Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Ellen Y.T. Chien"'
Autor:
Michael J. Chalmers, Graham M. West, Vsevolod Katritch, Ellen Y.T. Chien, Raymond C. Stevens, Jovylyn Gatchalian, Patrick R. Griffin
Publikováno v:
Structure. 19(10):1424-1432
Mechanism of G-protein coupled receptor (GPCR) activation and their modulation by functionally distinct ligands remains elusive. Using the technique of amide hydrogen/deuterium exchange coupled with mass spectrometry we examined the ligand-induced ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a06bd25cb4ee8cdee8403c3f62c5b6a
Autor:
Raymond C. Stevens, Vsevolod Katritch, Jonathan A. Javitch, Lei Shi, Wei Liu, Ellen Y.T. Chien, Vadim Cherezov, Qiang Zhao, Gye Won Han, Michael A. Hanson, Amy Hauck Newman
Publikováno v:
Science. 330:1091-1095
Tweaking Dopamine Reception Dopamine modulates many cognitive and emotional functions of the human brain by activating G protein–coupled receptors. Antipsychotic drugs that block two of the receptor subtypes are used to treat schizophrenia but have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92d16906b30440f6ed035e83c35ee445
https://doi.org/10.1126/science.1197410
https://doi.org/10.1126/science.1197410
Autor:
Clifford D. Mol, Gustavo Fenalti, Peter A. Wells, Ellen Y.T. Chien, Peter Kuhn, Tracy M. Handel, Raymond C. Stevens, Beili Wu, Wei Liu, Vsevolod Katritch, Ruben Abagyan, F. Christopher Bi, Damon J. Hamel, Vadim Cherezov, Alexei Brooun
Publikováno v:
Science. 330:1066-1071
Regulating Migration The migration of cells around the body is an important factor in cancer development and the establishment of infection. Movement is induced by small proteins called chemokines, and so for a specific function, migration is control
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1acfa47838ce11f51a79f25bf39759b6
https://doi.org/10.1126/science.1194396
https://doi.org/10.1126/science.1194396
Autor:
Michael A. Hanson, Alexander I. Alexandrov, Raymond C. Stevens, Ellen Y.T. Chien, Mauro Mileni
Publikováno v:
Structure. 16(3):351-359
SummarySystematic efforts to understand membrane protein stability under a variety of different solution conditions are not widely available for membrane proteins, mainly due to technical problems stemming from the presence of detergents necessary to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d21671fe3bb8fec7174653502afefb5
Autor:
Ellen Y.T. Chien, Christopher B. Roth, Mark Yeager, Raymond C. Stevens, Michael A. Hanson, Yuanzi Hua, Kin Moy, Mark T. Griffith, Kent A. Baker, Jeffrey Velasquez, Sam Ellis, Alexei Brooun, Leila K. Davis, Alexander I. Alexandrov, Peter Kuhn, Veli-Pekka Jaakola, Barbie K. Ganser-Pornillos
Publikováno v:
Protein Expression and Purification. 56:85-92
Production of structure-grade mammalian membrane proteins in substantial quantities has been hindered by a lack of methods for effectively profiling multiple constructs expression in higher eukaryotic systems such as insect or mammalian cells. To add
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64e4f5a9148d27d10f3b92b2be9493da
https://doi.org/10.1016/j.pep.2007.06.003
https://doi.org/10.1016/j.pep.2007.06.003
Autor:
Jovylyn Gatchalian, Bruce D. Pascal, Patrick R. Griffin, Xi Zhang, Raymond C. Stevens, Ellen Y.T. Chien, Michael J. Chalmers
Publikováno v:
Analytical chemistry. 82(3)
To examine the molecular details of ligand activation of G-protein coupled receptors (GPCRs), emphasis has been placed on structure determination of these receptors with stabilizing ligands. Here we present the methodology for receptor dynamics chara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40d273a583e5119d8f4b082bcccbed0d
https://pubmed.ncbi.nlm.nih.gov/20058880
https://pubmed.ncbi.nlm.nih.gov/20058880
Autor:
Mark T. Griffith, Vadim Cherezov, Ellen Y.T. Chien, Raymond C. Stevens, Michael A. Hanson, J. Robert Lane, Adriaan P. IJzerman, Veli-Pekka Jaakola
The adenosine class of heterotrimeric guanine nucleotide–binding protein (G protein)–coupled receptors (GPCRs) mediates the important role of extracellular adenosine in many physiological processes and is antagonized by caffeine. We have determin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37056172fab50ee5f8e4b8d42b3470b1
https://europepmc.org/articles/PMC2586971/
https://europepmc.org/articles/PMC2586971/
Autor:
Gisbert Weckbecker, Ellen Y.T. Chien, Paul Ramage, Markus Streiff, Jill E. Chrencik, Alexei Brooun, Scott A. Foster, Peter Kuhn, Hans Widmer, Anand Kolatkar
Publikováno v:
Protein expression and purification. 53(1)
The signal transduction pathway involving the Vav1 guanine nucleotide exchange factor (GEF) and the Rac1 GTPase plays several key roles in the immune response mediated by the T cell receptor. Vav1 is also a unique member of the GEF family in that it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57508bb83443ecd0cdba096660cf9b4f
https://pubmed.ncbi.nlm.nih.gov/17275330
https://pubmed.ncbi.nlm.nih.gov/17275330
Autor:
Ciarán N. Cronin, Hua Zou, Clifford D. Mol, Vandana Sridhar, Daniel B. Kassel, Duncan E. McRee, Ellen Y.T. Chien, Kheng B. Lim, Jacek Nowakowski, Bi-Ching Sang
Publikováno v:
The Journal of biological chemistry. 278(34)
The c-Kit proto-oncogene is a receptor protein-tyrosine kinase associated with several highly malignant human cancers. Upon binding its ligand, stem cell factor (SCF), c-Kit forms an active dimer that autophosphorylates itself and activates a signali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb2a96b98740001cc5d45af142d87b6d
https://pubmed.ncbi.nlm.nih.gov/12824176
https://pubmed.ncbi.nlm.nih.gov/12824176