Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Ellen Reisinger"'
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Inhibitory G proteins (Gi proteins) are highly homologous but play distinct biological roles. However, their isoform-specific detection remains challenging. To facilitate the analysis of Gαi3 expression, we generated a Gnai3 - iresGFP repor
Externí odkaz:
https://doaj.org/article/109c206beb054c498b8de76fdeab599d
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Deficiency of otoferlin causes profound prelingual deafness in humans and animal models. Here, we closely analyzed developmental deficits and degenerative mechanisms in Otof knock-out (Otof–/–) mice over the course of 48 weeks. We found otoferlin
Externí odkaz:
https://doaj.org/article/b7cc15a3a0094c49896df0a707d4e557
Autor:
Hanan Al‐Moyed, Andreia P Cepeda, SangYong Jung, Tobias Moser, Sebastian Kügler, Ellen Reisinger
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 1, Pp 1-13 (2018)
Abstract Normal hearing and synaptic transmission at afferent auditory inner hair cell (IHC) synapses require otoferlin. Deafness DFNB9, caused by mutations in the OTOF gene encoding otoferlin, might be treated by transferring wild‐type otoferlin c
Externí odkaz:
https://doaj.org/article/7f7748f6cf1944a892e94a8421e932d7
Autor:
Sandra Meese, Andreia P. Cepeda, Felix Gahlen, Christopher M. Adams, Ralf Ficner, Anthony J. Ricci, Stefan Heller, Ellen Reisinger, Meike Herget
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 9 (2017)
Otoferlin is essential for fast Ca2+-triggered transmitter release from auditory inner hair cells (IHCs), playing key roles in synaptic vesicle release, replenishment and retrieval. Dysfunction of otoferlin results in profound prelingual deafness. De
Externí odkaz:
https://doaj.org/article/24114096d00b4d8cb595cc8804cae68c
Publikováno v:
Genes
The OTOF gene encodes otoferlin, a critical protein at the synapse of auditory sensory cells, the inner hair cells (IHCs). In the absence of otoferlin, signal transmission of IHCs fails due to impaired release of synaptic vesicles at the IHC synapse.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::10e5e18fcac5a7a66a939ad07ba8ab6c
https://pubmed.ncbi.nlm.nih.gov/33256196
https://pubmed.ncbi.nlm.nih.gov/33256196
Autor:
Ellen Reisinger
Publikováno v:
Hearing research. 394
Adeno-associated viruses (AAVs) are preferred vectors for gene replacement therapy, as they are non-pathogenic, non-inflammatory, induce stable transgene expression in terminally differentiated cells, and a series of natural and engineered capsid pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11ab09c900852eb08d36601eef087c62
https://pubmed.ncbi.nlm.nih.gov/31810595
https://pubmed.ncbi.nlm.nih.gov/31810595
Publikováno v:
Abstract- und Posterband – 90. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn – Digitalisierung in der HNO-Heilkunde.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f73b713785b24bc94f6210f217fad816
https://doi.org/10.1055/s-0039-1686252
https://doi.org/10.1055/s-0039-1686252
Publikováno v:
Abstract- und Posterband – 90. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn – Digitalisierung in der HNO-Heilkunde.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3985b1881b2a3ba2e3d21f6fba56549
https://doi.org/10.1055/s-0039-1686481
https://doi.org/10.1055/s-0039-1686481
Autor:
Andreia P. Cepeda, Sebastian Kügler, Ellen Reisinger, SangYong Jung, Hanan Al-Moyed, Tobias Moser
Publikováno v:
EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 11, Iss 1, Pp n/a-n/a (2019)
EMBO Molecular Medicine, Vol 11, Iss 1, Pp n/a-n/a (2019)
Normal hearing and synaptic transmission at afferent auditory inner hair cell (IHC) synapses require otoferlin. Deafness DFNB9, caused by mutations in the OTOF gene encoding otoferlin, might be treated by transferring wild‐type otoferlin cDNA into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a01645569d81d85845e85e39ac517075
https://pubmed.ncbi.nlm.nih.gov/30573543
https://pubmed.ncbi.nlm.nih.gov/30573543
Autor:
Amy J. Starmer, Gabriella Ika Kovacikova, Ellen Reisinger, Corinna J. Rea, Joanne E. Cox, Eli Sprecher, Hannah Durant, Kathleen Conroy, Sara L. Toomey
Publikováno v:
Pediatrics. 142
BACKGROUND AND OBJECTIVES:Timely provision of developmental services can improve outcomes for children 0 to 3 years old with developmental delays. Early Intervention (EI) provides free developmental services to children under age 3 years; however, da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42886f36a78b7c4952bb7b8b05c3b9e5
https://doi.org/10.1542/peds.2017-4017
https://doi.org/10.1542/peds.2017-4017