Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Ellen Langille"'
Autor:
YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 6, Pp 719-740 (2024)
Abstract Tumor suppressor p53 (TP53) is frequently mutated in cancer, often resulting not only in loss of its tumor-suppressive function but also acquisition of dominant-negative and even oncogenic gain-of-function traits. While wild-type p53 levels
Externí odkaz:
https://doaj.org/article/4644b709c6d143dfb92c748768749b96
Autor:
Daniel Schramek, Geoffrey M. Wahl, Miguel Angel Pujana, Erik S. Knudsen, Agnieszka K. Witkiewicz, Michael D. Wilson, Hartland W. Jackson, Jeffrey L. Wrana, Therese Sørlie, David W. Cescon, Sean E. Egan, Gary D. Bader, Rod Bremner, Sampath K. Loganathan, Seda Barutcu, Thomas Nguyen, Jeff C. Liu, Masahiro Narimatsu, Daniel Trcka, Katelyn J. Kozma, Robin H. Oh, YiQing Lü, Andrew Elia, Sana Alvi, Ricky Tsai, Somaieh Afiuni-Zadeh, Samah El Ghamrasni, Helga Bergholtz, Ahmad Malik, Katie Teng, Roderic Espin, Liis Uuskula-Reimand, Minggao Liang, Zhibo Ma, Khalid N. Al-Zahrani, Ellen Langille
Systematically investigating the scores of genes mutated in cancer and discerning disease drivers from inconsequential bystanders is a prerequisite for precision medicine but remains challenging. Here, we developed a somatic CRISPR/Cas9 mutagenesis s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f3e88720028d1c1acd19d4e081944a9
https://doi.org/10.1158/2159-8290.c.6549708.v1
https://doi.org/10.1158/2159-8290.c.6549708.v1
Autor:
Daniel Schramek, Geoffrey M. Wahl, Miguel Angel Pujana, Erik S. Knudsen, Agnieszka K. Witkiewicz, Michael D. Wilson, Hartland W. Jackson, Jeffrey L. Wrana, Therese Sørlie, David W. Cescon, Sean E. Egan, Gary D. Bader, Rod Bremner, Sampath K. Loganathan, Seda Barutcu, Thomas Nguyen, Jeff C. Liu, Masahiro Narimatsu, Daniel Trcka, Katelyn J. Kozma, Robin H. Oh, YiQing Lü, Andrew Elia, Sana Alvi, Ricky Tsai, Somaieh Afiuni-Zadeh, Samah El Ghamrasni, Helga Bergholtz, Ahmad Malik, Katie Teng, Roderic Espin, Liis Uuskula-Reimand, Minggao Liang, Zhibo Ma, Khalid N. Al-Zahrani, Ellen Langille
Supplementary Data from Loss of Epigenetic Regulation Disrupts Lineage Integrity, Induces Aberrant Alveogenesis, and Promotes Breast Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a0b4da81cbb00416f796f44e9fdd2b9
https://doi.org/10.1158/2159-8290.22541622.v1
https://doi.org/10.1158/2159-8290.22541622.v1
Autor:
Yiqing Lu, Tiffany Cho, Saptaparna Mukherjee, Ahmad Ammar Malik, Nicolas Gonzalez-Foutel, Carmen Florencia Suarez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid Al-Zahrani, Zhen-Yuan Lin, Ricky Tsai, Varda Rotter, Patricia Ashton-Prolla, Lucia Beatriz Chemes, Jason Moffat, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3eb02d2c95bbcfd46a530189d82d5922
https://doi.org/10.15252/rc.2022665859
https://doi.org/10.15252/rc.2022665859
Autor:
YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Ahmad Malik, Nicolas S. Gonzalez-Foutel, Carmen Florencia Suarez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N. Al-Zahrani, Zhen Yuan Lin, Ricky Tsai, Varda Rotter, Patricia Ashton-Prolla, Lucia B. Chemes, Jason Moffat, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek
Tumour suppressor p53 (TP53) is the most frequently mutated gene in cancer. Several hotspot p53 mutants not only lose tumour suppressive capabilities, but also function in a dominant-negative manner, suppressing canonical wild-type p53 function. Furt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15b71a8a4725ba188f570cfb1571bcd4
https://doi.org/10.1101/2022.03.13.483372
https://doi.org/10.1101/2022.03.13.483372
Autor:
Zhibo Ma, Ricky Tsai, Miquel Angel Pujana, Geoffrey M. Wahl, Seda Barutcu, Sampath Kumar Loganathan, Katelyn. J. Kozma, Roderic Espín, Rod Bremner, Dan Trcka, Ellen Langille, Daniel Schramek, Ahmad Malik, Thomas Nguyen, Jeff C. Liu, Sean E. Egan, Katie Teng, Erik S. Knudsen, Gary D. Bader, Jeff Wrana, Hartland W. Jackson, Khalid N Al-Zahrani
Systematically investigating the scores of genes mutated in cancer and discerning real drivers from inconsequential bystanders is a prerequisite for Precision Medicine, but remains challenging. Here, we developed a somatic CRISPR/Cas9 mutagenesis scr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26ac8b66e265f67391d390be78544478
https://doi.org/10.1101/2021.10.22.465428
https://doi.org/10.1101/2021.10.22.465428
Autor:
Ellen Langille, Khalid N. Al-Zahrani, Zhibo Ma, Minggao Liang, Liis Uuskula-Reimand, Roderic Espin, Katie Teng, Ahmad Malik, Helga Bergholtz, Samah El Ghamrasni, Somaieh Afiuni-Zadeh, Ricky Tsai, Sana Alvi, Andrew Elia, YiQing Lü, Robin H. Oh, Katelyn J. Kozma, Daniel Trcka, Masahiro Narimatsu, Jeff C. Liu, Thomas Nguyen, Seda Barutcu, Sampath K. Loganathan, Rod Bremner, Gary D. Bader, Sean E. Egan, David W. Cescon, Therese Sørlie, Jeffrey L. Wrana, Hartland W. Jackson, Michael D. Wilson, Agnieszka K. Witkiewicz, Erik S. Knudsen, Miguel Angel Pujana, Geoffrey M. Wahl, Daniel Schramek
Publikováno v:
Cancer Discov
Systematically investigating the scores of genes mutated in cancer and discerning disease drivers from inconsequential bystanders is a prerequisite for precision medicine but remains challenging. Here, we developed a somatic CRISPR/Cas9 mutagenesis s
Publikováno v:
Cancer Research. 80:P1-03
In breast cancer, genome sequencing of patient have identified hundreds of genetic mutations associated with cancer, but which of these mutations drive tumor formation and which are simply bystanders is largely unknown. This is especially true for mu
In Vivo CRISPR/Cas9 Screening to Simultaneously Evaluate Gene Function in Mouse Skin and Oral Cavity
Publikováno v:
Journal of Visualized Experiments.
Genetically modified mouse models (GEMM) have been instrumental in assessing gene function, modeling human diseases, and serving as preclinical model to assess therapeutic avenues. However, their time-, labor- and cost-intensive nature limits their u
Autor:
Ellen Langille, Tao Yu, Erik S. Knudsen, Arthur Aubry, Agnieszka K. Witkiewicz, Kathryn A. Wikenheiser-Brokamp, Sean R. McCurdy, Nagako Akeno, Helen Dimaras, Jeffrey L. Wrana, Marek Pacal, Philippe P. Monnier, Kristine M. Wadosky, Benjamin H. Lok, Katherine Huang, Daniel Schramek, Mohammad E. Ahmad, Letian Zhang, David W. Goodrich, Rod Bremner, Alex Gregorieff, Susan P.C. Cole, Suying Lu, Tao Wang, Ming-Sound Tsao, Joel Pearson
Publikováno v:
Cancer Cell
Cancer heterogeneity impacts therapeutic response, driving efforts to discover over-arching rules that supersede variability. Here, we define pan-cancer binary classes based on distinct expression of YAP and YAP-responsive adhesion regulators. Combin