Effect of Vitamin D3 on the Postprandial Lipid Profile in Obese Patients: A Non-Targeted Lipidomics Study

Autor: Salvador Fernández-Arroyo, Anna Hernández-Aguilera, Marijke A. de Vries, Benjamin Burggraaf, Ellen van der Zwan, Nadine Pouw, Jorge Joven, Manuel Castro Cabezas

Publikováno v: Nutrients, Vol 11, Iss 5, p 1194 (2019)

Postprandial lipemia can lead to an accumulation of atherogenic lipoproteins in the circulation associated with systemic low-grade inflammation and an increased risk of cardiovascular disease. Lifestyle and pharmacological treatments are usually pres

Externí odkaz: https://doaj.org/article/ad9271f6caf043c186a04b5f8b239361

A placebo-controlled proof-of-concept study of alirocumab on postprandial lipids and vascular elasticity in insulin-treated patients with type 2 diabetes mellitus

Autor: Jeannine Huisbrink, Manuel Castro Cabezas, Monique T. Mulder, Nadine Pouw, Gert-Jan M. van de Geijn, Benjamin Burggraaf, Leonie C. van Vark-van der Zee, Patrick C.N. Rensen, Ellen van der Zwan, Wouter W. de Herder, Salvador Fernandez Arroyo, Erwin Birnie

Publikováno v: Diabetes obesity & metabolism, 22(5), 807-816. Wiley
Diabetes, Obesity and Metabolism, 22(5), 807-816. Wiley-Blackwell Publishing Ltd
Diabetes, Obesity and Metabolism, 22(5), 807-816. WILEY

AIM: Type 2 diabetes mellitus (T2DM) is associated with an increased risk of cardiovascular disease (CVD) linked to atherogenic dyslipidaemia and postprandial hyperlipidaemia. Alirocumab, a proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cda152640ae291fef69e6bdcb34f9c1e
https://hdl.handle.net/11370/198197d2-8ddc-40ef-b282-e717e759b5f3

Rapid Detection of the Three Celiac Disease Risk Genotypes HLA-DQ2.2, HLA-DQ2.5, and HLA-DQ8 by Multiplex Ligation-Dependent Probe Amplification

Autor: Ellen van der Zwan, Ellen de Baar, Raymon Vijzelaar, Ingrid M.W. van Hoogstraten, Wouter Kortlandt, Adriaan J. van Gammeren, Rizkat Yilmaz, Lianne Schrauwen, Alice Verheul

Publikováno v: Genetic Testing and Molecular Biomarkers, 20(3), 158-161. Mary Ann Liebert Inc.
Vijzelaar, R, van der Zwan, E, van Gammeren, A, Yilmaz, R, Verheul, A, van Hoogstraten, I, de Baar, E, Schrauwen, L & Kortlandt, W 2016, ' Rapid Detection of the Three Celiac Disease Risk Genotypes HLA-DQ2.2, HLA-DQ2.5, and HLA-DQ8 by Multiplex Ligation-Dependent Probe Amplification ', Genetic Testing and Molecular Biomarkers, vol. 20, no. 3, pp. 158-161 . https://doi.org/10.1089/gtmb.2015.0233

Background: Genotyping of HLA-DQ2.2, HLA-DQ2.5, and HLA-DQ8 is important in celiac disease (CD). The absence of these three genotypes has a strong negative predictive value. Methods: We designed multiplex ligation-dependent probe amplification (MLPA)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af864172d7ec5b3d8bac577cfb1ee250
https://doi.org/10.1089/gtmb.2015.0233

Leucocyte-bound apolipoprotein B in the circulation is inversely associated with the presence of clinical and subclinical atherosclerosis

Autor: Noelle van der Meulen, Marijke A. de Vries, Ellen van der Zwan, Manuel Castro Cabezas, Jan Willem Cohen Tervaert, Erwin Birnie, Anho H. Liem, Gert-Jan M. van de Geijn, Lenneke Prinzen, B. Klop, Wouter W. de Herder

Publikováno v: European Journal of Clinical Investigation, 46(8), 690-697. Wiley-Blackwell Publishing Ltd

Background Atherosclerosis is a pro-inflammatory condition, in which leucocyte activation plays an important role. The interaction between circulating leucocytes and apolipoprotein (apo) B-containing lipoproteins results in pro-inflammatory changes o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7e11727f2a744ec2c682d419c6a17ad
https://pure.eur.nl/en/publications/4c483aaf-af01-4a86-8206-33feece74aeb