Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Ellen Sanford"'
Autor:
Aleksandr Kolesnikov, Ellen Sanford, Dange Vijaykumar, Michael J. Green, Kieron E. Wesson, Jennifer R. Riggs, Paul A. Sprengeler, Troy A. Wahl, Christine Yu, William D. Shrader, Huiyong Hu, Ellen M. Leahy, Wendy B. Young, Zhiwei Tong, Brad A. Katz, Margaret Nguyen, Ronnel Cabuslay
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:3197-3200
The discovery and development of 5-azaindole factor VIIa inhibitors will be described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be6dfbca8762f93301eb848f0e0542d0
https://doi.org/10.1016/j.bmcl.2006.03.049
https://doi.org/10.1016/j.bmcl.2006.03.049
Autor:
Ellen Sanford, Roopa Rai, Steven M. Torkelson, William D. Shrader, Ronnell Cabuslay, Bradley A. Katz, Paul A. Sprengeler, Tony Ton, Aleksandr Kolesnikov, Robin Stephens, Wendy B. Young, Christine Yu, John Hendrix
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:2270-2273
Structure-activity relationships and binding mode of novel heterocyclic factor VIIa inhibitors will be described. In these inhibitors, a highly basic 5-amidinoindole moiety has been successfully replaced with a less basic 5-aminopyrrolo[3,2-b]pyridin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c66e188d0e81cf4dc4e2d539122d536
https://doi.org/10.1016/j.bmcl.2006.01.017
https://doi.org/10.1016/j.bmcl.2006.01.017
Autor:
Lin Warren, Denise Moore, Vanessa Wick, Lindsay Beaton, Paramala Santosh, Dido Green, J Ellen Sanford
Publikováno v:
British Journal of Occupational Therapy. 66:454-463
This project investigated the prevalence of sensory processing problems in a clinical group and also examined the clinical effectiveness of a specialised therapeutic technique, sensory integrative ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b71f1a8fd85be8372d931b57c8d5251
https://doi.org/10.1177/030802260306601004
https://doi.org/10.1177/030802260306601004
Autor:
Kieron E. Wesson, Ronnel Cabuslay, Erik Gjerstad, Jennifer R. Riggs, William D. Shrader, Robin Stephens, Michael J. Green, Margaret Nguyen, Ellen M. Leahy, Wendy B. Young, Aleksandr Kolesnikov, Paul A. Sprengeler, Huiyong Hu, Ellen Sanford
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(17)
The 4-amino-5-azaindole as an amidino-benzimidazole replacement is described. A series of potent and selective analogs were discovered and showed desirable ex vivo efficacy as measured by PT.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fb24d37b71e147256e78365c8178c14
https://pubmed.ncbi.nlm.nih.gov/16793264
https://pubmed.ncbi.nlm.nih.gov/16793264
Autor:
Erik Gjerstadt, Ellen Sanford, William D. Shrader, Ellen M. Leahy, Paul A. Sprengeler, Steve Torkelson, Roopa Rai, Juthamas Sukbuntherng, Huiyong Hu, Dange Vijaykumar, Ronnell Cabuslay, Colin O’Bryan, Jennifer R. Riggs, Liang Liu, Wendy B. Young, Tony Ton, Michael B. Shaghafi
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(14)
Efforts toward developing orally bioavailable factor VIIa inhibitors starting from parenteral lead compound 1 are described. SAR resulted in improved physicochemical properties, leading to enhanced oral absorption in rat.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0763c6af115b95efd98bed0abab2d60
https://pubmed.ncbi.nlm.nih.gov/16650987
https://pubmed.ncbi.nlm.nih.gov/16650987
Autor:
Ellen Sanford, Steve Torkelson, Jana Burgess-Henry, Roopa Rai, William D. Shrader, Christine Yu, Wendy B. Young, Tony Ton, Jie Tang, Ronnel Cabuslay, Bradley A. Katz, Aleksandr Kolesnikov, James W. Janc, John Hendrix, Huiyong Hu, Paul A. Sprengeler
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(6)
Within the trypsin family of coagulation proteases, obtaining highly selective inhibitors of factor VIIa has been challenging. We report a series of factor VIIa (fVIIa) inhibitors based on the 5-amidino-2-(2-hydroxy-biphenyl-3-yl)-benzimidazole (1) s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3b6aa7908cc5d32e6c98352dd3b8899
https://pubmed.ncbi.nlm.nih.gov/16413783
https://pubmed.ncbi.nlm.nih.gov/16413783