Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Ellen Triantafellow"'
Autor:
Christine Moore, Brant Firestone, Erin P. Keaney, Dmitri Wiedershain, William E. Dowdle, Pascal Furet, Wieslawa Maniara, Edmund Harrington, Meir Glick, Ellen Triantafellow, Lawrence G. Hamann, Ivan Cornella-Taracido, Mark Knapp, Ayako Honda, Leon Murphy, Peter Finan
Publikováno v:
ACS Medicinal Chemistry Letters. 7:72-76
Autophagy is a dynamic process that regulates lysosomal-dependent degradation of cellular components. Until recently the study of autophagy has been hampered by the lack of reliable pharmacological tools, but selective inhibitors are now available to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49cd24bb742509768e4993ef945d4cf9
https://doi.org/10.1021/acsmedchemlett.5b00335
https://doi.org/10.1021/acsmedchemlett.5b00335
Autor:
Stephen B. Helliwell, Ayako Honda, Jane Nagel, Xiaohong Mao, Debra Burdick, Julie Bastien, Henry Wang, Suchithra Menon, Hong Lei, Robert Elling, William E. Dowdle, Dirksen E. Bussiere, Mary Ellen Digan, Lawrence G. Hamann, Ivan Cornella-Taracido, Beat Nyfeler, David Schwalb, Dmitri Wiederschain, Savuth Ugwonali, Fred Harbinski, Markus Schirle, Peter Fekkes, Christine D. Wilson, Shanming Liu, Thomas B. Nicholson, Edmund Harrington, Jason R. Thomas, Reginald Valdez, Vic E. Myer, Brendan D. Manning, Erin P. Keaney, John A. Tallarico, Peter Finan, Mark Labow, Gwynn Pardee, Simon D’Aquin, Andrew F. Powers, John Cantwell, Philip Bergman, Qing Fang, Leon Murphy, Zuncai Wang, Mark Knapp, Jenny Kuerth, Ellen Triantafellow, Catherine Luu, Jeffery A. Porter
Publikováno v:
Nature Cell Biology. 16:1069-1079
Cells rely on autophagy to clear misfolded proteins and damaged organelles to maintain cellular homeostasis. In this study we use the new autophagy inhibitor PIK-III to screen for autophagy substrates. PIK-III is a selective inhibitor of VPS34 that b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f2f917aae57e431c829762b739d3143
https://doi.org/10.1038/ncb3053
https://doi.org/10.1038/ncb3053
Autor:
Yanyi Zhu, Daniel J. Klionsky, Beat Nyfeler, Philip Bergman, Ellen Triantafellow, Peter Finan, Christine D. Wilson, Branko Radetich, Leon Murphy
Publikováno v:
Molecular and cellular biology. 31(14)
The mammalian target of rapamycin complex 1 (mTORC1) is a multiprotein signaling complex regulated by oncogenes and tumor suppressors. Outputs downstream of mTORC1 include ribosomal protein S6 kinase 1 (S6K1), eukaryotic translation initiation factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::746948d920b3618ac7dd524ada6e638e
https://pubmed.ncbi.nlm.nih.gov/21576371
https://pubmed.ncbi.nlm.nih.gov/21576371
Autor:
Jessica L. Yecies, Brendan D. Manning, Suchithra Menon, Pichai Raman, Clary B. Clish, Katrin Düvel, Regina Gorski, Stephen Cleaver, Qicheng Ma, Amanda Souza, Alex Lipovsky, Leon Murphy, Ellen Triantafellow, Peter Finan, Jeffrey P. MacKeigan, Matthew G. Vander Heiden
Publikováno v:
PMC
Aberrant activation of the mammalian target of rapamycin complex 1 (mTORC1) is a common molecular event in a variety of pathological settings, including genetic tumor syndromes, cancer, and obesity. However, the cell-intrinsic consequences of mTORC1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26689ea5eaed007cd215619906b22f1a
http://hdl.handle.net/1721.1/116937
http://hdl.handle.net/1721.1/116937
Autor:
Haidi Yang, Henry Wang, Vic E. Myer, Peter Finan, Ellen Triantafellow, Jeffrey P. MacKeigan, Leon Murphy, Bailin Zhang, Y. Karen Wang, Christine D. Wilson, Paul Nicklin, Philip Bergman, Jeffrey A. Porter, Beat Nyfeler, Lewis C. Cantley, Marc Hild, Charles Kung
SummaryAmino acids are required for activation of the mammalian target of rapamycin (mTOR) kinase which regulates protein translation, cell growth, and autophagy. Cell surface transporters that allow amino acids to enter the cell and signal to mTOR a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ee6418ff9d65f818a88f13aeb0d4c05
https://europepmc.org/articles/PMC3733119/
https://europepmc.org/articles/PMC3733119/
Autor:
Peter Finan, Jeffrey P. MacKeigan, Katie R. Sian, Leon Murphy, Giordano Caponigro, Jason Borawski, Natalie M. Wolters, Ellen Triantafellow, L. Alex Gaither, Winfried Elis
Publikováno v:
Molecular cancer research : MCR. 6(4)
Members of the phosphoinositide 3-kinase (PI3K) family collectively control multiple cellular responses, including proliferation, growth, chemotaxis, and survival. These diverse effects can partly be attributed to the broad range of downstream effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbe39ba3847ad8014ea588a3b01fb2b0
https://pubmed.ncbi.nlm.nih.gov/18403640
https://pubmed.ncbi.nlm.nih.gov/18403640
Autor:
Betsy Kitchens, Ellen Triantafellow, Ellis L. Reinherz, Keith D. Crawford, Baldev Vasir, Dana Gabuzda, Charles E. Larsen, Aleksandra Stark, Chester A. Alper, Vassilios Pantazopoulos, Kerry Sternheim, Zhigang Wang
Publikováno v:
Blood. 102(5)
We have shown previously that primary dendritic cells and monocytes express equal levels of CD14 but are distinguishable by the presence of CD2 on dendritic cells. CD2 is known to mediate the activation of T and natural killer (NK) cells through its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b921ba6ff24b29d607787efe8ba530c8
https://pubmed.ncbi.nlm.nih.gov/12714509
https://pubmed.ncbi.nlm.nih.gov/12714509