang Yang, Giorgos Hiotis, Yi Wang, Junjian Chen, Jia-huai Wang, Mikyung Kim, Ellis L. Reinherz, Thomas Walz
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The membrane-proximal external region of HIV-1 spike protein is a broadly neutralizing antibody target. Here, cryo-electron microscopy and molecular dynamics reveal spontaneous ectodomain tilting, a vulnerability exploitable for vaccine design.
Externí odkaz:
https://doaj.org/article/4c08e89bf0194f2f9406da998e62cf29
Autor:
Stina L. Wickström, Tanja Lövgren, Michael Volkmar, Bruce Reinhold, Jonathan S. Duke-Cohan, Laura Hartmann, Janina Rebmann, Anja Mueller, Jeroen Melief, Roeltje Maas, Maarten Ligtenberg, Johan Hansson, Rienk Offringa, Barbara Seliger, Isabel Poschke, Ellis L. Reinherz, Rolf Kiessling
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Tumor-infiltrating lymphocytes (TIL) are considered enriched for T cells recognizing shared tumor antigens or mutation-derived neoepitopes. We performed exome sequencing and HLA-A*02:01 epitope prediction from tumor cell lines from two HLA-A2-positiv
Externí odkaz:
https://doaj.org/article/a5d47d16c7624e0ba14d133d06de16b3
Autor:
Young D. Kwon, Gwo-Yu Chuang, Baoshan Zhang, Robert T. Bailer, Nicole A. Doria-Rose, Tatyana S. Gindin, Bob Lin, Mark K. Louder, Krisha McKee, Sijy O’Dell, Amarendra Pegu, Stephen D. Schmidt, Mangaiarkarasi Asokan, Xuejun Chen, Misook Choe, Ivelin S. Georgiev, Vivian Jin, Marie Pancera, Reda Rawi, Keyun Wang, Rajoshi Chaudhuri, Lisa A. Kueltzo, Slobodanka D. Manceva, John-Paul Todd, Diana G. Scorpio, Mikyung Kim, Ellis L. Reinherz, Kshitij Wagh, Bette M. Korber, Mark Connors, Lawrence Shapiro, John R. Mascola, Peter D. Kwong
Publikováno v:
Cell Reports, Vol 22, Iss 7, Pp 1798-1809 (2018)
Summary: Highly effective HIV-1-neutralizing antibodies could have utility in the prevention or treatment of HIV-1 infection. To improve the potency of 10E8, an antibody capable of near pan-HIV-1 neutralization, we engineered 10E8-surface mutants and
Externí odkaz:
https://doaj.org/article/20803a2ba97341ed985e9c54c91c448e
Autor:
Jonathan S. Duke-Cohan, Aoi Akitsu, Robert J. Mallis, Cameron M. Messier, Patrick H. Lizotte, Jon C. Aster, Wonmuk Hwang, Matthew J. Lang, Ellis L. Reinherz
Publikováno v:
Nature
Programming T lymphocytes to distinguish self from non-self is a vital, multi-step process arising in the thymus(1–4). Signalling through the pre-T cell receptor (preTCR), a CD3-associated heterodimer comprising an invariant pTα chain and a clone-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e7892b18e723adaf83475c6a15162d7
https://doi.org/10.1038/s41586-022-05555-7
https://doi.org/10.1038/s41586-022-05555-7
Autor:
Marta Gomez-Perosanz, Tara Fiyouzi, Miguel Fernandez-Arquero, John Sidney, Alessandro Sette, Ellis L. Reinherz, Esther M. Lafuente, Pedro A. Reche
Publikováno v:
Cells, Vol 10, Iss 9, p 2294 (2021)
Human rhinovirus (RV) is the most common cause of upper respiratory infections and exacerbations of asthma. In this work, we selected 14 peptides (6 from RV A and 8 from RV C) encompassing potential CD4 T cell epitopes. Peptides were selected for bei
Externí odkaz:
https://doaj.org/article/8e33b0dcd5ad44b9b668d6180e901bc5
Data from αβ TCR-Mediated Recognition: Relevance to Tumor-Antigen Discovery and Cancer Immunotherapy
Autor:
Ellis L. Reinherz
αβ T lymphocytes sense perturbations in host cellular body components induced by infectious pathogens, oncogenic transformation, or chemical or physical damage. Millions to billions of these lymphocytes are generated through T-lineage development i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::913d49305fbea840730bdf17e727e7f9
https://doi.org/10.1158/2326-6066.c.6548488.v1
https://doi.org/10.1158/2326-6066.c.6548488.v1
Autor:
David A. Barbie, Matthew G. Oser, Ellis L. Reinherz, Scott Rodig, Robin Edwards, Evisa Gjini, Pasi A. Jänne, Kathleen Pfaff, Michael Y. Tolstorukov, Lynette M. Sholl, Fangxin Hong, Benjamin Chen, Xi-Tao Wang, Ana Lako, Eliezer M. Van Allen, Mark M. Awad, Cloud P. Paweletz, Prafulla C. Gokhale, Brendan Reardon, Hideo Watanabe, Maya Fridrikh, Aoi Akitsu, Shunsuke Kitajima, Israel Cañadas, Takahiko Murayama, Alison D. Santucci, Victor Quadros, Andrew Portell, Patrick H. Lizotte, Luke J. Taus, Michael J. Poitras, Jonathan S. Duke-Cohan, Bruce B. Reinhold, Saemi Han, Brandon Piel, Tran C. Thai, Deli Hong, Marco Campisi, Maria Saigí, Amir Vajdi, Jacquelyn O. Wolff, Erik H. Knelson, Navin R. Mahadevan
Small cell lung carcinoma (SCLC) is highly mutated, yet durable response to immune checkpoint blockade (ICB) is rare. SCLC also exhibits cellular plasticity, which could influence its immunobiology. Here we discover that a distinct subset of SCLC uni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4647caa0d1c61ca9a140b00973df6824
https://doi.org/10.1158/2159-8290.c.6549244.v1
https://doi.org/10.1158/2159-8290.c.6549244.v1
Autor:
David A. Barbie, Matthew G. Oser, Ellis L. Reinherz, Scott Rodig, Robin Edwards, Evisa Gjini, Pasi A. Jänne, Kathleen Pfaff, Michael Y. Tolstorukov, Lynette M. Sholl, Fangxin Hong, Benjamin Chen, Xi-Tao Wang, Ana Lako, Eliezer M. Van Allen, Mark M. Awad, Cloud P. Paweletz, Prafulla C. Gokhale, Brendan Reardon, Hideo Watanabe, Maya Fridrikh, Aoi Akitsu, Shunsuke Kitajima, Israel Cañadas, Takahiko Murayama, Alison D. Santucci, Victor Quadros, Andrew Portell, Patrick H. Lizotte, Luke J. Taus, Michael J. Poitras, Jonathan S. Duke-Cohan, Bruce B. Reinhold, Saemi Han, Brandon Piel, Tran C. Thai, Deli Hong, Marco Campisi, Maria Saigí, Amir Vajdi, Jacquelyn O. Wolff, Erik H. Knelson, Navin R. Mahadevan
Supplementary Table S1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bdb01871ac4703e7fdf6229583a3de7
https://doi.org/10.1158/2159-8290.22540003.v1
https://doi.org/10.1158/2159-8290.22540003.v1