Výsledky vyhledávání - "Ellen M Unterwald"

Akademický článek

Generation of G protein-coupled receptor antibodies differentially sensitive to conformational states.

Autor: Andrea S Heimann, Achla Gupta, Ivone Gomes, Rahman Rayees, Avner Schlessinger, Emer S Ferro, Ellen M Unterwald, Lakshmi A Devi

Publikováno v: PLoS ONE, Vol 12, Iss 11, p e0187306 (2017)

The N-terminal region of G protein-coupled receptors can be efficiently targeted for the generation of receptor-selective antibodies. These antibodies are useful for the biochemical characterization of the receptors. In this study, we developed a set

Externí odkaz: https://doaj.org/article/a02462ed03164899bafd13870378401e

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Akademický článek

The GSK3 signaling pathway is activated by cocaine and is critical for cocaine conditioned reward in mice.

Autor: Jonathan S Miller, Jeffrey L Barr, Lauren J Harper, Rachel L Poole, Thomas J Gould, Ellen M Unterwald

Publikováno v: PLoS ONE, Vol 9, Iss 2, p e88026 (2014)

The Akt - GSK3 signaling pathway has been recently implicated in psychostimulant-induced behavioral and cellular effects. Here, the ability of cocaine to regulate the activity of Akt and GSK3 was investigated by measuring the phosphorylation states o

Externí odkaz: https://doaj.org/article/d4b567fb87404a50bc2ad13d8c19f62b

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Akademický článek

Tissue Kallikrein-1 Suppresses Type I Interferon Responses and Reduces Depressive-Like Behavior in the MRL/lpr Lupus-Prone Mouse Model

Autor: Priyanka S. Bhoj, Cassandra Nocito, Namdev S. Togre, Malika Winfield, Cody Lubinsky, Sabeeya Khan, Nikhita Mogadala, Alecia Seliga, Ellen M. Unterwald, Yuri Persidsky, Uma Sriram

Publikováno v: International Journal of Molecular Sciences, Vol 25, Iss 18, p 10080 (2024)

Excessive production and response to Type I interferons (IFNs) is a hallmark of systemic lupus erythematosus (SLE). Neuropsychiatric lupus (NPSLE) is a common manifestation of human SLE, with major depression as the most common presentation. Clinical

Externí odkaz: https://doaj.org/article/1d7df03da4054bb7a28f84e2815fceb6

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Akademický článek

Modulation of the Blood–Brain Barrier by Sigma-1R Activation

Autor: Eugen Brailoiu, Jeffrey L. Barr, Hailey N. Wittorf, Saadet Inan, Ellen M. Unterwald, Gabriela Cristina Brailoiu

Publikováno v: International Journal of Molecular Sciences, Vol 25, Iss 10, p 5147 (2024)

Sigma non-opioid intracellular receptor 1 (Sigma-1R) is an intracellular chaperone protein residing on the endoplasmic reticulum at the mitochondrial-associated membrane (MAM) region. Sigma-1R is abundant in the brain and is involved in several physi

Externí odkaz: https://doaj.org/article/6e67c20fcdc94615a26abde6b8ee839b

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Akademický článek

Reactivation of cocaine contextual memory engages mechanistic target of rapamycin/S6 kinase 1 signaling

Autor: Xiangdang Shi, Eva von Weltin, Emma Fitzsimmons, Chau Do, Carolina Caban Rivera, Chongguang Chen, Lee-Yuan Liu-Chen, Ellen M. Unterwald

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

Mechanistic target of rapamycin (mTOR) C1 and its downstream effectors have been implicated in synaptic plasticity and memory. Our prior work demonstrated that reactivation of cocaine memory engages a signaling pathway consisting of Akt, glycogen syn

Externí odkaz: https://doaj.org/article/9ce6582218524563975336a5db5daf95

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Akademický článek

CalDAG-GEFI mediates striatal cholinergic modulation of dendritic excitability, synaptic plasticity and psychomotor behaviors

Publikováno v: Neurobiology of Disease, Vol 158, Iss , Pp 105473- (2021)

CalDAG-GEFI (CDGI) is a protein highly enriched in the striatum, particularly in the principal spiny projection neurons (SPNs). CDGI is strongly down-regulated in two hyperkinetic conditions related to striatal dysfunction: Huntington's disease and l

Externí odkaz: https://doaj.org/article/dcb665d27eb248cbbbad7e35d7e418a7

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Akademický článek

Sex differences in the effect of the FKBP5 inhibitor SAFit2 on anxiety and stress-induced reinstatement following cocaine self-administration

Autor: Krista L. Connelly, Cassandra C. Wolsh, Jeffrey L. Barr, Michael Bauder, Felix Hausch, Ellen M. Unterwald

Publikováno v: Neurobiology of Stress, Vol 13, Iss , Pp 100232- (2020)

Cocaine use and withdrawal prompt stress system responses. Stress and the negative affective state produced by cocaine withdrawal are major triggers for relapse. FKBP5 is a co-chaperone of the glucocorticoid receptor and regulates HPA axis negative f

Externí odkaz: https://doaj.org/article/1d0076230ed842148452666ea9705dc3

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