Výsledky vyhledávání - "Elli Kruithof"

Spondylarthritis in the absence of B lymphocytes

Autor: Maxime Breban, Elli Kruithof, Paul P. Tak, Dominique Baeten

Publikováno v: Arthritis and rheumatism, 58(3), 730-733. John Wiley and Sons Inc.

The highly effective treatment of rheumatoid arthritis by B cell depletion and the presence of B cells in the peripheral and axial lesions of patients with spondylarthritis (SpA) raise the question as to whether B lymphocytes could also be an appropr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40235a0eb6b0fb9afa948939c8ca4149
https://doi.org/10.1002/art.23266

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Distinct synovial immunopathologic characteristics of juvenile-onset spondylarthritis and other forms of juvenile idiopathic arthritis

Autor: Rik Joos, Eric Veys, Bernard Vandooren, Paul P. Tak, Annemieke M. H. Boots, Juan D. Cañete, Veronique Van den Bossche, Elli Kruithof, Dominique Baeten, Leen De Rycke

Publikováno v: Arthritis and rheumatism, 54(8), 2594-2604. John Wiley and Sons Inc.

Objective To characterize the synovial immunopathologic features of juvenile-onset spondylarthritis (SpA) in relation to adult SpA and other forms of juvenile idiopathic arthritis (JIA). Methods Synovial biopsy samples were obtained from 10 patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f986951be5daa32cb776e540d4be8020
https://doi.org/10.1002/art.22024

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Identification of synovial biomarkers of response to experimental treatment in early-phase clinical trials in spondylarthritis

Autor: Dominique Baeten, Eric Veys, Elli Kruithof, Oliver FitzGerald, Paul P. Tak, Iain B. McInnes, Barry Bresnihan, Leen De Rycke, Bernard Vandooren, Filip De Keyser

Publikováno v: Arthritis and rheumatism, 54(6), 1795-1804. John Wiley and Sons Inc.

Objective To identify biomarkers for effective treatment in early-phase clinical trials of spondylarthritis (SpA), by analyzing which synovial features can be reliably identified in patients with SpA. Methods Synovial biopsies were performed at weeks

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7d0211f7abad14abcacbdfe7ca05024
https://doi.org/10.1002/art.21914

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Infliximab, but not etanercept, induces IgM anti-double-stranded DNA autoantibodies as main antinuclear reactivity: biologic and clinical implications in autoimmune arthritis

Autor: Leen De Rycke, Filip Van den Bosch, Dominique Baeten, Elli Kruithof, Filip De Keyser, Eric Veys

Publikováno v: Arthritis and rheumatism, 52(7), 2192-2201. John Wiley and Sons Inc.

Objective To analyze the clinical and biologic correlates of autoantibody induction during longer-term tumor necrosis factor α (TNFα) blockade with either the monoclonal antibody infliximab or the soluble receptor etanercept. Methods Thirty-four pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4984e0e45dcf7f6c1cbd71f444572e8
https://doi.org/10.1002/art.21190

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Synovial intracellular citrullinated proteins colocalizing with peptidyl arginine deiminase as pathophysiologically relevant antigenic determinants of rheumatoid arthritis-specific humoral autoimmunity

Autor: Tineke Cantaert, Elli Kruithof, Leen De Rycke, Filip De Keyser, Anthony P. Nicholas, Bart Vandekerckhove, Dominique Baeten, Eric Veys, Joshua D. Echols

Publikováno v: Arthritis and rheumatism, 52(8), 2323-2330. John Wiley and Sons Inc.

Objective To address the ongoing debate concerning the specificity of synovial citrullinated proteins for rheumatoid arthritis (RA) and to analyze their pathophysiologic relevance to the induction or perpetuation of the RA-specific anti–citrullinat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f82918d149d026333724c9d452254e7
https://doi.org/10.1002/art.21220

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Structure-Modifying Capacity of Anti-Tumour Necrosis Factor-?? Therapy in Ankylosing Spondylitis

Autor: Elli Kruithof, Filip De Keyser, Herman Mielants, Filip Van den Bosch, Eric Veys, Gust Verbruggen, Dominique Baeten

Publikováno v: Drugs. 64:2793-2811

Spondylarthropathies (SpA) present mainly with spondylitis, pauciarticular peripheral arthritis and enthesopathy. Ankylosing spondylitis (AS) is the prototype disease in this concept. Other entities include reactive arthritis, arthritis in patients w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8b922809f975434beaac68ba01395e9
https://doi.org/10.2165/00003495-200464240-00005

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Involvement of matrix metalloproteinases and their inhibitors in peripheral synovitis and down-regulation by tumor necrosis factor ? blockade in spondylarthropathy

Autor: Bernard Vandooren, Filip Van den Bosch, Filip De Keyser, Dominique Baeten, Eric Veys, Elli Kruithof, Markus Rihl, Jieruo Gu, David T. Y. Yu, Leen De Rycke

Publikováno v: Arthritis and rheumatism, 50(9), 2942-2953. John Wiley and Sons Inc.

Objective To investigate the role of matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) in spondylarthropathy (SpA) synovitis. Methods Paired samples of synovial biopsy tissue as well as serum and synovial flu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f1902f5e876943c9d3f32b5c3721ba9
https://doi.org/10.1002/art.20477

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Systematic safety follow up in a cohort of 107 patients with spondyloarthropathy treated with infliximab: a new perspective on the role of host defence in the pathogenesis of the disease?

Autor: Herman Mielants, E M Veys, N Van den Bossche, A Herssens, Dominique Baeten, F De Keyser, Elli Kruithof, F. Van den Bosch

Publikováno v: Annals of the rheumatic diseases, 62(9), 829-834. BMJ Publishing Group

Background: Recent studies with infliximab indicate the therapeutic potential of tumour necrosis factor α blockade in spondyloarthropathy (SpA). Because defective host defence is implicated in the pathogenesis of SpA, the potential side effects of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45b80695a6d12060c1891b4c3e641ab9
https://doi.org/10.1136/ard.62.9.829

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Antinuclear antibodies following infliximab treatment in patients with rheumatoid arthritis or spondylarthropathy

Autor: Leen De Rycke, Eric Veys, Filip Van den Bosch, Elli Kruithof, Nancy Van Damme, Ilse Hoffman, Filip De Keyser, Nancy Van den Bossche

Publikováno v: Arthritis & Rheumatism. 48:1015-1023

Objective To investigate the effect of infliximab treatment on antinuclear antibodies (ANAs), anti–double-stranded DNA (anti-dsDNA), antinucleosome, antihistone, and anti–extractable nuclear antigen (anti-ENA) antibodies in rheumatoid arthritis (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ec83009c23bd54d30d13d9587bf875f
https://doi.org/10.1002/art.10876

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Infliximab in patients who have spondyloarthropathy: clinical efficacy, safety, and biological immunomodulation

Autor: Herman Mielants, Filip De Keyser, Eric Veys, Elli Kruithof, Filip Van den Bosch, Dominique Baeten

Publikováno v: Rheumatic diseases clinics of North America, 29(3), 463-479. W.B. Saunders Ltd

A major breakthrough has been achieved in the treatment of patients who have AS and other types of SpA. The identification of the expression and role of TNF-alpha in patients who have these diseases and the recognition of their relation with gut infl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17264d6d1a2de54841987b83260bbdc7
https://doi.org/10.1016/s0889-857x(03)00052-8

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