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Publikováno v: WIREs Systems Biology and Medicine. 1:107-115

The NF-κB transcription factor is a critical regulator of the immune system, and is responsive to a large number of stimuli. Different stimuli engage signaling pathways to activate NF-κB, and effect distinct cellular responses. Mathematical modelin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d81c02650f4ba941e771cc7da729570
https://doi.org/10.1002/wsbm.30

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UV as an Amplifier Rather Than Inducer of NF-κB Activity

Autor: Jeffrey D. Kearns, Alexander Hoffmann, Ellen O'Dea

Publikováno v: Molecular Cell. 30(5):632-641

Inflammatory activation of NF-kappaB involves the stimulus-induced degradation of the NF-kappaB-bound inhibitor IkappaB via the IkappaB kinase (IKK). In response to UV irradiation, however, the mechanism and function of NF-kappaB activation remain un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecda2b3d47234a6a6b607f1cf7517d18

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Primary care and youth mental health in Ireland:qualitative study in deprived urban areas

Publikováno v: BMC Family Practice

peer-reviewed Background: Mental disorders account for six of the 20 leading causes of disability worldwide with a very high prevalence of psychiatric morbidity in youth aged 15–24 years. However, healthcare professionals are faced with many challe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7753588205d25ff3b157c9d2fb8a19ec

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Differential activation and antagonistic function of HIF-{alpha} isoforms in macrophages are essential for NO homeostasis

Autor: Andrew L. Doedens, Jung Whan Kim, Randall S. Johnson, Ellen O'Dea, Alexander Hoffmann, Norihiko Takeda, Christian Stockmann, Alexander Weidemann, Masataka Asagiri, M. Celeste Simon

Publikováno v: Genesdevelopment. 24(5)

Hypoxic response and inflammation both involve the action of the hypoxia-inducible transcription factors HIF-1alpha and HIF-2alpha. Previous studies have revealed that both HIF-alpha proteins are in a number of aspects similarly regulated post-transl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a45ab2bbc42e86f32869753c7007a7d
https://pubmed.ncbi.nlm.nih.gov/20194441

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The regulatory logic of the NF-kappaB signaling system

Autor: Ellen O'Dea, Alexander Hoffmann

Publikováno v: Cold Spring Harbor perspectives in biology. 2(1)

NF-kappaB refers to multiple dimers of Rel homology domain (RHD) containing polypeptides, which are controlled by a stimulus-responsive signaling system that mediates the physiological responses to inflammatory intercellular cytokines, pathogen expos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c02e5a4e4e37bb2d27b83fa537562437
https://pubmed.ncbi.nlm.nih.gov/20182598

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Encoding NF-κB temporal control in response to TNF: distinct roles for the negative regulators IκBα and A20

Autor: Ellen O'Dea, Alexander Hoffmann, Averil Ma, Victoria Zadorozhnaya, Shannon L. Werner, Candace Lynch, David Baltimore, Mark Boldin, Jeffrey D. Kearns

TNF-induced NF-κB activity shows complex temporal regulation whose different phases lead to distinct gene expression programs. Combining experimental studies and mathematical modeling, we identify two temporal amplification steps—one determined by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8f9ad0c59548cf585874b70e1306451
https://europepmc.org/articles/PMC2492747/

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NF-κB dictates the degradation pathway of IκBα

Autor: Alexander Hoffmann, Gourisankar Ghosh, Erika Mathes, Ellen O'Dea

IκB proteins are known as the regulators of NF‐κB activity. They bind tightly to NF‐κB dimers, until stimulus‐responsive N‐terminal phosphorylation by IKK triggers their ubiquitination and proteasomal degradation. It is known that IκBα i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d19f173fd75d9fa72595c351c0af5e34
https://europepmc.org/articles/PMC2374850/

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A homeostatic model of IκB metabolism to control constitutive NF-κB activity

Autor: Ellen O'Dea, Andre Levchenko, Shannon L. Werner, Derren Barken, Raechel Q Peralta, Kim T Tran, Alexander Hoffmann, Jeffrey D. Kearns

Publikováno v: Molecular Systems Biology

Cellular signal transduction pathways are usually studied following administration of an external stimulus. However, disease-associated aberrant activity of the pathway is often due to misregulation of the equilibrium state. The transcription factor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6a7394238c2c226f90b653ca4454ff2
http://europepmc.org/articles/PMC2673708

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