Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Ellen Scheers"'
Autor:
Loeckie De Zwart, Jan Snoeys, Frank Jacobs, Lilian Y. Li, Italo Poggesi, Peter Verboven, Ivo Goris, Ellen Scheers, Inneke Wynant, Mario Monshouwer, Rao N. V. S. Mamidi
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 9, Pp 1107-1118 (2021)
Abstract Erdafitinib is a potent oral pan‐fibroblast growth factor receptor inhibitor being developed as oncology drug for patients with alterations in the fibroblast growth factor receptor pathway. Erdafitinib binds preferentially to α1‐acid gl
Externí odkaz:
https://doaj.org/article/8775373d94c14cc6bf4c7d8ef15cfec3
Autor:
Frank Jacobs, Loeckie de Zwart, I. Goris, Mario Monshouwer, Rao N.V.S. Mamidi, Lilian Y. Li, Italo Poggesi, Jan Snoeys, Peter Verboven, Ellen Scheers, Inneke Wynant
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 9, Pp 1107-1118 (2021)
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 9, Pp 1107-1118 (2021)
Erdafitinib is a potent oral pan‐fibroblast growth factor receptor inhibitor being developed as oncology drug for patients with alterations in the fibroblast growth factor receptor pathway. Erdafitinib binds preferentially to α1‐acid glycoprotei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3abbc9d1666772a5a4609f5ea1cec529
https://doi.org/10.1002/psp4.12682
https://doi.org/10.1002/psp4.12682
Autor:
Italo Poggesi, Hilde Bohets, Chi Keung, Inneke Wynant, Filip Cuyckens, Rao N.V.S. Mamidi, Ellen Scheers, Laurent Leclercq, Carine Borgmans
Publikováno v:
Xenobiotica. 51:177-193
This article describes in vivo biotransformation and disposition of erdafitinib following single oral dose of 3H-erdafitinib and 14C-erdafitinib to intact and bile duct-cannulated (BC) rats (4 mg/k...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67807dfe758efa22b6eb33a179cbfda4
https://doi.org/10.1080/00498254.2020.1821123
https://doi.org/10.1080/00498254.2020.1821123
Autor:
Bhavna Solanki, Ellen Scheers, Andrew Jadwin, Rao N.V.S. Mamidi, Reyna Favis, Damayanthi Devineni, Stephan Francke
Publikováno v:
The Journal of Clinical Pharmacology. 55:1061-1072
O-glucuronidation is the major metabolic elimination pathway for canagliflozin. The objective was to identify enzymes and tissues involved in the formation of 2 major glucuronidated metabolites (M7 and M5) of canagliflozin and subsequently to assess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::619e317969d458c4a84908fae015e5d0
https://doi.org/10.1002/jcph.506
https://doi.org/10.1002/jcph.506
Autor:
Ellen Scheers, Joseph Murphy, Paul Rothenberg, Shean-Sheng Wang, Hans Stieltjes, Rao N.V.S. Mamidi, Damayanthi Devineni
Publikováno v:
Clinical Pharmacology in Drug Development. 4:295-304
Absolute oral bioavailability of canagliflozin was assessed by simultaneous oral administration with intravenous [(14) C]-canagliflozin microdose infusion in nine healthy men. Pharmacokinetics of canagliflozin, [(14) C]-canagliflozin, and total radio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3dd05f946f87a2b8667e3cdc37cf20c9
https://doi.org/10.1002/cpdd.162
https://doi.org/10.1002/cpdd.162
Autor:
Ellen Scheers, Juthamas Sukbuntherng, Nini Bode, Joseph Murphy, Jan de Jong, Donna Skee, Geert Mannens, Filip Cuyckens, Marc Bockx, Aline Laenen, Laurent Leclercq
Publikováno v:
Drug Metabolism and Disposition. 43:289-297
The absorption, metabolism, and excretion of ibrutinib were investigated in healthy men after administration of a single oral dose of 140 mg of ¹⁴C-labeled ibrutinib. The mean (S.D.) cumulative excretion of radioactivity of the dose was 7.8% (1.4%
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ea02f160f6da77e3d84d958cd71c33a
https://doi.org/10.1124/dmd.114.060061
https://doi.org/10.1124/dmd.114.060061
Autor:
Jan Snoeys, Ellen Scheers, David C. Evans, Carlo Sensenhauser, Heng-Keang Lim, Laurent Leclercq, Peter Verboven, Shannon Dallas, Michael F. Kelley, Mark D. Johnson, Filip Cuyckens, Rao N.V.S. Mamidi
Aims Canagliflozin is a recently approved drug for use in the treatment of type 2 diabetes. The potential for canagliflozin to cause clinical drug-drug interactions (DDIs) was assessed. Methods DDI potential of canagliflozin was investigated using in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd2c9abf5fb872c233c8c45485ac3e9b
https://europepmc.org/articles/PMC5401984/
https://europepmc.org/articles/PMC5401984/
Publikováno v:
Metabolite Safety in Drug Development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16330e8bbd51d117463c7169d0670781
https://doi.org/10.1002/9781118949689.ch13
https://doi.org/10.1002/9781118949689.ch13
Autor:
Ellen, Scheers, Laurent, Leclercq, Jan, de Jong, Nini, Bode, Marc, Bockx, Aline, Laenen, Filip, Cuyckens, Donna, Skee, Joe, Murphy, Juthamas, Sukbuntherng, Geert, Mannens
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 43(2)
The absorption, metabolism, and excretion of ibrutinib were investigated in healthy men after administration of a single oral dose of 140 mg of ¹⁴C-labeled ibrutinib. The mean (S.D.) cumulative excretion of radioactivity of the dose was 7.8% (1.4%
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::aad7c53b5e2b4abc196f57d90d83c0a2
https://pubmed.ncbi.nlm.nih.gov/25488930
https://pubmed.ncbi.nlm.nih.gov/25488930
Publikováno v:
Alternatives to Laboratory Animals. 30:309-312
Amino alcohols are used as emulsifying agents in dry-cleaning soaps, wax removers, cosmetics, paints and insecticides. The cytotoxicities of 12 amino alcohols, which differed in chain length, position of the amino and alcohol groups, and the presence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fffe159dfdebfa4e6c4b7cd98a0c85e2
https://doi.org/10.1177/026119290203000308
https://doi.org/10.1177/026119290203000308