Výsledky vyhledávání - "Ellen Schrama"

Akademický článek

Immune suppression by human thymus-derived effector Tregs relies on glucose/lactate-fueled fatty acid synthesis

Autor: Sander de Kivit, Mark Mensink, Sarantos Kostidis, Rico J.E. Derks, Esther A. Zaal, Marieke Heijink, Lotte J. Verleng, Evert de Vries, Ellen Schrama, Niek Blomberg, Celia R. Berkers, Martin Giera, Jannie Borst

Publikováno v: Cell Reports, Vol 43, Iss 9, Pp 114681- (2024)

Summary: Regulatory T cells (Tregs) suppress pro-inflammatory conventional T cell (Tconv) responses. As lipids impact cell signaling and function, we compare the lipid composition of CD4+ thymus-derived (t)Tregs and Tconvs. Lipidomics reveal constitu

Externí odkaz: https://doaj.org/article/de51d349abac4044b71dadce296bbfdb

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Akademický článek

Proteomics reveals unique identities of human TGF-β-induced and thymus-derived CD4+ regulatory T cells

Autor: Mark Mensink, Ellen Schrama, Eloy Cuadrado, Derk Amsen, Sander de Kivit, Jannie Borst

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)

Abstract The CD4+ regulatory T (Treg) cell lineage, defined by FOXP3 expression, comprises thymus-derived (t)Treg cells and peripherally induced (p)Treg cells. As a model for Treg cells, studies employ TGF-β-induced (i)Treg cells generated from CD4+

Externí odkaz: https://doaj.org/article/96d2ca90a8bb41478fe864b49701dfa5

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Akademický článek

TNFR2 Costimulation Differentially Impacts Regulatory and Conventional CD4+ T-Cell Metabolism

Autor: Mark Mensink, Thi Ngoc Minh Tran, Esther A. Zaal, Ellen Schrama, Celia R. Berkers, Jannie Borst, Sander de Kivit

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

CD4+ conventional T cells (Tconvs) mediate adaptive immune responses, whereas regulatory T cells (Tregs) suppress those responses to safeguard the body from autoimmunity and inflammatory diseases. The opposing activities of Tconvs and Tregs depend on

Externí odkaz: https://doaj.org/article/e6b5975c1a8547bda3214a6cbda6d7ba

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Proteomics reveals unique identities of human TGF-β-induced and thymus-derived CD4+ regulatory T cells

Autor: Mark Mensink, Ellen Schrama, Eloy Cuadrado, Maartje van den Biggelaar, Derk Amsen, Sander de Kivit, Jannie Borst

The CD4+ regulatory T (Treg) cell lineage, as defined by FOXP3 expression, comprises thymus-derived (t)Treg cells and peripherally induced (p)Treg cells. In human, naïve tTreg cells can be isolated from blood, while effector tTreg and pTreg cells ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9a13bb221927fef374518b99732220e0
https://doi.org/10.1101/2021.10.30.466569

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The impact of cell source, culture methodology, culture location, and individual donors on gene expression profiles of bone marrow-derived and adipose-derived stromal cells

Autor: Eugène T P Verwiel, Ruurd Torensma, Anton C.M. Martens, Helene Roelofs, Ellen Schrama, Henk-Jan Prins, Bastiaan J.H. Jansen

Publikováno v: Torensma, R, Prins, H J, Schrama, E, Verwiel, E T P, Martens, A C M, Roelofs, H & Jansen, B J H 2013, ' The impact of cell source, culture methodology, culture location, and individual donors on gene expression profiles of bone marrow-derived and adipose-derived stromal cells ', Stem Cells and Development, vol. 22, no. 7, pp. 1086-1096 . https://doi.org/10.1089/scd.2012.0384
Stem Cells and Development, 22, 1086-96
Stem Cells and Development, 22, 7, pp. 1086-96
Stem Cells and Development, 22(7), 1086-1096. Mary Ann Liebert Inc.

Item does not contain fulltext Bone marrow (BM) stromal cells (MSCs), also known as mesenchymal stem cells, display a high degree of heterogeneity. To shed light on the causes of this heterogeneity, MSCs were collected from either human BM (n=5) or a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f93cf9e386ec140194d4a58d31d8f3b
https://doi.org/10.1089/scd.2012.0384

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In situ visualization of antigen-specific T cells in cryopreserved human tissues

Autor: Trees A. M. Dellemijn, Yeung-Hyen Kim, Ellen Schrama, Florry A. Vyth-Dreese, Eric Spierings, John B. A. G. Haanen, Els Goulmy

Publikováno v: Journal of Immunological Methods. 310:78-85

Tetrameric MHC/peptide complexes are important tools for analyzing antigen-specific T cells. The in situ use of tetrameric MHC/peptide complexes in viable tissue sections has several shortcomings: it does not allow the execution of multiple analyses

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55bcccd25942e892ebdcc3547589fff1
https://doi.org/10.1016/j.jim.2005.12.011

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Generation of minor histocompatibility antigen HA-1–specific cytotoxic T cells restricted by nonself HLA molecules: a potential strategy to treat relapsed leukemia after HLA-mismatched stem cell transplantation

Autor: Ellen Schrama, Tuna Mutis, Els Goulmy, Michel G.D. Kester, Els Blokland

Publikováno v: Blood, 100, 547-552

Successful stem cell transplantation (SCT) across HLA barriers can be performed with cord blood, megadoses of stem cells, or with nonmyeloablative conditioning strategies. Because the HLA-mismatched transplants are often T-cell depleted, leukemia rel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37cecb69a6845e240d5eefa9d00cbd74
https://doi.org/10.1182/blood-2002-01-0024

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Tetrameric HLA class I-minor histocompatibility antigen peptide complexes demonstrate minor histocompatibility antigen-specific cytotoxic T lymphocytes in patients with graft-versus-host disease

Autor: J.H.F. Falkenburg, Geraldine M. Gillespie, Tuna Mutis, Paul Moss, Els Goulmy, Ellen Schrama

Publikováno v: Mutis, T, Gillespie, G, Schrama, E, Falkenburg, J H F, Moss, P & Goulmy, E 1999, ' Tetrameric HLA class I-minor histocompatibility antigen peptide complexes demonstrate minor histocompatibility antigen-specific cytotoxic T lymphocytes in patients with graft-versus-host disease ', Nature Medicine, vol. 5, no. 7, pp. 839-842 . https://doi.org/10.1038/10563
Nature Medicine, 5(7), 839-842. Nature Publishing Group

Graft-versus-host disease (GvHD) is a chief complication of allogeneic bone marrow transplantation1. In HLA-identical bone marrow transplantation, GvHD may be induced by disparities in minor histocompatibility antigens (mHags) between the donor and t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e568268a6ccfc959b1b593d70848ca82
https://doi.org/10.1038/10563

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HLA Class II Restricted T-Cell Reactivity to a Developmentally Regulated Antigen Shared by Leukemic Cells and CD34+ Early Progenitor Cells

Autor: Ellen Schrama, J. H. F. Falkenburg, Cornelis J. M. Melief, Tuna Mutis, Els Goulmy, Simone A.P. van Luxemburg-Heijs

Publikováno v: Blood, 90(3), 1083-1090. American Society of Hematology
Mutis, T, Schrama, E, Van Luxemburg-Heijs, S A P, Falkenburg, J H F, Melief, C J M & Goulmy, E 1997, ' Hla class II restricted T-cell reactivity to a developmentally regulated antigen shared by leukemic cells and CD34+ early progenitor cells ', Blood, vol. 90, no. 3, pp. 1083-1090 .
Blood

After allogeneic bone marrow transplantation (BMT), the beneficial graft-versus-leukemia (GVL) effect but also the life-threatening graft-versus-host disease (GVHD) are mediated by T cells of the grafted marrow. The identification of leukemia cell–

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b007b855de2987fa009bf0e044918620
https://doi.org/10.1182/blood.v90.3.1083.1083_1083_1090

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