Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Elliot S. Ballato"'
Autor:
Yasaman Barekatain, Jeffrey J. Ackroyd, Victoria C. Yan, Sunada Khadka, Lin Wang, Ko-Chien Chen, Anton H. Poral, Theresa Tran, Dimitra K. Georgiou, Kenisha Arthur, Yu-Hsi Lin, Nikunj Satani, Elliot S. Ballato, Eliot I. Behr, Ana C. deCarvalho, Roel G. W. Verhaak, John de Groot, Jason T. Huse, John M. Asara, Raghu Kalluri, Florian L. Muller
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The metabolite methylthioadenosine (MTA) inhibits PRMT5. Therefore, MTA accumulation due to MTA phosphorylase (MTAP) deletion has been proposed as a vulnerability for PRMT5-targeted therapy in cancer. Here, the authors show that MTA does not accumula
Externí odkaz:
https://doaj.org/article/52cd1479712f4a068ae698d7e4c9858e
Autor:
Victoria C. Yan, Cong-Dat Pham, Elliot S. Ballato, Kristine L. Yang, Kenisha Arthur, Sunada Khadka, Yasaman Barekatain, Prakriti Shrestha, Theresa Tran, Anton H. Poral, Mykia Washington, Sudhir Raghavan, Barbara Czako, Federica Pisaneschi, Yu-Hsi Lin, Nikunj Satani, Naima Hammoudi, Jeffrey J. Ackroyd, Dimitra K. Georgiou, Steven W. Millward, Florian L. Muller
Publikováno v:
Journal of Medicinal Chemistry. 65:13813-13832
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c565c90ba8203219ba3e0da6dae7456
https://doi.org/10.1021/acs.jmedchem.2c01039
https://doi.org/10.1021/acs.jmedchem.2c01039
Autor:
Victoria C. Yan, Cong-Dat Pham, Elliot S. Ballato, Kristine L. Yang, Sunada Khadka, Yasaman Barektain, Prakriti Shrestha, Theresa Tran, Anton H. Poral, Mykia Washington, Sudhir Raghavan, Barbara Czako, Federica Pisaneschi, Yu-Hsi Lin, Nikunj Satani, Naima Hammoudi, Jeffrey J. Ackroyd, Dimitra K. Georgiou, Steven W. Millward, Florian L. Muller
Publikováno v:
Cancer Research. 83:3097-3097
Cancers harboring homozygous deletion of the glycolytic enzyme enolase 1 (ENO1) are selectively vulnerable to inhibition of the paralogous isoform, enolase 2 (ENO2). We previously identified and characterized a competitive, small molecule phosphonate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a76ebf1b8e0029263b0896f4bcfec6a5
https://doi.org/10.1158/1538-7445.am2023-3097
https://doi.org/10.1158/1538-7445.am2023-3097
Autor:
Kenisha Arthur, John M. Asara, Anton H. Poral, Nikunj Satani, Yu Hsi Lin, Raghu Kalluri, Florian L. Muller, Sunada Khadka, Dimitra K. Georgiou, Theresa Tran, Jeffrey J. Ackroyd, Jason T. Huse, Victoria C. Yan, Yasaman Barekatain, Eliot Itzkow Behr, Lin Wang, Ana C. deCarvalho, Ko Chien Chen, Elliot S. Ballato, John de Groot, Roel G.W. Verhaak
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
Homozygous deletion of methylthioadenosine phosphorylase (MTAP) in cancers such as glioblastoma represents a potentially targetable vulnerability. Homozygous MTAP-deleted cell lines in culture show elevation of MTAP’s substrate metabolite, methylth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9d9f6704f02c6b5337184c4f7765ff2
https://doaj.org/article/52cd1479712f4a068ae698d7e4c9858e
https://doaj.org/article/52cd1479712f4a068ae698d7e4c9858e
Autor:
Theresa Tran, Cong-Dat Pham, Anton H. Poral, Florian L. Muller, Elliot S. Ballato, Mykia Washington, Kenisha Arthur, Dimitra K. Georgiou, Prakriti Shrestha, Victoria C. Yan, Sunada Khadka, Kristine L. Yang, Matthew J. Yan
Publikováno v:
ACS Med Chem Lett
[Image: see text] Glycolysis inhibition remains aspirational in cancer therapy. We recently described a promising phosphonate inhibitor of enolase for cancers harboring homozygous deletions of ENO1. Here, we describe the application of a nitroheteroc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a30588b038d854fa78430e16366cd14f
https://europepmc.org/articles/PMC7357215/
https://europepmc.org/articles/PMC7357215/
Autor:
Dimitra K. Georgiou, Victoria C. Yan, Florian L. Muller, Kristine L. Yang, Kenisha Arthur, Elliot S. Ballato
Glycolysis inhibition remains aspirational in cancer therapy. We recently described a promising phosphonate inhibitor of Enolase for cancers harboring deletions in ENO1. Here, we describe the application of nitroheterocycle pro-drugs capitalizing on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c263bedcf5b1eae09223a21edcb482af
https://doi.org/10.26434/chemrxiv.12033303.v1
https://doi.org/10.26434/chemrxiv.12033303.v1
Autor:
Ana C. deCarvalho, Kenisha Arthur, Anton H. Poral, John M. Asara, Nikunj Satani, Yu Hsi Lin, John de Groot, Dimitra K. Georgiou, Theresa Tran, Roeland Verhaak, Victoria C. Yan, Jeffrey J. Ackroyd, Jason T. Huse, Yasaman Barekatain, Florian L. Muller, Elliot S. Ballato
In BriefThe co-deletion ofMTAPin theCDKN2Alocus is a frequent event in diverse cancers including glioblastoma. Recent publications report that significant accumulations of the MTAP substrate, methylthioadenosine (MTA), can sensitizeMTAP-deleted cance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5104540bcb859cd8d69fbc9e6da838e
Autor:
Kenisha Arthur, Florian L. Muller, Elliot S. Ballato, Pakriti Shrestha, Jeffrey J. Ackroyd, Sunada Khadka, Kristine L. Yang, Dimitra K. Georgiou, Victoria C. Yan
Publikováno v:
Cancer Research. 79:984-984
Background: Precision oncology is currently restricted to activated oncogenes as drug targets, with tumor suppressor deletions remaining largely in-actionable. We developed a novel method that targets tumor suppressor deletions by exploiting vulnerab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e6c11d9177fb6c62283769fbc680d16
https://doi.org/10.1158/1538-7445.am2019-984
https://doi.org/10.1158/1538-7445.am2019-984
Autor:
Barekatain, Yasaman, Ackroyd, Jeffrey J., Yan, Victoria C., Khadka, Sunada, Wang, Lin, Chen, Ko-Chien, Poral, Anton H., Tran, Theresa, Georgiou, Dimitra K., Arthur, Kenisha, Lin, Yu-Hsi, Satani, Nikunj, Ballato, Elliot S., Behr, Eliot I., deCarvalho, Ana C., Verhaak, Roel G. W., de Groot, John, Huse, Jason T., Asara, John M., Kalluri, Raghu
Publikováno v:
Nature Communications; 7/9/2021, Vol. 12 Issue 1, p1-13, 13p