Transcriptional attenuation controls macrolide inducible efflux and resistance in Streptococcus pneumoniae and in other Gram-positive bacteria containing mef/mel(msr(D)) elements.

Autor: Scott T Chancey, Xianhe Bai, Nikhil Kumar, Elliott F Drabek, Sean C Daugherty, Thomas Colon, Sandra Ott, Naomi Sengamalay, Lisa Sadzewicz, Luke J Tallon, Claire M Fraser, Hervé Tettelin, David S Stephens

Publikováno v: PLoS ONE, Vol 10, Iss 2, p e0116254 (2015)

Macrolide resistance, emerging in Streptococcus pneumoniae and other Gram-positive bacteria, is increasingly due to efflux pumps encoded by mef/mel(msr) operons found on discrete mobile genetic elements. The regulation of mef/mel(msr) in these elemen

Externí odkaz: https://doaj.org/article/b8bdd95913d749d1877f89babe064cc0

Simultaneous transcriptional profiling of bacteria and their host cells.

Autor: Michael S Humphrys, Todd Creasy, Yezhou Sun, Amol C Shetty, Marcus C Chibucos, Elliott F Drabek, Claire M Fraser, Umar Farooq, Naomi Sengamalay, Sandy Ott, Huizhong Shou, Patrik M Bavoil, Anup Mahurkar, Garry S A Myers

Publikováno v: PLoS ONE, Vol 8, Iss 12, p e80597 (2013)

We developed an RNA-Seq-based method to simultaneously capture prokaryotic and eukaryotic expression profiles of cells infected with intracellular bacteria. As proof of principle, this method was applied to Chlamydia trachomatis-infected epithelial c

Externí odkaz: https://doaj.org/article/59def294e3484609874a64f23c588b1b

Capture-based enrichment of Theileria parva DNA enables full genome assembly of first buffalo-derived strain and reveals exceptional intra-specific genetic diversity

Autor: Vish Nene, Claudia Daubenberger, Richard P. Bishop, Roger Pelle, Kyle Tretina, Joana C. Silva, James B. Munro, Donald P. Knowles, Luke J. Tallon, W. Ivan Morrison, Jonathan Crabtree, Elliott F. Drabek, Hanzel T. Gotia, Elias Awino, Olukemi O. Ifeonu, Nicholas C. Palmateer, Joshua Orvis

Publikováno v: PLoS Neglected Tropical Diseases, Vol 14, Iss 10, p e0008781 (2020)
Palmateer, N C, Tretina, K, Orvis, J, Ifeonu, O O, Crabtree, J, Drabék, E, Pelle, R, Awino, E, Gotia, H T, Munro, J B, Tallon, L, Morrison, W I, Daubenberger, C A, Nene, V, Knowles, D P, Bishop, R P & Silva, J C 2020, ' Capture-based enrichment of Theileria parva DNA enables full genome assembly of first buffalo-derived strain and reveals exceptional intra-specific genetic diversity ', PLoS Neglected Tropical Diseases, vol. 14, no. 10, pp. e0008781 . https://doi.org/10.1371/journal.pntd.0008781
PLoS Neglected Tropical Diseases

Theileria parva is an economically important, intracellular, tick-transmitted parasite of cattle. A live vaccine against the parasite is effective against challenge from cattle-transmissible T. parva but not against genotypes originating from the Afr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::889fe311928178dd76c6733538bad24b
https://doaj.org/article/8f70a77d240e4115906cbd29836599c8

Strains used in whole organism Plasmodium falciparum vaccine trials differ in genome structure, sequence, and immunogenic potential

Autor: David L. Saunders, Antoine Dara, Sergey Koren, Jonathan Crabtree, Emily M Stucke, B. Kim Lee Sim, Matthew Adams, Tao Li, Michele D. Spring, Krisada Jongsakul, Luke J. Tallon, Robert W. Sauerwein, Miriam K. Laufer, Amed Ouattara, Claire M. Fraser, Mark A. Travassos, Priscila T. Rodrigues, Marcelo U. Ferreira, Lisa Sadzewicz, Kara A. Moser, Christopher V. Plowe, Kirsten E. Lyke, Shannon Takala-Harrison, Chanthap Lon, Elliott F. Drabek, Adam M. Phillippy, Myaing M. Nyunt, Ankit Dwivedi, Stephen L. Hoffman, Joana C. Silva, Zalak Shah

BackgroundPlasmodium falciparum(Pf) whole-organism sporozoite vaccines have provided excellent protection against controlled human malaria infection (CHMI) and naturally transmitted heterogeneous Pf in the field. Initial CHMI studies showed significa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9de0bc3979b02e7d0cadfd5106e7f344

A new method for sequencing the hypervariable Plasmodium falciparum gene var2csa from clinical samples

Autor: Antoine Dara, Matthew Adams, Sonia Agrawal, Joana C. Silva, Elliott F. Drabek, Mark A. Travassos, Christopher V. Plowe, Sarah Schaffer DeRoo, Miriam K. Laufer

Publikováno v: Malaria Journal, Vol 16, Iss 1, Pp 1-9 (2017)
Malaria Journal

Background VAR2CSA, a member of the Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family, mediates the binding of P. falciparum-infected erythrocytes to chondroitin sulfate A, a surface-associated molecule expressed in placental cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3635d59145a22ef93b79246b69c336b2
https://doi.org/10.1186/s12936-017-1976-8