Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Elliott M Bernard"'
The antibiotic bedaquiline activates host macrophage innate immune resistance to bacterial infection
Autor:
Alexandre Giraud-Gatineau, Juan Manuel Coya, Alexandra Maure, Anne Biton, Michael Thomson, Elliott M Bernard, Jade Marrec, Maximiliano G Gutierrez, Gérald Larrouy-Maumus, Roland Brosch, Brigitte Gicquel, Ludovic Tailleux
Publikováno v:
eLife, Vol 9 (2020)
Antibiotics are widely used in the treatment of bacterial infections. Although known for their microbicidal activity, antibiotics may also interfere with the host’s immune system. Here, we analyzed the effects of bedaquiline (BDQ), an inhibitor of
Externí odkaz:
https://doaj.org/article/7742feb680244fcab351790b1c46fbe8
Autor:
Claudio Bussi, Tiaan Heunis, Enrica Pellegrino, Elliott M. Bernard, Nourdine Bah, Mariana Silva Dos Santos, Pierre Santucci, Beren Aylan, Angela Rodgers, Antony Fearns, Julia Mitschke, Christopher Moore, James I. MacRae, Maria Greco, Thomas Reinheckel, Matthias Trost, Maximiliano G. Gutierrez
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Extensive lysosomal damage can result in cell death but how limited protease leakage affects cytoplasmic organelles in viable cells is not well understood. Here the authors show that limited lysosomal damage leads to changes in the mitochondrial prot
Externí odkaz:
https://doaj.org/article/1b0eea4b126e4d9fbd71cb879e06a954
Autor:
Melissa Bedard, Sanne van der Niet, Elliott M. Bernard, Gregory Babunovic, Tan-Yun Cheng, Beren Aylan, Anita E. Grootemaat, Sahadevan Raman, Laure Botella, Eri Ishikawa, Mary P. O’Sullivan, Seónadh O’Leary, Jacob A. Mayfield, Jeffrey Buter, Adriaan J. Minnaard, Sarah M. Fortune, Leon O. Murphy, Daniel S. Ory, Joseph Keane, Sho Yamasaki, Maximiliano G. Gutierrez, Nicole van der Wel, D. Branch Moody
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 6 (2023)
Induction of lipid-laden foamy macrophages is a cellular hallmark of tuberculosis (TB) disease, which involves the transformation of infected phagolysosomes from a site of killing into a nutrient-rich replicative niche. Here, we show that a terpenyl
Externí odkaz:
https://doaj.org/article/66ad604010504fdab74173379c2c7ca6
Autor:
Pierre Santucci, Beren Aylan, Laure Botella, Elliott M. Bernard, Claudio Bussi, Enrica Pellegrino, Natalia Athanasiadi, Maximiliano G. Gutierrez
Publikováno v:
mBio, Vol 13, Iss 2 (2022)
ABSTRACT Mycobacterium tuberculosis segregates within multiple subcellular niches with different biochemical and biophysical properties that, upon treatment, may impact antibiotic distribution, accumulation, and efficacy. However, it remains unclear
Externí odkaz:
https://doaj.org/article/2c0c7d95b85240ef84d2a4ae39af13bd
Autor:
Elliott M. Bernard, Petr Broz
Publikováno v:
The Biochemical journal, vol. 479, no. 7, pp. 867-882
Following detection of pathogen infection and disrupted cellular homeostasis, cells can activate a range of cell death pathways, such as apoptosis, necroptosis and pyroptosis, as part of their defence strategy. The initiation of pro-inflammatory, lyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88c38416d3ad5e74cf3e2581f530a06c
https://doi.org/10.1042/bcj20220051
https://doi.org/10.1042/bcj20220051
Autor:
David Pires, Elliott M. Bernard, João Palma Pombo, Nuno Carmo, Catarina Fialho, Maximiliano Gabriel Gutierrez, Paulo Bettencourt, Elsa Anes
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
The success of tuberculosis (TB) bacillus, Mycobacterium tuberculosis (Mtb), relies on the ability to survive in host cells and escape to immune surveillance and activation. We recently demonstrated that Mtb manipulation of host lysosomal cathepsins
Externí odkaz:
https://doaj.org/article/131cacea20e4496f9e84e4cd234afb6f
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 7 (2017)
Strict spatiotemporal control of trafficking events between organelles is critical for maintaining homeostasis and directing cellular responses. This regulation is particularly important in immune cells for mounting specialized immune defenses. By co
Externí odkaz:
https://doaj.org/article/196721d77c0c4ab787952f4461478196
Autor:
Pierre Santucci, Beren Aylan, Laure Botella, Elliott M. Bernard, Claudio Bussi, Enrica Pellegrino, Natalia Athanasiadi, Maximiliano G. Gutierrez
SummaryThe intracellular population of Mycobacterium tuberculosis (Mtb) is dynamically segregated within multiple subcellular niches with different biochemical and biophysical properties that, upon treatment, may impact antibiotic distribution, accum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61abd354a72ed6233087d8bb6399f46b
https://doi.org/10.1101/2021.12.20.473466
https://doi.org/10.1101/2021.12.20.473466
Publikováno v:
Journal of Cell Science
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=r3c4b2081b22::882cca7471a9bdbfb636ef3a3a5ef72b
Autor:
Nicholas W. Wood, John Harvey, Huw R. Morris, Elliott M. Bernard, Maximiliano G. Gutierrez, Philip Campbell, Venizelos Papayannopoulos, Susanne Herbst
Publikováno v:
The EMBO Journal
Cells respond to endolysosome damage by either repairing the damage or targeting damaged endolysosomes for degradation via lysophagy. However, the signals regulating the decision for repair or lysophagy are poorly characterised. Here, we show that th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55725c5faaa16a3d581c91284c43b4a5
https://doi.org/10.15252/embj.2020104494
https://doi.org/10.15252/embj.2020104494