Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Ellinor I. Peerschke"'
Autor:
Annika Sünderhauf, Maren Hicken, Heidi Schlichting, Kerstin Skibbe, Mohab Ragab, Annika Raschdorf, Misa Hirose, Holger Schäffler, Arne Bokemeyer, Dominik Bettenworth, Anne G. Savitt, Sven Perner, Saleh Ibrahim, Ellinor I. Peerschke, Berhane Ghebrehiwet, Stefanie Derer, Christian Sina
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 1, Pp 229-250 (2021)
Background & Aims: Cell differentiation in the colonic crypt is driven by a metabolic switch from glycolysis to mitochondrial oxidation. Mitochondrial and goblet cell dysfunction have been attributed to the pathology of ulcerative colitis (UC). We hy
Externí odkaz:
https://doaj.org/article/3c9778069d6f49cc96087014960b017d
Autor:
Anne G. Savitt, Samantha Manimala, Tiara White, Marina Fandaros, Wei Yin, Huiquan Duan, Xin Xu, Brian V. Geisbrecht, David A. Rubenstein, Allen P. Kaplan, Ellinor I. Peerschke, Berhane Ghebrehiwet
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Infection with SARS-CoV-2 triggers the simultaneous activation of innate inflammatory pathways including the complement system and the kallikrein-kinin system (KKS) generating in the process potent vasoactive peptides that contribute to severe acute
Externí odkaz:
https://doaj.org/article/6770e2f74e8948b8a62d2b8fa28fe7c4
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
BackgroundCOVID-19 pathology is associated with exuberant inflammation, vascular damage, and activation of coagulation. In addition, complement activation has been described and is linked to disease pathology. However, few studies have been conducted
Externí odkaz:
https://doaj.org/article/903fe8b394e74c798df6ce851957ecb1
Autor:
Annika Raschdorf, Annika Sünderhauf, Kerstin Skibbe, Berhane Ghebrehiwet, Ellinor I. Peerschke, Christian Sina, Stefanie Derer
Publikováno v:
Frontiers in Oncology, Vol 10 (2021)
Rapid proliferation of cancer cells is enabled by favoring aerobic glycolysis over mitochondrial oxidative phosphorylation (OXPHOS). P32 (C1QBP/gC1qR) is essential for mitochondrial protein translation and thus indispensable for OXPHOS activity. It i
Externí odkaz:
https://doaj.org/article/c0e6039d992e48e782be4ae85be3b831
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Genetic deficiency in C1q is a strong susceptibility factor for systemic lupus erythematosus (SLE). There are two major hypotheses that potentially explain the role of C1q in SLE. The first postulates that C1q deficiency abrogates apoptotic cell clea
Externí odkaz:
https://doaj.org/article/5a22f3eac8e54fb38584e634dcea26c7
Autor:
Ellinor I. Peerschke, Elisa de Stanchina, Qing Chang, Katia Manova-Todorova, Afsar Barlas, Anne G. Savitt, Brian V. Geisbrecht, Berhane Ghebrehiwet
Publikováno v:
Antibodies, Vol 9, Iss 4, p 51 (2020)
gC1qR is highly expressed in breast cancer and plays a role in cancer cell proliferation. This study explored therapy with gC1qR monoclonal antibody 60.11, directed against the C1q binding domain of gC1qR, in a murine orthotopic xenotransplant model
Externí odkaz:
https://doaj.org/article/b3bfd026ac4f49ce814d26f8b134bf75
Autor:
Fei Ye, Darren R. Feldman, Alisa Valentino, Rachel So, Maria Bromberg, Shah Khan, Samuel A. Funt, Joel Sheinfeld, David B. Solit, Melissa S. Pessin, Ellinor I. Peerschke
Publikováno v:
The Journal of Molecular Diagnostics. 24:867-877
Detection of serum embryonic miRNAs miR-371a-3p and miR-372-3p has been proposed to aid in diagnosis, prognosis, and management of patients with testicular germ cell tumors (GCTs). This study describes the analytical validation and performance of a l
Autor:
Annika, Raschdorf, Annika, Sünderhauf, Kerstin, Skibbe, Berhane, Ghebrehiwet, Ellinor I, Peerschke, Christian, Sina, Stefanie, Derer
Publikováno v:
Frontiers in Oncology
Rapid proliferation of cancer cells is enabled by favoring aerobic glycolysis over mitochondrial oxidative phosphorylation (OXPHOS). P32 (C1QBP/gC1qR) is essential for mitochondrial protein translation and thus indispensable for OXPHOS activity. It i
Autor:
Neerav N, Shukla, Juber A, Patel, Heather, Magnan, Ahmet, Zehir, Daoqi, You, Jiabin, Tang, Fanli, Meng, Aliaksandra, Samoila, Emily K, Slotkin, Srikanth R, Ambati, Alexander J, Chou, Leonard H, Wexler, Paul A, Meyers, Ellinor I, Peerschke, Agnes, Viale, Michael F, Berger, Marc, Ladanyi
Publikováno v:
JCO precision oncology. 2017
Ewing Sarcoma (ES) and Desmoplastic Small Round Cell Tumors (DSRCT) are aggressive sarcomas molecularly characterized byTo investigate the feasibility of identifyingThese results provide a compelling rationale for an integrated approach utilizing bot
Autor:
Dylan Bobrow, Kajal J Kothadia, Hooman Kamel, Costantino Iadecola, Mitchell S Elkind, Ellinor I Peerschke, Gerald A Soff, Lisa M DeAngelis, Babak B Navi
Publikováno v:
Stroke. 46
Introduction: Cancer patients can develop hypercoagulability, leading to stroke. The pathophysiology of cancer-mediated hypercoagulability, however, is poorly understood and biomarkers associated with stroke in cancer patients are uncertain. Methods: