Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Ellen Van Gulck"'
Autor:
Marion Pardons, Basiel Cole, Laurens Lambrechts, Willem van Snippenberg, Sofie Rutsaert, Ytse Noppe, Nele De Langhe, Annemieke Dhondt, Jerel Vega, Filmon Eyassu, Erik Nijs, Ellen Van Gulck, Daniel Boden, Linos Vandekerckhove
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract The development of latency reversing agents that potently reactivate HIV without inducing global T cell activation would benefit the field of HIV reservoir research and could pave the way to a functional cure. Here, we explore the reactivati
Externí odkaz:
https://doaj.org/article/3f371f7550f64091855de84f1077f564
Autor:
Dorien De Pooter, Ben De Clerck, Koen Dockx, Domenica De Santis, Sarah Sauviller, Pascale Dehertogh, Matthias Beyens, Isabelle Bergiers, Isabel Nájera, Ellen Van Gulck, Nádia Conceição-Neto, Wim Pierson
Publikováno v:
PLoS ONE, Vol 19, Iss 8, p e0304063 (2024)
Research on liver-related conditions requires a robust and efficient method to purify viable hepatocytes, lymphocytes and all other liver resident cells, such as Kupffer or liver sinusoidal endothelial cells. Here we describe a novel purification met
Externí odkaz:
https://doaj.org/article/b80be72f13f54bdfaa0add119102f4db
Autor:
Dorien De Pooter, Wim Pierson, Soheil Pourshahian, Koen Dockx, Ben De Clerck, Isabel Najera, Heather Davis, Ellen Van Gulck, Daniel Boden
Publikováno v:
Vaccines, Vol 12, Iss 3, p 237 (2024)
Chronic infection with hepatitis B virus (HBV) develops in millions of patients per year, despite the availability of effective prophylactic vaccines. Patients who resolve acute HBV infection develop HBV-specific polyfunctional T cells accompanied by
Externí odkaz:
https://doaj.org/article/df00572e29d84e5eb22d4366e69e6a16
Autor:
Ellen Van Gulck, Nádia Conceição-Neto, Liese Aerts, Wim Pierson, Lore Verschueren, Mara Vleeschouwer, Vinod Krishna, Isabel Nájera, Frederik Pauwels
Publikováno v:
Viruses, Vol 16, Iss 3, p 347 (2024)
Background and Aims: Treatment with siRNAs that target HBV has demonstrated robust declines in HBV antigens. This effect is also observed in the AAV-HBV mouse model, which was used to investigate if two cycles of GalNAc-HBV-siRNA treatment could indu
Externí odkaz:
https://doaj.org/article/8c9c0814de054b738973385f440ef96e
Autor:
Nádia Conceição-Neto, Wim Pierson, Maurizio Vacca, Matthias Beyens, Ben De Clerck, Liese Aerts, Birgit Voeten, Dorien De Pooter, Lore Verschueren, Koen Dockx, Mathias Vandenberk, Ewoud De Troyer, Kato Verwilt, Carl Van Hove, Mieke Verslegers, Leslie Bosseler, Marjolein Crabbe, Vinod Krishna, Isabel Nájera, Ellen Van Gulck
Publikováno v:
Vaccines, Vol 11, Iss 12, p 1825 (2023)
Background: Suppression of HBV DNA, inhibition of HBV surface (HBsAg) production and therapeutic vaccination to reverse HBV-specific T-cell exhaustion in chronic HBV patients are likely required to achieve a functional cure. In the AAV-HBV mouse mode
Externí odkaz:
https://doaj.org/article/02d6e9e3b591445ea06f0b781cc5a5c2
Autor:
Dorien De Pooter, Ellen Van Gulck, Antony Chen, Claire F. Evans, Jean-Marc Neefs, Helen Horton, Daniel Boden
Publikováno v:
Vaccines, Vol 9, Iss 9, p 969 (2021)
Despite the availability of an effective prophylactic vaccine for more than 30 years, nearly 300 million people worldwide are chronically infected with the hepatitis B virus (HBV), leading to 1 death every 30 s mainly from viral hepatitis-related cir
Externí odkaz:
https://doaj.org/article/47a9fd0208164534a56fcca1e29d82a0
Autor:
Katie Amssoms, Philip A Born, Max Beugeling, Ben De Clerck, Ellen Van Gulck, Wouter L J Hinrichs, Henderik W Frijlink, Niels Grasmeijer, Guenter Kraus, Roger Sutmuller, Kenny Simmen, Lieven Baert
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0202961 (2018)
A single-injection vaccine formulation that provides for both a prime and a boost immunization would have various advantages over a multiple-injection regime. For such a vaccine formulation, it is essential that the booster dose is released after a c
Externí odkaz:
https://doaj.org/article/39d9cf7d09974343b19898981fbcf509
Autor:
Max Beugeling, Katie Amssoms, Freek Cox, Ben De Clerck, Ellen Van Gulck, Jeroen A. Verwoerd, Guenter Kraus, Dirk Roymans, Lieven Baert, Henderik W. Frijlink, Wouter L. J. Hinrichs
Publikováno v:
Pharmaceutics, Vol 11, Iss 10, p 510 (2019)
Currently, there is an increasing interest to apply pre-fusion (pre-F) protein of respiratory syncytial virus (RSV) as antigen for the development of a subunit vaccine. A pre-F-containing powder would increase the flexibility regarding the route of a
Externí odkaz:
https://doaj.org/article/1fab9f6aa5144ad296de6c6ca8e08c85
Autor:
Maneesh Singh, Pratibha Singh, Gilles Gaudray, Lucia Musumeci, Caroline Thielen, Dolores Vaira, Claire Vandergeeten, Laurence Delacroix, Ellen Van Gulck, Guido Vanham, Laurence de Leval, Souad Rahmouni, Michel Moutschen
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38491 (2012)
Cord blood hematopoietic progenitor cells (CB-HPCs) transplanted immunodeficient NOD/LtsZ-scidIL2Rγ(null) (NSG) and NOD/SCID/IL2Rγ(null) (NOG) mice need efficient human cell engraftment for long-term HIV-1 replication studies. Total body irradiatio
Externí odkaz:
https://doaj.org/article/06049da946cf429fa48b6cef5eb1fa38
Autor:
Ellen Van Gulck, Nathalie Cools, Derek Atkinson, Lotte Bracke, Katleen Vereecken, Marc Vekemans, Viggo F. I. Van Tendeloo, Zwi N. Berneman, Guido Vanham
Publikováno v:
Clinical and Developmental Immunology, Vol 2012 (2012)
A variety of immune-based therapies has been developed in order to boost or induce protective CD8+ T cell responses in order to control HIV replication. Since dendritic cells (DCs) are professional antigen-presenting cells (APCs) with the unique capa
Externí odkaz:
https://doaj.org/article/4f4ef63f4f194d7eb9a4193900256c44