Zobrazeno 1 - 10
of 192
pro vyhledávání: '"Ellen V. Rothenberg"'
Publikováno v:
npj Systems Biology and Applications, Vol 10, Iss 1, Pp 1-13 (2024)
Abstract T-cell development provides an excellent model system for studying lineage commitment from a multipotent progenitor. The intrathymic development process has been thoroughly studied. The molecular circuitry controlling it has been dissected a
Externí odkaz:
https://doaj.org/article/86abcb0a5959447c931f752b7e8e89eb
Autor:
Kazuaki Matsumoto, Kazuki Okuyama, Tom Sidwell, Motoi Yamashita, Takaho Endo, Naoko Satoh-Takayama, Hiroshi Ohno, Tomohiro Morio, Ellen V. Rothenberg, Ichiro Taniuchi
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BCL11B is a transcription factor with six C2H2-type zinc-finger domains. Studies in mice have shown that Bcl11b plays essential roles in T cell development. Several germline heterozygous BCL11B variants have been identified in human patients with inb
Externí odkaz:
https://doaj.org/article/83c8db04a2b14d88adbf03ead9999ff0
Autor:
Boyoung Shin, Ellen V. Rothenberg
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
T cells develop from multipotent progenitors by a gradual process dependent on intrathymic Notch signaling and coupled with extensive proliferation. The stages leading them to T-cell lineage commitment are well characterized by single-cell and bulk R
Externí odkaz:
https://doaj.org/article/79498e10f7ab4f27bb1048f85bbb316e
Autor:
Tom Sidwell, Ellen V. Rothenberg
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The transcription factor Bcl11b is critically required to support the development of diverse cell types, including T lymphocytes, type 2 innate lymphoid cells, neurons, craniofacial mesenchyme and keratinocytes. Although in T cell development its ons
Externí odkaz:
https://doaj.org/article/091a75f966e94bf0a0a9df0ae0ad363f
Autor:
Victor Olariu, Mary A. Yui, Pawel Krupinski, Wen Zhou, Julia Deichmann, Emil Andersson, Ellen V. Rothenberg, Carsten Peterson
Publikováno v:
Cell Reports, Vol 34, Iss 2, Pp 108622- (2021)
Summary: Intrathymic development of committed progenitor (pro)-T cells from multipotent hematopoietic precursors offers an opportunity to dissect the molecular circuitry establishing cell identity in response to environmental signals. This transition
Externí odkaz:
https://doaj.org/article/723410fbb33d48149805c742a6544291
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
PU.1 is an ETS-family transcription factor that plays a broad range of roles in hematopoiesis. A direct regulator of myeloid, dendritic-cell, and B cell functional programs, and a well-known antagonist of terminal erythroid cell differentiation, it i
Externí odkaz:
https://doaj.org/article/04251b20a5ed4d7bb8cd693505b59513
Autor:
Inge Van de Walle, Anne-Catherine Dolens, Kaat Durinck, Katrien De Mulder, Wouter Van Loocke, Sagar Damle, Els Waegemans, Jelle De Medts, Imke Velghe, Magda De Smedt, Bart Vandekerckhove, Tessa Kerre, Jean Plum, Georges Leclercq, Ellen V. Rothenberg, Pieter Van Vlierberghe, Frank Speleman, Tom Taghon
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Strong Notch signalling promotes initial T cell lineage specification of lymphoid progenitors but is also permissive for thymic natural killer (NK) cell development. Here the authors show that GATA3 directs human T-lineage commitment by modulating No
Externí odkaz:
https://doaj.org/article/69f154ad67fa47219da5b76adf207d5e
Publikováno v:
Clinical and Developmental Immunology, Vol 5, Iss 4, Pp 223-245 (1998)
Externí odkaz:
https://doaj.org/article/be9cfe12c2794de0803fc96763b4d604
Autor:
Jonathan C. Kagan, Ellen V. Rothenberg, Arthur Weiss, Alexander Y. Rudensky, Stephen T. Smale
Publikováno v:
Trends in Immunology. 44:248-255
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fda0b4a89b0b58560e141ae734b03f69
https://doi.org/10.1016/j.it.2023.02.003
https://doi.org/10.1016/j.it.2023.02.003
Publikováno v:
Immunological Reviews. 315:171-196
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22212aad9306b8c2cb518811a9aae4aa
https://doi.org/10.1111/imr.13190
https://doi.org/10.1111/imr.13190