Serum-Induced Differentiation of Glioblastoma Neurospheres Leads to Enhanced Migration/Invasion Capacity That Is Associated with Increased MMP9.

Autor: Justin V Joseph, Ingrid A M van Roosmalen, Ellen Busschers, Tushar Tomar, Siobhan Conroy, Ellie Eggens-Meijer, Natalia Peñaranda Fajardo, Milind M Pore, Veerakumar Balasubramanyian, Michiel Wagemakers, Sjef Copray, Wilfred F A den Dunnen, Frank A E Kruyt

Publikováno v: PLoS ONE, Vol 10, Iss 12, p e0145393 (2015)

Glioblastoma (GBM) is a highly infiltrative brain tumor in which cells with properties of stem cells, called glioblastoma stem cells (GSCs), have been identified. In general, the dominant view is that GSCs are responsible for the initiation, progress

Externí odkaz: https://doaj.org/article/21fcd2628e2b4d62b7ed4ed1c898e049

No disease in the brain of a 115-year-old woman

Autor: Wiebo Brouwer, Ellie Eggens-Meijer, Klaas van Linschoten, Jeanine Kamphuis, Gert Holstege, Eveline Bijlard, Wilfred F. A. den Dunnen

Publikováno v: Neurobiology of Aging, 29(8), 1127-1132. ELSEVIER SCIENCE INC

Are there limits to the duration of high quality of life? Are there limits to healthy life for a human brain? We have had the opportunity to evaluate the performance of a 112-113-year-old woman and perform full pathological examination of her body im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b39559e2818559f013ad74a3f23f79f5
https://research.rug.nl/en/publications/0ce2ec43-3d39-422c-be6d-2d41ca40e7ac

Hypoxia enhances migration and invasion in glioblastoma by promoting a mesenchymal shift mediated by the HIF1α-ZEB1 axis

Autor: Frank A.E. Kruyt, Michiel Wagemakers, Wilfred F. A. den Dunnen, Kirill Pavlov, Veerakumar Balasubramaniyan, Tushar Tomar, Justin V. Joseph, Pallavi Sontakke, Siobhan Conroy, Ellie Eggens-Meijer

Publikováno v: Cancer letters, 359(1), 107-116. ELSEVIER IRELAND LTD

Glioblastoma (GBM) is the most common brain tumor in adults and the mesenchymal GBM subtype was reported to be the most malignant, presenting severe hypoxia and necrosis. Here, we investigated the possible role of a hypoxic microenvironment for induc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beba20b40d3159cbb54f56fd0ee72a93
https://research.rug.nl/en/publications/7c9d88d5-6c88-4877-94b2-e44d3bb1efd3

TGF-β is an inducer of ZEB1-dependent mesenchymal transdifferentiation in glioblastoma that is associated with tumor invasion

Autor: Annemiek M E Walenkamp, Frank A.E. Kruyt, V Balasubramanyian, Sjef Copray, K Bhat, Siobhan Conroy, Tushar Tomar, Erik Boddeke, Justin V. Joseph, W. F. A. den Dunnen, Michiel Wagemakers, Ellie Eggens-Meijer

Publikováno v: Cell death & disease, 5:1443. Nature Publishing Group
Cell Death & Disease

Different molecular subtypes of glioblastoma (GBM) have been recently identified, of which the mesenchymal subtype is associated with worst prognoses. Here, we report that transforming growth factor-β (TGF-β) is able to induce a mesenchymal phenoty

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fdd003aa4c182e78f27709e882b7559
https://doi.org/10.1038/cddis.2014.395

Involvement of the insular cortex in regulating glucocorticoid effects on memory consolidation of inhibitory avoidance training

Autor: Romy Wichmann, Tifany Desprez, Raquel Vecchio Fornari, Benno Roozendaal, Erika Atucha, Ellie Eggens-Meijer

Publikováno v: Frontiers in Behavioral Neuroscience, 6:10. Frontiers Media S.A.
Frontiers in Behavioral Neuroscience, Vol 6 (2012)
Frontiers in Behavioral Neuroscience, 6
Frontiers in Behavioral Neuroscience

Contains fulltext : 108435.pdf (Publisher’s version ) (Open Access) Glucocorticoids are known to enhance the consolidation of memory of emotionally arousing experiences by acting upon a network of interconnected brain regions. Although animal studi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47482edfab7e9d8a94f226974e0302eb
https://research.rug.nl/en/publications/fb70c0f3-1c31-4c25-9096-100825a5ddc8