Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Elliott J. Hagedorn"'
Autor:
Vera Binder, Wantong Li, Muhammad Faisal, Konur Oyman, Donn L. Calkins, Jami Shaffer, Emily M. Teets, Steven Sher, Andrew Magnotte, Alex Belardo, William Deruelle, T. Charles Gregory, Shelley Orwick, Elliott J. Hagedorn, Julie R. Perlin, Serine Avagyan, Asher Lichtig, Francesca Barrett, Michelle Ammerman, Song Yang, Yi Zhou, William E. Carson, Heather R. Shive, James S. Blachly, Rosa Lapalombella, Leonard I. Zon, Bradley W. Blaser
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112528- (2023)
Summary: Altered hematopoietic stem cell (HSC) fate underlies primary blood disorders but microenvironmental factors controlling this are poorly understood. Genetically barcoded genome editing of synthetic target arrays for lineage tracing (GESTALT)
Externí odkaz:
https://doaj.org/article/b0783af216d541e48c1e8e6815eda5bc
Autor:
Lindsay N. Theodore, Elliott J. Hagedorn, Mauricio Cortes, Kelsey Natsuhara, Sarah Y. Liu, Julie R. Perlin, Song Yang, Madeleine L. Daily, Leonard I. Zon, Trista E. North
Publikováno v:
Stem Cell Reports, Vol 8, Iss 5, Pp 1226-1241 (2017)
Hematopoietic stem/progenitor cells (HSPCs) are formed during ontogeny from hemogenic endothelium in the ventral wall of the dorsal aorta (VDA). Critically, the cellular mechanism(s) allowing HSPC egress and migration to secondary niches are incomple
Externí odkaz:
https://doaj.org/article/7879a997547d4b23878d919f932b192d
Autor:
Margarita Parada-Kusz, Cristina Penaranda, Elliott J. Hagedorn, Anne Clatworthy, Anil V. Nair, Jonathan E. Henninger, Christoph Ernst, Brian Li, Raquel Riquelme, Humberto Jijon, Eduardo J. Villablanca, Leonard I. Zon, Deborah Hung, Miguel L. Allende
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 11 (2018)
Xenografts of the hematopoietic system are extremely useful as disease models and for translational research. Zebrafish xenografts have been widely used to monitor blood cancer cell dissemination and homing due to the optical clarity of embryos and l
Externí odkaz:
https://doaj.org/article/50d760aa5cb348a78f7c0c35aa0b8d98
Autor:
Samuel J. Wattrus, Mackenzie L. Smith, Cecilia Pessoa Rodrigues, Elliott J. Hagedorn, Ji Wook Kim, Bogdan Budnik, Leonard I. Zon
Publikováno v:
Science. 377:1413-1419
Tissue-specific stem cells persist for a lifetime and can differentiate to maintain homeostasis or transform to initiate cancer. Despite their importance, there are no described quality assurance mechanisms for newly formed stem cells. We observed in
Autor:
Elliott J. Hagedorn, Julie R. Perlin, Rebecca J. Freeman, Samuel J. Wattrus, Tianxiao Han, Clara Mao, Ji Wook Kim, Inés Fernández-Maestre, Madeleine L. Daily, Christopher D’Amato, Michael J. Fairchild, Raquel Riquelme, Brian Li, Dana A.V.E. Ragoonanan, Khaliun Enkhbayar, Emily L. Henault, Helen G. Wang, Shelby E. Redfield, Samantha H. Collins, Asher Lichtig, Song Yang, Yi Zhou, Balvir Kunar, Jesus Maria Gomez-Salinero, Thanh T. Dinh, Junliang Pan, Karoline Holler, Henry A. Feldman, Eugene C. Butcher, Alexander van Oudenaarden, Shahin Rafii, J. Philipp Junker, Leonard I. Zon
The hematopoietic niche is a supportive microenvironment composed of distinct cell types, including specialized vascular endothelial cells that directly interact with hematopoietic stem and progenitor cells (HSPCs). The molecular factors that specify
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14b90a91fb7a197e73cc3374b0f18cdb
http://edoc.mdc-berlin.de/23329/7/23329suppl.zip
http://edoc.mdc-berlin.de/23329/7/23329suppl.zip
Autor:
Isaac Adatto, Ying Wang, Stuart L. Schreiber, Leonard I. Zon, Lucas B. Sullivan, Raha Weigert, Chad A. Cowan, Bilguujin Dorjsuren, Partha P. Nag, Marlies P. Rossmann, Siegfried Hekimi, Ilaria Elia, Richard A. Young, Sejal Vyas, James Mullahoo, Julie R. Perlin, Curtis R. Warren, Brian J. Abraham, Alexander Meissner, Song Yang, Malvina Papanastasiou, Sara Hetzel, Victoria Chan, Karen Hoi, Marcia C. Haigis, Elliott J. Hagedorn, Eugenia Custo Greig, Steven A. Carr
Publikováno v:
Science
Metabolic pathway regulates cell fate Lineage-specific regulators direct cell fate decisions, but the precise mechanisms are not well known. Using an in vivo chemical suppressor screen of a bloodless zebrafish mutant, Rossmann et al. show that the li
Autor:
Michael J. Fairchild, Rebecca J. Freeman, Khaliun Enkhbayar, Samantha H. Collins, Samuel J. Wattrus, Eugene C. Butcher, Helen G. Wang, Jesus M. Gomez-Salinero, Elliott J. Hagedorn, Julie R. Perlin, Yi Zhou, Inés Fernández-Maestre, Brian Li, Christopher D’Amato, Emily L. Henault, Henry A. Feldman, Thanh Theresa Dinh, Alexander van Oudenaarden, Leonard I. Zon, Shelby E. Redfield, Raquel Riquelme, Shahin Rafii, Asher Lichtig, Song Yang, Karoline Holler, Junliang Pan, Clara Mao, Balvir Kunar, Tianxiao Han, Dana A.V.E. Ragoonanan, Ji Wook Kim, J. Philipp Junker, Madeleine L. Daily
The hematopoietic niche is a supportive microenvironment comprised of distinct cell types, including specialized vascular endothelial cells that directly interact with hematopoietic stem and progenitor cells (HSPCs). The molecular factors that specif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b26e49458391b494ac77ae49a8e22607
https://doi.org/10.1101/2021.11.03.467105
https://doi.org/10.1101/2021.11.03.467105
Autor:
Michelle I Lin, Emily N Price, Sonja Boatman, Elliott J Hagedorn, Eirini Trompouki, Sruthi Satishchandran, Charles W Carspecken, Audrey Uong, Anthony DiBiase, Song Yang, Matthew C Canver, Ann Dahlberg, Zhigang Lu, Cheng Cheng Zhang, Stuart H Orkin, Irwin D Bernstein, Jon C Aster, Richard M White, Leonard I Zon
Publikováno v:
eLife, Vol 4 (2015)
Angiopoietin-like proteins (angptls) are capable of ex vivo expansion of mouse and human hematopoietic stem and progenitor cells (HSPCs). Despite this intriguing ability, their mechanism is unknown. In this study, we show that angptl2 overexpression
Externí odkaz:
https://doaj.org/article/d413b0fa911d41d19654119779f21716
Autor:
Julie R. Perlin, Marsha A. Moses, Nur Mustafaoglu, Golnaz Morad, Leonard I. Zon, Tae-Eun Park, Cassandra C. Daisy, Elliott J. Hagedorn, Christopher V. Carman, Donald E. Ingber
Publikováno v:
ACS Nano. 13:13853-13865
The restrictive nature of the blood-brain barrier (BBB) creates a major challenge for brain drug delivery with current nanomedicines lacking the ability to cross the BBB. Extracellular vesicles (EVs) have been shown to contribute to the progression o
Autor:
Marlies P. Rossmann, Maurizio Fazio, Dorothee Bornhorst, Michael J. Fairchild, Avik Choudhuri, Leonard I. Zon, Jodi Weiss, Shannon Freyer, Audrey Sporrij, Iris T. Chan, Rodsy Modhurima, Julien Ablain, Meera Prasad, Hadley M Moreau, Margaret C. Weber, Meredith E. Stanhope, Elliott J. Hagedorn, Jason D. Boisvert, Julia Barbano, Serine Avagyan, Mackenzie Smith, Alicia M. McConnell, Rebecca J. Freeman
Publikováno v:
Cell. 184(7)
Many scientists spend unnecessary time reformatting papers to submit them to different journals. We propose a uniform submission format that we hope journals will include in their options for submission. Widespread adoption of this uniform submission