Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Ellen Ngar Yun Poon"'
Autor:
Chi Zhang, Kathy Yuen Yee Chan, Wing Hei Ng, John Tak Kit Cheung, Qiwei Sun, Han Wang, Po Yee Chung, Frankie Wai Tsoi Cheng, Alex Wing Kwan Leung, Xiao-Bing Zhang, Po Yi Lee, Siu Ping Fok, Guanglan Lin, Ellen Ngar Yun Poon, Jian-Hua Feng, Yan-Lai Tang, Xue-Qun Luo, Li-Bin Huang, Wei Kang, Patrick Ming Kuen Tang, Junbin Huang, Chun Chen, Junchao Dong, Ester Mejstrikova, Jiaoyang Cai, Yu Liu, Shuhong Shen, Jun J Yang, Patrick Man Pan Yuen, Chi Kong Li, Kam Tong Leung
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
Resistance to glucocorticoids (GCs), the common agents for remission induction in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL), poses a significant therapeutic hurdle. Therefore, dissecting the mechanisms shaping GC resistance co
Externí odkaz:
https://doaj.org/article/b91b2983d67042199d70adb7860fbe66
Autor:
Sheng Zhu, Anna Hing Yee Law, Ruixia Deng, Ellen Ngar Yun Poon, Chun Wai Lo, Anna Ka Yee Kwong, Rui Liang, Kelvin Yuen Kwong Chan, Wai Lap Wong, Kian Cheng Tan-Un, W.W.M. Pim Pijnappel, Godfrey Chi Fung Chan, Sophelia Hoi Shan Chan
Publikováno v:
Stem Cell Research, Vol 49, Iss , Pp 102040- (2020)
We derived an integration-free induced pluripotent stem cell (iPSC) line from the peripheral blood mononuclear cells (PBMCs) of a 23-year-old male patient. This patient carries a 5′ splice site point mutation in intron 1 (c.31+1G>A) of the dystroph
Externí odkaz:
https://doaj.org/article/3ee2da2e3be0433e8b7b3b7d3239f0dd
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1912 (2022)
Anthracyclines, such as doxorubicin, are effective chemotherapeutic agents for the treatment of cancer, but their clinical use is associated with severe and potentially life-threatening cardiotoxicity. Despite decades of research, treatment options r
Externí odkaz:
https://doaj.org/article/639c72e10c4c4ee3b99a3d232a784903
Autor:
Kam Tong Leung, Alex Wing Kwan Leung, Chi-kong Li, Patrick Man Pan Yuen, Chun Chen, Junbin Huang, Qi Zhao, Ellen Ngar Yun Poon, Raymond S.M. Wong, Wayne Yuk Wai Lee, Ka-Fai To, Wei Kang, Patrick Ming-Kuen Tang, Wing Hei Ng, John Tak Kit Cheung, Yaqun Xu, Chi Zhang, Qiwei Sun, Yuet Ping Yuen, Chi Chiu So, Xiao-Bing Zhang, Tao Zhang, Chi Chiu Wang, Anskar Y.H. Leung, Wing Hang Leung, Alan K.S. Chiang, Shau Yin Ha, Tin Wai Chow, Grace Kee See Lam, Frankie Wai Tsoi Cheng, Po Yi Lee, Margaret H.L. Ng, Chi Keung Cheng, Kathy Yuen Yee Chan, Han Wang
Supplementary Data from Pharmacogenomic Profiling of Pediatric Acute Myeloid Leukemia to Identify Therapeutic Vulnerabilities and Inform Functional Precision Medicine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::340814653f430c54d027ddfe44a87c37
https://doi.org/10.1158/2643-3230.22545317.v1
https://doi.org/10.1158/2643-3230.22545317.v1
Autor:
Kam Tong Leung, Alex Wing Kwan Leung, Chi-kong Li, Patrick Man Pan Yuen, Chun Chen, Junbin Huang, Qi Zhao, Ellen Ngar Yun Poon, Raymond S.M. Wong, Wayne Yuk Wai Lee, Ka-Fai To, Wei Kang, Patrick Ming-Kuen Tang, Wing Hei Ng, John Tak Kit Cheung, Yaqun Xu, Chi Zhang, Qiwei Sun, Yuet Ping Yuen, Chi Chiu So, Xiao-Bing Zhang, Tao Zhang, Chi Chiu Wang, Anskar Y.H. Leung, Wing Hang Leung, Alan K.S. Chiang, Shau Yin Ha, Tin Wai Chow, Grace Kee See Lam, Frankie Wai Tsoi Cheng, Po Yi Lee, Margaret H.L. Ng, Chi Keung Cheng, Kathy Yuen Yee Chan, Han Wang
Despite the expanding portfolio of targeted therapies for adults with acute myeloid leukemia (AML), direct implementation in children is challenging due to inherent differences in underlying genetics. Here we established the pharmacologic profile of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41072df45b1d12a7e0dd4c70d3befc4e
https://doi.org/10.1158/2643-3230.c.6550904
https://doi.org/10.1158/2643-3230.c.6550904
Autor:
Kam Tong Leung, Alex Wing Kwan Leung, Chi-kong Li, Patrick Man Pan Yuen, Chun Chen, Junbin Huang, Qi Zhao, Ellen Ngar Yun Poon, Raymond S.M. Wong, Wayne Yuk Wai Lee, Ka-Fai To, Wei Kang, Patrick Ming-Kuen Tang, Wing Hei Ng, John Tak Kit Cheung, Yaqun Xu, Chi Zhang, Qiwei Sun, Yuet Ping Yuen, Chi Chiu So, Xiao-Bing Zhang, Tao Zhang, Chi Chiu Wang, Anskar Y.H. Leung, Wing Hang Leung, Alan K.S. Chiang, Shau Yin Ha, Tin Wai Chow, Grace Kee See Lam, Frankie Wai Tsoi Cheng, Po Yi Lee, Margaret H.L. Ng, Chi Keung Cheng, Kathy Yuen Yee Chan, Han Wang
Supplementary Figure from Pharmacogenomic Profiling of Pediatric Acute Myeloid Leukemia to Identify Therapeutic Vulnerabilities and Inform Functional Precision Medicine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::242d586dd08c36ec116ff3489f689f1d
https://doi.org/10.1158/2643-3230.22545314
https://doi.org/10.1158/2643-3230.22545314
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 473:1023-1039
Human pluripotent stem cells (hPSC) self-renew and represent a potentially unlimited source for the production of cardiomyocytes (CMs) suitable for studies of human cardiac development, drug discovery, cardiotoxicity testing, and disease modelling an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::addf539f49dc5a0f04afbbf10918a9df
https://doi.org/10.1007/s00424-021-02549-8
https://doi.org/10.1007/s00424-021-02549-8
Autor:
Kathy Yuen Yee Chan, Po Yee Chung, Chi Zhang, Ellen Ngar Yun Poon, Alex Wing Kwan Leung, Kam Tong Leung
Publikováno v:
Journal of leukocyte biologyREFERENCES. 112(4)
G-protein-coupled receptors (GPCRs) are the largest and most diverse group of membrane receptors. They are involved in almost every physiologic process and consequently have a pivotal role in an extensive number of pathologies, including genetic, neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7868ef468cc2f793f7feac32121b63cf
https://pubmed.ncbi.nlm.nih.gov/35694792
https://pubmed.ncbi.nlm.nih.gov/35694792
Autor:
Han Wang, Kathy Yuen Yee Chan, Chi Keung Cheng, Margaret H.L. Ng, Po Yi Lee, Frankie Wai Tsoi Cheng, Grace Kee See Lam, Tin Wai Chow, Shau Yin Ha, Alan K.S. Chiang, Wing Hang Leung, Anskar Y.H. Leung, Chi Chiu Wang, Tao Zhang, Xiao-Bing Zhang, Chi Chiu So, Yuet Ping Yuen, Qiwei Sun, Chi Zhang, Yaqun Xu, John Tak Kit Cheung, Wing Hei Ng, Patrick Ming-Kuen Tang, Wei Kang, Ka-Fai To, Wayne Yuk Wai Lee, Raymond S.M. Wong, Ellen Ngar Yun Poon, Qi Zhao, Junbin Huang, Chun Chen, Patrick Man Pan Yuen, Chi-kong Li, Alex Wing Kwan Leung, Kam Tong Leung
Publikováno v:
Blood cancer discovery. 3(6)
Despite the expanding portfolio of targeted therapies for adults with acute myeloid leukemia (AML), direct implementation in children is challenging due to inherent differences in underlying genetics. Here we established the pharmacologic profile of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ca555489fe5f18c2d08b830dac9f9f2
https://pubmed.ncbi.nlm.nih.gov/35960210
https://pubmed.ncbi.nlm.nih.gov/35960210
Autor:
Karen Li, Ka Fai To, Ellen Ngar Yun Poon, Margaret H.L. Ng, Tak Yeung Leung, Han Wang, Chi Zhang, King Yiu Lee, Kam Tong Leung, Chun Chen, Cheuk-Kwong Lee, Patrick Ming-Kuen Tang, Wing Hei Ng, Alex Wing Kwan Leung, Patrick Man Pan Yuen, Kathy Yuen Yee Chan, Chi Chiu Wang, Chi Kong Li, Pak Cheung Ng, Yorky Tsin Sik Wong, Xiao-Bing Zhang, Siu Ping Fok, Wei Kang, Bo Feng, Hugh Simon Lam
Publikováno v:
Blood Advances
Key Points Specific R4 RGS members are expressed in human HSPCs and regulated by the SDF-1/CXCR4 axis.RGS1/13/16 suppress HSPC engraftment, SDF-1 signaling, and key effectors of stem cell trafficking/maintenance.
Visual Abstract
Homing and
Visual Abstract
Homing and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3fff6844ffe044612e1d8de4ceb6050
https://pubmed.ncbi.nlm.nih.gov/34500454
https://pubmed.ncbi.nlm.nih.gov/34500454