Zobrazeno 1 - 10 of 32 pro vyhledávání: '"Elliott P. Vichinsky"'
1
Akademický článek
Implications for the metabolic fate of oral glutamine supplementation within plasma and erythrocytes of patients with sickle cell disease: A pharmacokinetics study
Autor: Claudia R. Morris, Frans A. Kuypers, Robert Hagar, Sandra Larkin, Lisa Lavrisha, Augusta Saulys, Elliott P. Vichinsky, Jung H. Suh
Publikováno v: Complementary Therapies in Medicine, Vol 64, Iss , Pp 102803- (2022)
Objectives: L-Glutamine is FDA-approved for sickle cell disease (SCD), yet the mechanism(s)-of-action are poorly understood. We performed a pharmacokinetics (pK) study to determine the metabolic fate of glutamine supplementation on plasma and erythro
Externí odkaz: https://doaj.org/article/9bed86b6c7124eceb1325cd9253e7c0e
Zobrazit plný text záznamu
3
Akademický článek
Sildenafil therapy in thalassemia patients with Doppler-defined risk of pulmonary hypertension
Autor: Claudia R. Morris, Hae-Young Kim, John Wood, John B. Porter, Elizabeth S. Klings, Felicia L. Trachtenberg, Nancy Sweeters, Nancy F. Olivieri, Janet L. Kwiatkowski, Lisa Virzi, Sylvia T. Singer, Ali Taher, Ellis J. Neufeld, Alexis A. Thompson, Vandana Sachdev, Sandra Larkin, Jung H. Suh, Frans A. Kuypers, Elliott P. Vichinsky
Publikováno v: Haematologica, Vol 98, Iss 9 (2013)
Pulmonary hypertension is a common but often overlooked complication associated with thalassemia syndromes. There are limited data on the safety and efficacy of selective pulmonary vasodilators in this at-risk population. We, therefore, designed a 12
Externí odkaz: https://doaj.org/article/8cbedfd01cee4469b89b63927e5faa58
Zobrazit plný text záznamu
4
Akademický článek
A randomized, placebo-controlled trial of arginine therapy for the treatment of children with sickle cell disease hospitalized with vaso-occlusive pain episodes
Autor: Claudia R. Morris, Frans A. Kuypers, Lisa Lavrisha, Michael Ansari, Nancy Sweeters, Melinee Stewart, Ginny Gildengorin, Lynne Neumayr, Elliott P. Vichinsky
Publikováno v: Haematologica, Vol 98, Iss 9 (2013)
Painful episodes of vaso-occlusion are the leading cause of hospitalizations and emergency department visits in sickle cell disease, and are associated with increased mortality. Low nitric oxide bioavailability contributes to vasculopathy in sickle c
Externí odkaz: https://doaj.org/article/d926f271302449f0bab72bfa6e044298
Zobrazit plný text záznamu
7
Assessment of total and unbound cell-free heme in plasma of patients with sickle cell disease
Autor: Madhav Vissa, Sandra K Larkin, Elliott P Vichinsky, Frans A Kuypers, Eric Soupene
Publikováno v: Experimental Biology and Medicine. :153537022311579
Intravascular hemolysis results in the release of cell-free hemoglobin and heme in plasma. In sickle cell disease, the fragility of the sickle red blood cell leads to chronic hemolysis, which can contribute to oxidative damage and activation of infla
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ba622f323b819d610a76fc8d4fc40de9
https://doi.org/10.1177/15353702231157920
Zobrazit plný text záznamu
10
Safety and efficacy of mitapivat, an oral pyruvate kinase activator, in adults with non-transfusion dependent α-thalassaemia or β-thalassaemia: an open-label, multicentre, phase 2 study
Autor: Kevin H M Kuo, D Mark Layton, Ashutosh Lal, Hanny Al-Samkari, Joy Bhatia, Penelope A Kosinski, Bo Tong, Megan Lynch, Katrin Uhlig, Elliott P Vichinsky
Publikováno v: Lancet (London, England). 400(10351)
Patients with non-transfusion-dependent thalassaemia (NTDT), although they do not require regular blood transfusions for survival, can still accrue a heavy burden of comorbidities. No approved disease-modifying therapies exist for these patients. We
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fac65e659cd152bba3d8a5d0e26e5cde
https://pubmed.ncbi.nlm.nih.gov/36260990
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje