Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Ellen Orthey"'
Autor:
Niels Pietsch, Jiancheng Cheng, Antonietta Fazio, Leonie Ewald, Erda Alizoti, Elisabeth Krämer, Ellen Orthey, Lucie Carrier, Sonia R Singh
Publikováno v:
Stem Cell Research, Vol 71, Iss , Pp 103188- (2023)
Variants in CRYAB can lead to desmin-related (cardio-)myopathy (DRM), a genetic muscle disorder with no curative treatment available. We introduced a homozygous CRYAB c.358G > A (p.Arg120Gly) mutation, which is established for the study of DRM in mic
Externí odkaz:
https://doaj.org/article/690b5a4cbefd4b42b1db8d1852a43c94
Autor:
Antonia T. L. Zech, Maksymilian Prondzynski, Sonia R. Singh, Niels Pietsch, Ellen Orthey, Erda Alizoti, Josefine Busch, Alexandra Madsen, Charlotta S. Behrens, Moritz Meyer-Jens, Giulia Mearini, Marc D. Lemoine, Elisabeth Krämer, Diogo Mosqueira, Sanamjeet Virdi, Daniela Indenbirken, Maren Depke, Manuela Gesell Salazar, Uwe Völker, Ingke Braren, William T. Pu, Thomas Eschenhagen, Elke Hammer, Saskia Schlossarek, Lucie Carrier
Publikováno v:
Cells, Vol 11, Iss 17, p 2745 (2022)
Genetic variants in α-actinin-2 (ACTN2) are associated with several forms of (cardio)myopathy. We previously reported a heterozygous missense (c.740C>T) ACTN2 gene variant, associated with hypertrophic cardiomyopathy, and characterized by an electro
Externí odkaz:
https://doaj.org/article/109fa3ab16674cf981367758f4aa3eb1
Autor:
Erda Alizoti, Lysa Michler, Ellen Orthey, Hanna Osinska, James Gulick, Birgit Klampe, Thomas Schulze, Arne Hansen, Saskia Schlossarek, Lucy Carrier, Patrick McLendon, Jeffrey Robbins, Sonia Singh
Publikováno v:
Journal of Molecular and Cellular Cardiology. 173:95-96
Autor:
Antonia T. L. Zech, Maksymilian Prondzynski, Sonia R. Singh, Ellen Orthey, Erda Alizoti, Josefine Busch, Alexandra Madsen, Charlotta S. Behrens, Giulia Mearini, Marc D. Lemoine, Elisabeth Krämer, Diogo Mosqueira, Sanamjeet Virdi, Daniela Indenbirken, Maren Depke, Manuela Gesell Salazar, Uwe Völker, Ingke Braren, William T. Pu, Thomas Eschenhagen, Elke Hammer, Saskia Schlossarek, Lucie Carrier
Genetic variants in α-actinin-2 (ACTN2) are associated with several forms of (cardio)myopathy. We previously reported a heterozygous missense (c.740C>T) ACTN2 gene variant, associated with hypertrophic cardiomyopathy, and characterized by an electro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4de4d821144b4a5d36d21f3d0d284ec
https://doi.org/10.1101/2021.10.28.466251
https://doi.org/10.1101/2021.10.28.466251
Autor:
Niels Pietsch, Antonietta Fazio, Jiancheng Cheng, Ellen Orthey, Elisabeth Krämer, Saskia Schlossarek, Lucie Carrier, Sonia Singh
Publikováno v:
Journal of Molecular and Cellular Cardiology. 173:112
Autor:
Hanna Osinska, Ellen Orthey, Jeffery D. Molkentin, Saskia Schlossarek, Jeffrey Robbins, Erda Alizoti, Sonia R. Singh, James Gulick, W. Clark Bacon, Moritz Meyer-Jens, Lucie Carrier, Gregory Davis, Silke Reischmann-Düsener, Patrick M. McLendon
Publikováno v:
Autophagy
article-version (VoR) Version of Record
article-version (VoR) Version of Record
The ubiquitin-proteasome system (UPS) and autophagy-lysosomal pathway (ALP) are two major protein degradation pathways in eukaryotic cells. Initially considered as two independent pathways, there is emerging evidence that they can work in concert. As
Autor:
Tim Magnus, Anna Weymar, Joachim Velden, Olga Simova, Thiruma V. Arumugam, Manuel A. Friese, Christian Bernreuther, Immo Prinz, Mathias Gelderblom, Markus Glatzel, Ellen Orthey, Christian Gerloff, Priyadharshini Arunachalam, Christoph Hölscher, Vivien Thom, Thomas Korn, Frank Leypoldt, Eva Tolosa, Karin Steinbach
Publikováno v:
Blood. 120:3793-3802
The devastating effect of ischemic stroke is attenuated in mice lacking conventional and unconventional T cells, suggesting that inflammation enhances tissue damage in cerebral ischemia. We explored the functional role of αβ and γδ T cells in a m
Autor:
Ellen Orthey, Hasso Scholz, Gerrit Fleige, Clemens Mittmann, Joachim Weil, Thomas Eschenhagen
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 275:H378-H384
The enkephalins are derived from a common precursor protein known as preproenkephalin (ppENK). Enkephalins appear to be one of the endogenous ligands for the opiate receptors. In the rat the ventricular myocardium contains more ppENK mRNA than any ot
Autor:
Ellen Orthey, Joachim Weil, Hasso Scholz, Thomas Eschenhagen, Günter Scholtysik, Clemens Mittmann, Hansjörg Schäfer, Olaf Magnussen
Publikováno v:
Journal of Molecular and Cellular Cardiology. 29:743-751
Myoglobin levels are decreased in various animal models of heart failure, a change that has been associated with compromised energy supply. The underlying mechanisms by which myoglobin content decreases in failing myocardium are unknown. Bovine hered
Autor:
Chi-Un Choe, Dominic A. Siler, Karin Steinbach, Doerthe Behrens, Thiruma V. Arumugam, Tim Magnus, Mathias Gelderblom, Ellen Orthey, Christian Gerloff, Frank Leypoldt, Eva Tolosa
Publikováno v:
Stroke. 40(5)
Background and Purpose— Ischemic stroke leads to significant morbidity and mortality in the Western world. Early reperfusion strategies remain the treatment of choice but can initiate and augment an inflammatory response causing secondary brain dam