Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Elliott, Christina Louise"'
Autor:
Glennon, Elizabeth Bernadette Claire, Lau, Hay Wun Dawn, Gabriele, Rebecca Maria Cecilia, Taylor, Matthew, Troakes, Claire, Opie-Martin, Sarah, Elliott, Christina Louise, Killick, Richard, Hanger, Diane Pamela, Gomez Perez-Nievas, Beatriz, Noble, Wendy Jane
Publikováno v:
Glennon, E B C, Lau, H W D, Gabriele, R M C, Taylor, M, Troakes, C, Opie-Martin, S, Elliott, C L, Killick, R, Hanger, D P, Gomez Perez-Nievas, B & Noble, W J 2020, ' Loss of BIN1 protein in Alzheimer’s disease promotes synaptic accumulation of phosphorylated tau and disrupts tau release : Tau-directed effects of BIN1 loss in AD ', Brain Communications, vol. 2(1):fcaa011 . https://doi.org/10.1093/braincomms/fcaa011
Polymorphisms associated with BIN1 confer the second greatest risk for developing late onset Alzheimer’s disease. The biological consequences of this genetic variation are not fully understood, however BIN1 is a binding partner for tau. Tau is norm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2761::5e0a87198f4463b9485f51a5498b9368
https://kclpure.kcl.ac.uk/ws/files/122129704/Manuscript_Glennon_et_al.pdf
https://kclpure.kcl.ac.uk/ws/files/122129704/Manuscript_Glennon_et_al.pdf
Autor:
Elliott, Christina Louise, Rojo, Ana I, Ribe, Elena, Broadstock, Martin, Xia, Weiming, Mornin, Peter, Semenov, mMikhail, Baillie, George, Cuadrado, Antonio, Al-Shawi, Raya, Ballard, Clive Gerald, Simons, Paul, Killick, Richard
Publikováno v:
Elliott, C L, Rojo, A I, Ribe, E, Broadstock, M, Xia, W, Mornin, P, Semenov, MM, Baillie, G, Cuadrado, A, Al-Shawi, R, Ballard, C G, Simons, P & Killick, R 2018, ' A role for APP in Wnt signalling links synapse loss with β-amyloid production : Aβ synaptotoxicity drives Aβ production ', Translational psychiatry, vol. 8, no. 1, 179 . https://doi.org/10.1038/s41398-018-0231-6
In Alzheimer’s disease (AD), the canonical Wnt inhibitor Dickkopf-1 (Dkk1) is induced by β-amyloid (Aβ) and shifts the balance from canonical towards non-canonical Wnt signalling. Canonical (Wnt-β-catenin) signalling promotes synapse stability,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2761::e60324fbda4fd9452dab507f1fd82a0b
https://kclpure.kcl.ac.uk/ws/files/147552094/A_role_for_APP_in_Wnt_signalling_links_KILLICK_Publishedonline20September2018_GOLD_VoR_CC_BY_.pdf
https://kclpure.kcl.ac.uk/ws/files/147552094/A_role_for_APP_in_Wnt_signalling_links_KILLICK_Publishedonline20September2018_GOLD_VoR_CC_BY_.pdf