Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Elliott B. Grossbard"'
Publikováno v:
British Journal of Clinical Pharmacology. 76:78-88
Aim Fostamatinib (R788) is an orally dosed prodrug designed to deliver the active metabolite R940406 (R406), a spleen tyrosine kinase (SYK) inhibitor, for the treatment of rheumatoid arthritis. The objectives were to evaluate the human pharmacokineti
Autor:
Elliott B. Grossbard, Theresa K. Musser, Michael E. Weinblatt, David Jones, Daniel B. Magilavy, Mark C. Genovese, Arthur Kavanaugh
Publikováno v:
The Journal of Rheumatology. 40:369-378
Objective.To assess the influence of fostamatinib on patient-reported outcomes (PRO) in patients with active rheumatoid arthritis and an inadequate response to methotrexate (MTX).Methods.Patients taking background MTX (N = 457) were enrolled in a pha
Autor:
Paul D. Martin, Clive Brealey, Tim Mant, David J. Sweeny, Kelli Craven, Elliott B. Grossbard, Stuart Oliver, David Millson, Muhammad Baluom, David Lau, Michael Gillen
Publikováno v:
Drugs in R&D
Background Fostamatinib (R788) is a spleen tyrosine kinase (SYK) inhibitor. The active metabolite of fostamatinib, R406, is primarily metabolized by CYP3A4. Objectives The aim of this study was to characterize hepatic microsomal metabolism of R406 an
Autor:
Jeffrey Clough, Elliott B. Grossbard, Gary Park, David Lau, Somasekhar Bhamidipati, Weiqun Li, Rajinder Singh, Muhammad Baluom, David J. Sweeny
Publikováno v:
Drug Metabolism and Disposition. 38:1166-1176
The metabolism of the spleen tyrosine kinase inhibitor N4-(2,2-dimethyl-3-oxo-4-pyrid[1,4]oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethyoxyphenyl)-2,4-pyrimidinediamine (R406) and its oral prodrug N4-(2,2-dimethyl-4-[(dihydrogenphosphonoxy)methyl]-3-oxo-5-
Autor:
Arvinder Sran, Kunbin Qu, Sambaiah Thota, David L. Carroll, Sacha Holland, Tarikere Gururaja, Christian Franci, Vanessa Taylor, D. Wayne Lang, Yonchu Jenkins, Rajinder Singh, George Clemens, Muhammad Baluom, Caroline M. R. Low, Elliott B. Grossbard, Steve Wong, Taisei Kinoshita, Donald G. Payan, Joe Lasaga, John R. McLaughlin, Ankush Argade, Angela Romane, Yanhong Zhu, Betty Chang, David J. Sweeny, Hui Li, Weiduan Xu, Yasumichi Hitoshi, Manjeet Parmer, Polly Pine, Vadim Markovtsov, Feifei Zhao, Erlina Pali, Marina Gelman
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 136:99-113
Aurora kinases play a key role in mitotic progression. Over-expression of Aurora kinases is found in several human cancers and correlated with histological malignancy and clinical outcomes. Therefore, Aurora kinase inhibitors should be useful in the
Autor:
Gabriel Medrano-Ramírez, J. Morales-Torres, Ruben Burgos-Vargas, Nicholas Straniero, Elliott B. Grossbard, Ara Dikranian, Michael E. Weinblatt, Angela V. Vicente-Gonzales, Theresa K. Musser, Frederick T. Murphy, Arthur Kavanaugh
Publikováno v:
Arthritis & Rheumatism. 58:3309-3318
Objective Spleen tyrosine kinase (Syk) has been identified as an important modulator of immune signaling in B cells and cells bearing Fcγ-activating receptors. R788, a prodrug of active metabolite R406, has been shown to be an inhibitor of Syk kinas
Autor:
Donald G. Payan, Elliott B. Grossbard, Feifei Zhao, Su Wang, Nathan Schoettler, Ernest Brahn, Angela Lau, Mona Lisa Banquerigo, Betty Chang, Polly Pine
Publikováno v:
Clinical Immunology. 124:244-257
Spleen tyrosine kinase (Syk), a key mediator of immunoreceptor signaling in inflammatory cells, is essential for immune complex-mediated signal transduction initiated by activated receptors for immunoglobulin G. In collagen-induced arthritis, R788/R4
Publikováno v:
Expert Opinion on Investigational Drugs. 13:743-762
Recent advances in our understanding of allergic and autoimmune disorders have begun to translate into novel, effective and safe medicines for these common maladies. Examples include an anti-IgE monoclonal antibody recently approved for severe asthma
Publikováno v:
Journal of Allergy and Clinical Immunology. 119:1277-1279
Autor:
C. Bott-Silverman, Leslie W Miller, Robert E. Hobbs, Elliott B. Grossbard, Gustavo Rincon, Karen B. James
Publikováno v:
The American Journal of Cardiology. 78:896-901
Synthetic human brain natriuretic peptide (sBNP) is a polypeptide with the same amino acid sequence as the naturally occurring hormone. Preclinical studies have demonstrated that BNP has potent hemodynamic, diuretic, and natriuretic effects that migh