Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Ellie H. Jhun"'
Autor:
Ellie H. Jhun, Nilanjana Sadhu, Xiaoyu Hu, Yingwei Yao, Ying He, Diana J. Wilkie, Robert E. Molokie, Zaijie Jim Wang
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Pain in sickle cell disease (SCD) is severe, variable, and inadequately comprehended. The β2-adrenergic receptor (ADRB2) is critical in mediating neurotransmitter response in the sympathetic nervous system. In this association study, we examined 16
Externí odkaz:
https://doaj.org/article/af26b19a3d9a49c4b126b5e7d0f1b445
Autor:
Ellie H Jhun, Nilanjana Sadhu, Ying He, Yingwei Yao, Diana J Wilkie, Robert E Molokie, Zaijie Jim Wang
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0232721 (2020)
BACKGROUND:Pain in sickle cell disease (SCD) is severe and multifaceted resulting in significant differences in its frequency and intensity among individuals. In this study, we examined the influence of S100B gene single nucleotide polymorphisms (SNP
Externí odkaz:
https://doaj.org/article/8b40c0934656406da5d659a8b607deb5
Autor:
Keesha L Powell-Roach, Yingwei Yao, Ellie H Jhun, Ying He, Marie L Suarez, Miriam O Ezenwa, Robert E Molokie, Zaijie Jim Wang, Diana J Wilkie
Publikováno v:
PLoS ONE, Vol 14, Iss 11, p e0224886 (2019)
PurposeFrequencies of single nucleotide polymorphisms (SNPs) from pain related candidate genes are available for individuals with sickle cell disease (SCD). One of those genes, the arginine vasopressin receptor 1A gene (AVPR1A) and one of its SNPs, r
Externí odkaz:
https://doaj.org/article/e3f501ea495240fbbd1e86ef4aa5b9f9
Autor:
Diana J. Wilkie, Zaijie Jim Wang, Robert E. Molokie, Nilanjana Sadhu, Ellie H. Jhun, Ying He, Andrew K Posen, Yingwei Yao
Publikováno v:
Pharmacogenomics
Aim: Phenylethanolamine N-methyltransferase (PNMT) catalyzes the conversion of sympathetic neurotransmitter norepinephrine to epinephrine. We examined the association of PNMT polymorphisms with acute and chronic pain in sickle cell disease (SCD). Met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5810cf3a991162e7a5afbbb50d37b853
https://doi.org/10.2217/pgs-2019-0096
https://doi.org/10.2217/pgs-2019-0096
Autor:
Mark J. Ratain, Sajid Shahul, Keith Danahey, Peter H. O'Donnell, Jeffrey L. Apfelbaum, Ellie H. Jhun, Randall W. Knoebel, Emily Schierer, Tien M. Truong, Brittany A. Borden, Magdalena Anitescu
Publikováno v:
The pharmacogenomics journal. 21(6)
Variable responses to medications complicates perioperative care. As a potential solution, we evaluated and synthesized pharmacogenomic evidence that may inform anesthesia and pain prescribing to identify clinically actionable drug/gene pairs. Clinic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59b480afa0fe62a53283f101459b65ad
https://pubmed.ncbi.nlm.nih.gov/34376788
https://pubmed.ncbi.nlm.nih.gov/34376788
Autor:
Robert E. Molokie, Zaijie Jim Wang, Yingwei Yao, Nilanjana Sadhu, Diana J. Wilkie, Ellie H. Jhun, Ying He
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 5, p e0232721 (2020)
PLoS ONE, Vol 15, Iss 5, p e0232721 (2020)
Background Pain in sickle cell disease (SCD) is severe and multifaceted resulting in significant differences in its frequency and intensity among individuals. In this study, we examined the influence of S100B gene single nucleotide polymorphisms (SNP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a74511c90a139abbc704eb3c66dd081
http://europepmc.org/articles/PMC7205279
http://europepmc.org/articles/PMC7205279
Autor:
Ellie H. Jhun, Diana J. Wilkie, Robert E. Molokie, Nilanjana Sadhu, Ying He, Zaijie Jim Wang, Yingwei Yao
Publikováno v:
Pharmacogenomics. 19:1003-1011
Aim: Pain in sickle cell disease patients is heterogeneous and genetic polymorphisms may predispose an individual to varied vulnerability to painful events. We studied the association of SNPs in the glucocorticoid receptor gene (NR3C1) with pain in s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51333dce2ae7ed56ca1210930b1403bf
https://doi.org/10.2217/pgs-2018-0064
https://doi.org/10.2217/pgs-2018-0064
Autor:
Marie L. Suarez, Robert E. Molokie, Zaijie Jim Wang, Yingwei Yao, Keesha L. Powell-Roach, Miriam O. Ezenwa, Diana J. Wilkie, Ying He, Ellie H. Jhun
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 11, p e0224886 (2019)
PLoS ONE, Vol 14, Iss 11, p e0224886 (2019)
PurposeFrequencies of single nucleotide polymorphisms (SNPs) from pain related candidate genes are available for individuals with sickle cell disease (SCD). One of those genes, the arginine vasopressin receptor 1A gene (AVPR1A) and one of its SNPs, r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63127f5cf370a11dbcf95d3da80ae0cb
http://europepmc.org/articles/PMC6844466
http://europepmc.org/articles/PMC6844466
Autor:
Peter H. O'Donnell, Keith Danahey, David M. Dickerson, Jeffrey L. Apfelbaum, Ellie H. Jhun, Sajid Shahul, Randall W. Knoebel, Mark J. Ratain
Publikováno v:
Pharmacogenomics
Several high-profile examples of adverse outcomes from medications used in the perioperative setting are well known (e.g., malignant hyperthermia, prolonged apnea, respiratory depression, inadequate analgesia), leading to an increased understanding o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2472d8eeccd89bdb9d6b99ea4c849033
https://pubmed.ncbi.nlm.nih.gov/31411557
https://pubmed.ncbi.nlm.nih.gov/31411557
Autor:
Ying He, Robert E. Molokie, Yingwei Yao, Zaijie Jim Wang, Diana J. Wilkie, Ellie H. Jhun, Xiaoyu Hu
Publikováno v:
Pharmacogenomics. 17:1999-2006
Aim: Pain is prevalent in sickle cell disease (SCD) patients who display great heterogeneity in pain severity and frequency. Hypothesizing that inflammatory factors are involved in the pathogenesis of SCD pain, we focused on the IL1A C/T polymorphism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83164ac02e55eeaf527277f5901a747c
https://doi.org/10.2217/pgs-2016-0085
https://doi.org/10.2217/pgs-2016-0085