Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Elliot A. Drobetsky"'
Autor:
Jean-François Lemay, Edlie St-Hilaire, Daryl A Ronato, Yuandi Gao, François Bélanger, Sari Gezzar-Dandashi, Aimé Boris Kimenyi Ishimwe, Christina Sawchyn, Dominique Lévesque, Mary McQuaid, François-Michel Boisvert, Frédérick A Mallette, Jean-Yves Masson, Elliot A Drobetsky, Hugo Wurtele
Publikováno v:
PLoS Biology, Vol 20, Iss 10, p e3001543 (2022)
Helix-destabilizing DNA lesions induced by environmental mutagens such as UV light cause genomic instability by strongly blocking the progression of DNA replication forks (RFs). At blocked RF, single-stranded DNA (ssDNA) accumulates and is rapidly bo
Externí odkaz:
https://doaj.org/article/a406ab3b3aab4c1790f2cb75bdd9eeda
Autor:
Mathieu Neault, Charles-Étienne Lebert-Ghali, Marilaine Fournier, Caroline Capdevielle, Elizabeth A.R. Garfinkle, Alyssa Obermayer, Anitria Cotton, Karine Boulay, Christina Sawchyn, Kamy H. Nguyen, Béatrice Assaf, François E. Mercier, Jean-Sébastien Delisle, Elliot A. Drobetsky, Laura Hulea, Timothy I. Shaw, Johannes Zuber, Tanja A. Gruber, Heather J. Melichar, Frédérick A. Mallette
Pediatric acute megakaryoblastic leukemia (AMKL) is an aggressive, uncurable blood cancer associated with poor therapeutic response and high mortality. We developed CBFA2T3-GLIS2-driven mouse models of AMKL that recapitulate the phenotypic and transc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97f49e34346fda3cc52cee24850c699a
https://doi.org/10.1101/2022.12.16.520129
https://doi.org/10.1101/2022.12.16.520129
Autor:
Jean-François Lemay, Edlie St-Hilaire, Sari Gezzar-Dandashi, Mary McQuaid, Daryl A. Ronato, Yuandi Gao, François Bélanger, Christina Sawchyn, Aimé Boris Kimenyi Ishimwe, Frédérick A. Mallette, Jean-Yves Masson, Elliot A. Drobetsky, Hugo Wurtele
Helix-destabilizing DNA lesions induced by environmental mutagens such as UV light cause genomic instability by strongly blocking the progression of DNA replication forks (RF). At blocked RF, single-stranded DNA (ssDNA) accumulates and is rapidly bou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd1e1f02b03a3fc4f27e925c303f17a3
https://doi.org/10.1101/2022.01.17.476707
https://doi.org/10.1101/2022.01.17.476707
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85294 (2014)
It is well established that efficient removal of highly-promutagenic UV-induced dipyrimidine photoproducts via nucleotide excision repair (NER) is required for protection against sunlight-associated malignant melanoma. Nonetheless, the extent to whic
Externí odkaz:
https://doaj.org/article/80bc93d2f4934033b18d593687177b7f
Autor:
Ian Hammond-Martel, Helen Pak, Helen Yu, Raphael Rouget, Andrew A Horwitz, Jeffrey D Parvin, Elliot A Drobetsky, El Bachir Affar
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e14027 (2010)
The function of BRCA1 in response to ionizing radiation, which directly generates DNA double strand breaks, has been extensively characterized. However previous investigations have produced conflicting data on mutagens that initially induce other cla
Externí odkaz:
https://doaj.org/article/71ebaf2397b44b62b44bdde2c71e36cc
Autor:
Elliot A. Drobetsky, Barry W. Glickman
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 232:281-289
A system for studying mutational specificity at a heterozygous locus in Chinese hamster ovary (CHO) cells in described. The strategy employed is based on restriction fragment analysis and DNA sequencing of enzymatically amplified mutant adenine phosp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73dbc8e082412552ca7e60ba9dad07c4
https://doi.org/10.1016/0027-5107(90)90135-q
https://doi.org/10.1016/0027-5107(90)90135-q
Publikováno v:
Mutation Research/Reviews in Genetic Toxicology. 220:235-240
Mutational spectra have become increasingly important tools in generating a molecular level understanding of mutagenesis in mammalian cells. The work in this field has primarily involved the use of shuttle vector systems although some work has also b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3070ec7cca4e2627ebdd4a541761ee24
https://doi.org/10.1016/0165-1110(89)90027-4
https://doi.org/10.1016/0165-1110(89)90027-4
Publikováno v:
Mutation Research Letters. 226:239-244
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::102a335603c894e640265b49d70f797d
https://doi.org/10.1016/0165-7992(89)90076-6
https://doi.org/10.1016/0165-7992(89)90076-6