Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Elliott B. Jones"'
Autor:
Wenkui Li, Jeffrey D. Miller, Jimmy Flarakos, Yuan-Qing Xia, Yunlin Fu, Francis L. S. Tse, Elliott B. Jones
Publikováno v:
Analytical Chemistry. 88:3655-3661
A differential mobility spectrometry (DMS) in combination with a multiple ion monitoring (MIM) method was developed and validated for quantitative LC-MS/MS bioanalysis of pasireotide (SOM230) in human plasma. Pasireotide, a therapeutic cyclic peptide
Publikováno v:
Journal of the American Society for Mass Spectrometry. 23:964-976
Drugs can be metabolically activated to soft and hard electrophiles, which are readily trapped by glutathione (GSH) and cyanide (CN), respectively. These adducts are often detected and structurally characterized using separate tandem mass spectrometr
Autor:
Timothy W. Lovenberg, Ying Qu, Xiaohui Jiang, Christopher King, Leah Aluisio, Loren Y. Olson, Elliott B. Jones
Publikováno v:
Tandem Mass Spectrometry-Applications and Principles
Pharmacokinetic (PK) characterization and in vivo pharmacological properties of new chemical entities are important components during lead compound selection and optimization in the drug discovery process. Accordingly, reliable techniques are needed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67aed517e0298750905ef1a097813e5d
https://doi.org/10.5772/33100
https://doi.org/10.5772/33100
Publikováno v:
Mass Spectrometry in Drug Metabolism and Disposition: Basic Principles and Applications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0511ea4c677c59cc0385319a3deed6c
https://doi.org/10.1002/9780470929278.ch15
https://doi.org/10.1002/9780470929278.ch15
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 40(8)
The involvement of cytochrome P450 2B6 (CYP2B6) to the in vitro and in vivo metabolism of bupropion has been well studied. In these investigations we performed a detailed in vitro phenotyping study to characterize isoforms other than CYP2B6. A total
Quadrupole, Triple-Quadrupole, and Hybrid Linear Ion Trap Mass Spectrometers for Metabolite Analysis
Autor:
Elliott B. Jones
Publikováno v:
Mass Spectrometry in Drug Metabolism and Pharmacokinetics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7668ab9307d3af9a582a0b1cf52a0273
https://doi.org/10.1002/9780470409817.ch3
https://doi.org/10.1002/9780470409817.ch3