Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Ellen M Younkin"'
Autor:
Joseph A Stewart, Michael B Hillegass, Joseph H Oberlitner, Ellen M Younkin, Beth F Wasserman, Anne M Casper
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 11, Iss 10 (2021)
AbstractLong-tract gene conversions (LTGC) can result from the repair of collapsed replication forks, and several mechanisms have been proposed to explain how the repair process produces this outcome. We studied LTGC events produced from repair colla
Externí odkaz:
https://doaj.org/article/bd2f190a98784d528e1766c001d313b5
Publikováno v:
PLoS Genetics, Vol 9, Iss 9, p e1003817 (2013)
Loss of heterozygosity (LOH) at tumor suppressor loci is a major contributor to cancer initiation and progression. Both deletions and mitotic recombination can lead to LOH. Certain chromosomal loci known as common fragile sites are susceptible to DNA
Externí odkaz:
https://doaj.org/article/d091f9fcc4f84ef2bb871f89b56c8852
Autor:
Jeanmarie D Mishler, Anne M. Casper, Ellen M Younkin, Mikael K Dunn, Shahana A Chumki, Thomas F Coates
Replication stress causes breaks at chromosomal locations called common fragile sites. Deletions causing loss of heterozygosity (LOH) in human tumors are strongly correlated with common fragile sites, but the role of gene conversion in LOH at fragile
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be1030ae5f92f0feb225fda192afd9a9
https://europepmc.org/articles/PMC5012379/
https://europepmc.org/articles/PMC5012379/
Autor:
Ellen M. Younkin, Peter A. Ward, Gabriel A. Valencia, Firas S. Zetoune, Marc Mickiewicz, John G. Younger, J. Vidya Sarma, Theodore J. Standiford, Adam S. Brinkman, Sunita Shankar-Sinha
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 29:432-438
Complement is necessary for defense against lung infection with Pseudomonas aeruginosa in mice. We studied in vitro interactions between complement and P. aeruginosa and in vivo effects of complement depletion to better understand this relationship.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70ec4ab7c15d088d9cdbfd90b423abf9
https://doi.org/10.1165/rcmb.2002-0145oc
https://doi.org/10.1165/rcmb.2002-0145oc
Autor:
Joseph Paulauskis, Firas S. Zetoune, Vidya Sarma, Ines J. Laudes, Renfeng Guo, Niels C. Riedemann, Ellen M. Younkin, Jayne S. Reuben, Kurt D. Bernacki, Thomas A. Neff, Peter A. Ward
Publikováno v:
The FASEB Journal. 17:1-17
Complement fragment 5a (C5a)-C5a receptor (C5aR) signaling plays an essential role in neutrophil innate immunity. Blockade of either the ligand or the receptor improves survival rates in experimental sepsis. In the current study, sepsis was induced i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40b5b6c1c70a9fdda64d886075333440
https://doi.org/10.1096/fj.03-0009fje
https://doi.org/10.1096/fj.03-0009fje
Autor:
Niels C. Riedeman, Ren Feng Guo, J. Vidya Sarma, John D. Lambris, Ellen M. Younkin, Ines J. Laudes, Lynn A. Spruce, Dimitrios C. Mastellos, Stephanie R. McGuire, Vaishalee A. Padgaonkar, Peter A. Ward, Thomas A. Neff, Firas S. Zetoune, Kristina T. Lu, Markus Huber-Lang
Publikováno v:
The FASEB Journal. 16:1567-1574
Innate immune functions are known to be compromised during sepsis, often with lethal consequences. There is also evidence in rats that sepsis is associated with excessive complement activation and generation of the potent anaphylatoxin C5a. In the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b4dd0b7bfdb02f17bee40690e06b415
https://doi.org/10.1096/fj.02-0209com
https://doi.org/10.1096/fj.02-0209com
Autor:
Vaishalee A. Padgaonkar, Peter A. Ward, Richard W. Erickson, John T. Curnutte, J. Vidya Sarma, Markus Huber-Lang, Kristina T. Lu, Ellen M. Younkin, Stephanie R. McGuire, Ren Feng Guo
Publikováno v:
The Journal of Immunology. 169:3223-3231
This study defines the molecular basis for defects in innate immunity involving neutrophils during cecal ligation/puncture (CLP)-induced sepsis in rats. Blood neutrophils from CLP rats demonstrated defective phagocytosis and defective assembly of NAD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59a6f067339e00d3ddbb842a9b9d5d8e
https://doi.org/10.4049/jimmunol.169.6.3223
https://doi.org/10.4049/jimmunol.169.6.3223
Autor:
Ellen M. Younkin, Peter A. Ward, Vidya Sarma, John G. Younger, Ronald B. Hirschl, Rosemarie Fernandez
Publikováno v:
Journal of Applied Physiology. 91:1941-1947
Liquid ventilation with perflubron is associated with reduced neutrophil recruitment into the lung during acute injury. Perflubron also reduces chemotactic responses, the respiratory burst, and cytokine production in neutrophils and in alveolar macro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0afcbdf3694cb97540d0071b6da8a96e
https://doi.org/10.1152/jappl.2001.91.5.1941
https://doi.org/10.1152/jappl.2001.91.5.1941
Autor:
Ellen M. Younkin, James Varani, Kent J. Johnson, Clarence S. Lewis, Roscoe L. Warner, Luis Beltran, Stephen J. Weiss
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 24:537-544
Matrix metalloproteinases (MMPs) are upregulated locally in sites of inflammation, including the lung. Several MMP activities are upregulated in acute lung injury models but the exact role that these MMPs play in the development of the lung injury is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b32658179aeac1750c4dd634050d441
https://doi.org/10.1165/ajrcmb.24.5.4160
https://doi.org/10.1165/ajrcmb.24.5.4160
Autor:
Ellen M. Younkin, Renfeng Guo, Clarence S. Lewis, Roscoe L. Warner, Kent J. Johnson, James Varani, Luis Beltran, Nicolas M. Bless
Publikováno v:
Free Radical Biology and Medicine. 29:8-16
Rats were subjected to acute lung injury by the intra-alveolar formation of IgG immune complexes of bovine serum albumin (BSA) and anti-BSA. In this model of injury, complement activation occurs and large numbers of neutrophils invade the interstitiu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fb2a68924648291d956923220582135
https://doi.org/10.1016/s0891-5849(00)00282-3
https://doi.org/10.1016/s0891-5849(00)00282-3