Zobrazeno 1 - 10
of 479
pro vyhledávání: '"Elliott Vichinsky"'
Autor:
Suzanne Braniecki, Elliott Vichinsky, Mark C. Walters, Shalini Shenoy, Qiuhu Shi, Theodore B. Moore, Julie-An Talano, Susan K. Parsons, Allyson Flower, Anne Panarella, Sandra Fabricatore, Erin Morris, Harshini Mahanti, Jordan Milner, Robert C. McKinstry, Christine N. Duncan, Carmella van de Ven, Mitchell S. Cairo
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
BackgroundDue to the risk of cerebral vascular injury, children and adolescents with high-risk sickle cell disease (SCD) experience neurocognitive decline over time. Haploidentical stem cell transplantation (HISCT) from human leukocyte antigen-matche
Externí odkaz:
https://doaj.org/article/1ffd73bb5fe045e7b11a68a31f21a4a3
Autor:
Chris A. Rees, David C. Brousseau, Daniel M. Cohen, Anthony Villella, Carlton Dampier, Kathleen Brown, Andrew Campbell, Corrie E. Chumpitazi, Gladstone Airewele, Todd Chang, Christopher Denton, Angela Ellison, Alexis Thompson, Fahd Ahmad, Nitya Bakshi, Keli D. Coleman, Sara Leibovich, Deborah Leake, Dunia Hatabah, Hagar Wilkinson, Michelle Robinson, T. Charles Casper, Elliott Vichinsky, Claudia R. Morris, the SCD Arginine Study Group and PECARN
Publikováno v:
Trials, Vol 24, Iss 1, Pp 1-15 (2023)
Abstract Background Despite substantial illness burden and healthcare utilization conferred by pain from vaso-occlusive episodes (VOE) in children with sickle cell disease (SCD), disease-modifying therapies to effectively treat SCD-VOE are lacking. T
Externí odkaz:
https://doaj.org/article/aa672f55e50b40d3a5683913eef538b1
Random Forest Clustering Identifies Three Subgroups of β-Thalassemia with Distinct Clinical Severity
Autor:
Angela Vitrano, Khaled M. Musallam, Antonella Meloni, Sebastiano Addario Pollina, Mehran Karimi, Amal El-Beshlawy, Mahmoud Hajipour, Vito Di Marco, Saqib Hussain Ansari, Aldo Filosa, Paolo Ricchi, Adriana Ceci, Shahina Daar, Efthymia Vlachaki, Sylvia Titi Singer, Zaki A. Naserullah, Alessia Pepe, Salvatore Scondotto, Gabriella Dardanoni, Fedele Bonifazi, Vijay G. Sankaran, Elliott Vichinsky, Ali T. Taher, Aurelio Maggio, International Working Group on Thalassemia (IWG-THAL)
Publikováno v:
Thalassemia Reports, Vol 12, Iss 1, Pp 14-23 (2022)
In this work, we aimed to establish subgroups of clinical severity in a global cohort of β-thalassemia through unsupervised random forest (RF) clustering. We used a large global dataset of 7910 β-thalassemia patients and evaluated 19 indicators of
Externí odkaz:
https://doaj.org/article/aa15c48822b849b987d37e3cf47bfde0
Autor:
Patrick B. Walter, Leah S. Hohman, Andrew Rokeby, Julian J. Lum, Robert Hagar, Lisa Lavrisha, Augusta Saulys, Frans A. Kuypers, Elliott Vichinsky, Claudia R. Morris
Publikováno v:
Complementary Therapies in Medicine, Vol 70, Iss , Pp 102856- (2022)
Objectives: L-Glutamine was FDA-approved for sickle cell disease (SCD) in 2017, yet the mechanism(s)-of-action are poorly understood. This study investigates the potential activation of autophagy as a previously unexplored mechanism-of-benefit. Desig
Externí odkaz:
https://doaj.org/article/560b1ca54ac24f2ea448737dead2bb32
Autor:
Khaled M. Musallam, Angela Vitrano, Antonella Meloni, Sebastiano Addario Pollina, Mehran Karimi, Amal El-Beshlawy, Mahmoud Hajipour, Vito Di Marco, Saqib Hussain Ansari, Aldo Filosa, Paolo Ricchi, Adriana Ceci, Shahina Daar, Efthymia Vlachaki, Sylvia Titi Singer, Zaki A. Naserullah, Alessia Pepe, Salvatore Scondotto, Gabriella Dardanoni, Fedele Bonifazi, Vijay G. Sankaran, Elliott Vichinsky, Ali T. Taher, Aurelio Maggio
Publikováno v:
Haematologica, Vol 106, Iss 9 (2021)
Externí odkaz:
https://doaj.org/article/f8aa168aaecb4973892659488df605a9
Autor:
Sylvia T. Singer, Roland Fischer, Isabel Allen, Ashutosh Lal, Elliott Vichinsky, Qing Yuan, Zhiyue J Wang
Publikováno v:
Haematologica, Vol 106, Iss 6 (2020)
Externí odkaz:
https://doaj.org/article/f25bd21800f44feb8b7218b57c657e12
Autor:
Shannon Kelly, Evan S Jacobs, Mars Stone, Sheila M Keating, Tzong-Hae Lee, Daniel Chafets, John Heitman, Melanie Dimapasoc, Eva Operskalski, Ward Hagar, Elliott Vichinsky, Michael P Busch, Philip J Norris, Brian Custer, Recipient Epidemiology and Donor Evaluation Study (REDS-III)
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0218880 (2020)
People with sickle cell disease (SCD) are reported to have low rates of HIV infection, slower progression to AIDS and lower HIV-associated mortality compared to the general population. Mechanisms of potential resistance to HIV in SCD are incompletely
Externí odkaz:
https://doaj.org/article/cf2e5f2095cc40c79070e2ba6fcd672f
Publikováno v:
Haematologica, Vol 98, Iss 6 (2013)
Non-transfusion-dependent thalassemias include a variety of phenotypes that, unlike patients with beta (β)-thalassemia major, do not require regular transfusion therapy for survival. The most commonly investigated forms are β-thalassemia intermedia
Externí odkaz:
https://doaj.org/article/4b7a2d3009514cc598e1aa7828f5b3e6
Autor:
Hugh Young Rienhoff, Vip Viprakasit, Lay Tay, Paul Harmatz, Elliott Vichinsky, Deborah Chirnomas, Janet L. Kwiatkowski, Amy Tapper, William Kramer, John B. Porter, Ellis J. Neufeld
Publikováno v:
Haematologica, Vol 96, Iss 4 (2011)
Background There is still a clinical need for a well-tolerated and safe iron chelator for the treatment of transfusional iron overload. We describe the pharmacokinetic properties and safety data after 7 days of dosing of FBS0701, a novel oral, once-d
Externí odkaz:
https://doaj.org/article/b1c11b6cc2594503b7938868a659bd08
Autor:
Paul Harmatz, Maureen M. Jonas, Janet L. Kwiatkowski, Elizabeth C. Wright, Roland Fischer, Elliott Vichinsky, Patricia J. Giardina, Ellis J. Neufeld, John Porter, Nancy Olivieri
Publikováno v:
Haematologica, Vol 93, Iss 8 (2008)
Antiviral treatment of hepatitis C virus in thalassemia has raised concerns of ribavirin-induced hemolysis and increased iron loading. This study examined the change in liver iron concentration, transfusion requirement, virological response, and iron
Externí odkaz:
https://doaj.org/article/107e5d20a0ad40a488f863f632b915e6