Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Ellen M. Dobrusin"'
Autor:
Ellen M. Dobrusin, Elizabeth A. Lunney, William A. Denny, Edward N. Baker, Andrew M. Thompson, R. John Booth, Brian D. Palmer, John Quin, Alan J. Kraker, Christopher J. Squire, Ivan Ivanovic, Daniel F. Ortwine, Ho H. Lee, Jeff B. Smaill, James M. J. Dickson, Alexander James Bridges
Publikováno v:
European Journal of Medicinal Chemistry. 43:1276-1296
A series of N-6 substituted 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones were prepared from N-substituted (5-methoxyphenyl)ethenylindoles. The target compounds were tested for their ability to inhibit the G2/M cell cycle checkpoint kin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98017342f5dd35f584a09baa12e3d433
https://doi.org/10.1016/j.ejmech.2007.07.016
https://doi.org/10.1016/j.ejmech.2007.07.016
Autor:
Juswinder Singh, and Adrian Whitty, Fry David William, Mcnamara Dennis Joseph, Ellen M. Dobrusin, Taraneh Haske
Publikováno v:
Journal of Medicinal Chemistry. 40:1130-1135
We report the use of structure-based drug design to create a selective erbB-1 (a.k.a. epidermal growth factor receptor) and erbB-2 (a.k.a. neu/her2 growth factor receptor) tyrosine kinase inhibitor. Using the X-ray crystal structure of the ternary co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ed94729a0a9c80b1ee60f4d593dcdcd
https://doi.org/10.1021/jm960380s
https://doi.org/10.1021/jm960380s
Autor:
Alan J. Kraker, Ellen M. Dobrusin, David W. Fry, Gordon W. Rewcastle, Brian Desmond Palmer, William A. Denny
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5007352bca1782a00b6edcd828ff791
https://doi.org/10.1002/chin.199450135
https://doi.org/10.1002/chin.199450135
Autor:
William A. Denny, Alan J. Kraker, Brian D. Palmer, Lorna Helen Mitchell, R. John Booth, Leesa M Swan, Andrew M. Thompson, Ellen M. Dobrusin, Ho H. Lee, Daniel F. Ortwine, Jeff B. Smaill, Elizabeth A. Lunney
Publikováno v:
Journal of medicinal chemistry. 49(16)
High-throughput screening has identified a novel class of inhibitors of the checkpoint kinase Wee1, which have potential for use in cancer chemotherapy. These inhibitors are based on a 4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione template and hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd064ba112ca8cfc329d7dc6fe2d4ac6
https://pubmed.ncbi.nlm.nih.gov/16884302
https://pubmed.ncbi.nlm.nih.gov/16884302
Autor:
Scott N, VanderWel, Patricia J, Harvey, Dennis J, McNamara, Joseph T, Repine, Paul R, Keller, John, Quin, R John, Booth, William L, Elliott, Ellen M, Dobrusin, David W, Fry, Peter L, Toogood
Publikováno v:
Journal of medicinal chemistry. 48(7)
Inhibition of the cell cycle kinase, cyclin-dependent kinase-4 (Cdk4), is expected to provide an effective method for the treatment of proliferative diseases such as cancer. The pyrido[2,3-d]pyrimidin-7-one template has been identified previously as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ae60a75b7af5dbab61af77c34dbecd70
https://pubmed.ncbi.nlm.nih.gov/15801830
https://pubmed.ncbi.nlm.nih.gov/15801830
Autor:
David W. Fry, Inderjit Singh, Patricia J. Harvey, Rajeshwar Singh, Ellen M. Dobrusin, Ronald G. Micetich, Peter L. Toogood, Paul R. Keller, Yadagiri Bathini
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(17)
The inhibition of cyclin-dependent kinase 4 (Cdk4) causes cell cycle arrest and restores a checkpoint that is absent in the majority of tumor cells. Compounds that inhibit Cdk4 selectively are targeted for treating cancer. Appropriate substitution of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d78f82bb39a1aec85348660b1cd69d67
https://pubmed.ncbi.nlm.nih.gov/15993068
https://pubmed.ncbi.nlm.nih.gov/15993068
Autor:
Jeffrey Bruce Smaill, Brian D. Palmer, Alexander James Bridges, Bill J. Roberts, James M. Nelson, David W. Fry, Ellen M. Dobrusin, Gordon W. Rewcastle, R. T. Winters, W. L. Elliot, H. D. H. Showalter, S. J. Patmore, Patrick W. Vincent, William A. Denny, Zhou Hairong, W. R. Leopold, Dennis J. McNamara, V. Slintak
Publikováno v:
Journal of medicinal chemistry. 42(10)
A series of 6- and 7-acrylamide derivatives of the 4-(phenylamino)quinazoline and -pyridopyrimidine classes of epidermal growth factor receptor (EGFR) inhibitors were prepared from the corresponding amino compounds by reaction with either acryloyl ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97436fcf0b3737c2c47c6ea5c3bc1d50
https://pubmed.ncbi.nlm.nih.gov/10346932
https://pubmed.ncbi.nlm.nih.gov/10346932