Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Ellen Wiedtke"'
Autor:
Xiaoyan Wang, Patrick Julian Klann, Ellen Wiedtke, Yumi Sano, Nico Fischer, Lisa Schiller, Anna Elfert, Anne-Katrin Güttsches, Ute Weyen, Dirk Grimm, Matthias Vorgerd, Wibke Bayer
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
High levels of pre-existing antibodies are a major challenge for the application of viral vectors since they can severely limit their efficacy. To identify promising candidates among adeno-associated virus (AAV) based vectors for future gene therapie
Externí odkaz:
https://doaj.org/article/678bdd0209ea4d16bd2e41790c7c76a6
Autor:
Lea Jessica Flitsch, Kathleen Börner, Christian Stüllein, Simon Ziegler, Vera Sonntag-Buck, Ellen Wiedtke, Vesselina Semkova, Si Wah Christina Au Yeung, Julia Schlee, Mohamad Hajo, Mona Mathews, Beatrice Stefanie Ludwig, Susanne Kossatz, Horst Kessler, Dirk Grimm, Oliver Brüstle
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Human brain cells generated by in vitro cell programming provide exciting prospects for disease modeling, drug discovery and cell therapy. These applications frequently require efficient and clinically compliant tools for genetic modificatio
Externí odkaz:
https://doaj.org/article/4875817cf7bc4d6497c93a0dff7c11d4
Autor:
Elena Senís, Lluc Mosteiro, Stefan Wilkening, Ellen Wiedtke, Ali Nowrouzi, Saira Afzal, Raffaele Fronza, Henrik Landerer, Maria Abad, Dominik Niopek, Manfred Schmidt, Manuel Serrano, Dirk Grimm
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
In vivo reprogramming of somatic cells is hampered by the need for vectors to express the OKSM factors in selected organs. Here the authors report new AAV-based vectors capable of in vivo reprogramming at low doses.
Externí odkaz:
https://doaj.org/article/097051282c3e433e8f3bfa8162e92d23
Autor:
Dirk Grimm, Ellen Wiedtke, Chiara Krämer, Emma Gerstmann, Jixin Liu, Felix Bubeck, Margarita Zayas, Joanna Szumska, Jonas Becker, Olena Maiakovska, Kleopatra Rapti
Publikováno v:
Journal of Visualized Experiments.
Gene delivery vectors derived from Adeno-associated virus (AAV) are one of the most promising tools for the treatment of genetic diseases, evidenced by encouraging clinical data and the approval of several AAV gene therapies. Two major reasons for th
Autor:
Eike Kienle, Kathleen Börner, Dirk Grimm, Alexander Rau, Jürgen Beneke, Adrian Westhaus, Lin-Ya Huang, Julia Fakhiri, Jonas Weinmann, Carolin Schmelas, Laura Zimmermann, Hans-Georg Kräusslich, Dominik Miltner, Christian Stüllein, Ellen Wiedtke, Martin Müller, Holger Erfle, Nina Beil, Anna Sacher, Mavis Agbandje-McKenna, Philipp Bayer
Publikováno v:
Mol Ther
Display of short peptides on the surface of adeno-associated viruses (AAVs) is a powerful technology for the generation of gene therapy vectors with altered cell specificities and/or transduction efficiencies. Following its extensive prior use in the
Autor:
Jonas Becker, Megan Lynn Stanifer, Sarah Rebecca Leist, Bettina Stolp, Olena Maiakovska, Ande West, Ellen Wiedtke, Kathleen Börner, Ali Ghanem, Ina Ambiel, Longping Victor Tse, Oliver Till Fackler, Ralph Steven Baric, Steeve Boulant, Dirk Grimm
Publikováno v:
Molecular Therapy
Despite rapid development and deployment of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), clinically relevant modalities to curb the pandemic by directly attacking the virus on a genetic level remain highly desirable
Autor:
Lea Jessica, Flitsch, Kathleen, Börner, Christian, Stüllein, Simon, Ziegler, Vera, Sonntag-Buck, Ellen, Wiedtke, Vesselina, Semkova, Si Wah Christina, Au Yeung, Julia, Schlee, Mohamad, Hajo, Mona, Mathews, Beatrice Stefanie, Ludwig, Susanne, Kossatz, Horst, Kessler, Dirk, Grimm, Oliver, Brüstle
Publikováno v:
Scientific reports. 12(1)
Human brain cells generated by in vitro cell programming provide exciting prospects for disease modeling, drug discovery and cell therapy. These applications frequently require efficient and clinically compliant tools for genetic modification of the
Autor:
Dirk Grimm, Florian Hetsch, Janina Kupke, Anna D'Errico, Ralf H. Adams, Andromachi Karakatsani, Hellmut G. Augustin, Hyun-Woo Jeong, Géza Schermann, Michaela K Back, Heike Adler, Michele De Palma, Ellen Wiedtke, Robert Luck, Jakob von Engelhardt, Amparo Acker-Palmer, Carmen Ruiz de Almodovar, Nathalie Tisch, Bhavin Shah
Publikováno v:
Cell Reports
Neuro-vascular communication is essential to synchronize central nervous system development. Here, we identify angiopoietin/Tie2 as a neuro-vascular signaling axis involved in regulating dendritic morphogenesis of Purkinje cells (PCs). We show that i
Autor:
Dominik Niopek, Elena Senís, María Abad, Dirk Grimm, Stefan Wilkening, Saira Afzal, Henrik Landerer, Lluc Mosteiro, Ellen Wiedtke, Ali Nowrouzi, Raffaele Fronza, Manuel Serrano, Manfred Schmidt
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Repisalud
Instituto de Salud Carlos III (ISCIII)
Nature Communications
Repisalud
Instituto de Salud Carlos III (ISCIII)
Nature Communications
In vivo reprogramming of somatic cells into induced pluripotent stem cells (iPSC) holds vast potential for basic research and regenerative medicine. However, it remains hampered by a need for vectors to express reprogramming factors (Oct-3/4, Klf4, S
Autor:
Pierre Roques, Roger Le Grand, Isabelle Chemin, Florian W. R. Vondran, Bingqian Qu, Ellen Wiedtke, Stephan Urban, Dirk Grimm, Florian A. Lempp
Publikováno v:
Hepatology. 66:703-716
Infections with the human hepatitis B virus (HBV) and hepatitis D virus (HDV) depend on species-specific host factors like the receptor human sodium taurocholate cotransporting polypeptide (hNTCP). Complementation of mouse hepatocytes with hNTCP conf