Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Ellen T. Koch"'
Autor:
Ellen T. Koch, Judy Cheng, Daniel Ramandi, Marja D. Sepers, Alex Hsu, Tony Fong, Timothy H. Murphy, Eric Yttri, Lynn A. Raymond
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Background Huntington disease (HD) is a neurodegenerative disorder with complex motor and behavioural manifestations. The Q175 knock-in mouse model of HD has gained recent popularity as a genetically accurate model of the human disease. Howe
Externí odkaz:
https://doaj.org/article/abbc69e7a5c44729926d173be44cabc4
Publikováno v:
Movement Disorders. 37:2021-2032
Huntington's disease is a progressive neurodegenerative disorder with no disease-modifying treatments. Patients experience motor, cognitive, and psychiatric disturbances, and the dorsal striatum is the main target of neurodegeneration. Mouse models o
Autor:
James P. Mackay, Amy I. Smith-Dijak, Ellen T. Koch, Peng Zhang, Evan Fung, Wissam B. Nassrallah, Caodu Buren, Mandi Schmidt, Michael R. Hayden, Lynn A. Raymond
Publikováno v:
The Journal of Neuroscience. :JN-RM
Action potential-independent (miniature) neurotransmission occurs at all chemical synapses, but remains poorly understood, particularly in pathological contexts. Axonal endoplasmic reticulum (ER) Ca2+stores are thought to influence miniature neurotra
Autor:
Lynn A. Raymond, Dongsheng Xiao, Timothy H. Murphy, Amy I. Smith-Dijak, Majid H. Mohajerani, James P. Mackay, Allan W. Chan, Daniel Ramandi, Ellen T. Koch, Marja D. Sepers
Huntington disease (HD), a hereditary neurodegenerative disorder, manifests as progressively impaired movement and cognition. Although early abnormalities of neuronal activity in striatum are well established in HD models, there are fewer in vivo stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a91c0581e64bb066cfd97625719de93
https://doi.org/10.1101/2021.07.18.452688
https://doi.org/10.1101/2021.07.18.452688
Autor:
Lynn A. Raymond, Ellen T. Koch
Publikováno v:
Journal of neuroscience researchREFERENCES. 97(12)
Dopamine signaling in the striatum is critical for a variety of behaviors including movement, behavioral flexibility, response to reward and many forms of learning. Alterations to dopamine transmission contribute to pathological features of many neur
Publikováno v:
Journal of neurophysiology. 120(6)
Glutamate is the main excitatory neurotransmitter in the brain, and impairments in its signaling are associated with many neurological disorders, including Huntington’s disease (HD). Previous studies in HD mouse models demonstrate altered glutamate
Publikováno v:
Current biology : CB. 26(21)
Nutrient deprivation can lead to dramatic changes in feeding behavior, including acceptance of foods that are normally rejected. In flies, this behavioral shift depends in part on reciprocal sensitization and desensitization of sweet and bitter taste