Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Ellen L. Mercado"'
Autor:
Simon Mitchell, Ellen L. Mercado, Adewunmi Adelaja, Jessica Q. Ho, Quen J. Cheng, Gourisankar Ghosh, Alexander Hoffmann
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Nuclear factor kappa B (NFκB) is a transcription factor that controls inflammation and cell survival. In clinical histology, elevated NFκB activity is a hallmark of poor prognosis in inflammatory disease and cancer, and may be the result of a combi
Externí odkaz:
https://doaj.org/article/e2c67ada706044d395a370f9036e98b5
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e45078 (2012)
NF-κB, a transcription factor, becomes activated during the Unfolded Protein Response (UPR), an endoplasmic reticulum (ER) stress response pathway. NF-κB is normally held inactive by its inhibitor, IκBα. Multiple cellular pathways activate IKK (I
Externí odkaz:
https://doaj.org/article/280dba229211443d82c3c5b0f8f3ba81
Autor:
Frank McCormick, Anatoly Urisman, Kathy H. Li, Jacqueline Galeas, Pau Castel, Jillian M. Silva, Evan Markegard, Ellen L. Mercado
Publikováno v:
Cancer Research. 78:5520-5520
Spred proteins negatively regulate Ras/MAPK signaling following growth factor stimulation. Inhibition of Ras primary occurs through Spreds ability to bind and localize NF1, a RasGAP and major tumor suppressor, to the plasma membrane. Spred1 and NF1 l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c24418224eb5e3a2f1d4aadca47ac7cb
https://doi.org/10.1158/1538-7445.am2018-5520
https://doi.org/10.1158/1538-7445.am2018-5520
Autor:
Anatoly Urisman, Frank McCormick, Jacqueline Galeas, Evan Markegard, Jillian M. Silva, Marena I. Trinidad, Ellen L. Mercado
Publikováno v:
Cancer Research. 77:1370-1370
Spred proteins negatively regulate Ras/MAPK signaling following growth factor stimulation. Inhibition of Ras primary occurs through Spreds ability to bind and localize NF1, a RasGAP and major tumor suppressor, to the plasma membrane. Spred1 and NF1 l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::006c99009ef176ddb83b223d6a03cc10
https://doi.org/10.1158/1538-7445.am2017-1370
https://doi.org/10.1158/1538-7445.am2017-1370
Autor:
Jacqueline Galeas, Anatoly Urisman, Frank McCormick, Ellen L. Mercado, Evan Markegard, Marena I. Trinidad
Publikováno v:
Cancer Research. 76:1874-1874
Spred proteins negatively regulate Ras/MAPK signaling following mitogen stimulation. Inhibition of Ras primary occurs through Spreds ability to bind and localize NF1, a RasGAP and major tumor suppressor, to the plasma membrane. Loss-of-function Spred
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c46da0c8748666a4e2094b88bdba0951
https://doi.org/10.1158/1538-7445.am2016-1874
https://doi.org/10.1158/1538-7445.am2016-1874
A shared molecular mechanism underlies the human rasopathies Legius syndrome and Neurofibromatosis-1
Autor:
Hilda Hernandez, Juan A. Oses-Prieto, Alma L. Burlingame, Ellen L. Mercado, Erika L. Bell, Frank McCormick, Timothy R. Stowe, Irma B. Stowe
Publikováno v:
Genes & development, vol 26, iss 13
The Ras/mitogen-activated protein kinase (MAPK) pathway plays a critical role in transducing mitogenic signals from receptor tyrosine kinases. Loss-of-function mutations in one feedback regulator of Ras/MAPK signaling, SPRED1 (Sprouty-related protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4f0e1f5aaa64f18f79887fbbca02963
https://escholarship.org/uc/item/7t828278
https://escholarship.org/uc/item/7t828278
Publikováno v:
PloS one, vol 7, iss 10
PLoS ONE, Vol 7, Iss 10, p e45078 (2012)
PLoS ONE
PLoS ONE, Vol 7, Iss 10, p e45078 (2012)
PLoS ONE
NF-κB, a transcription factor, becomes activated during the Unfolded Protein Response (UPR), an endoplasmic reticulum (ER) stress response pathway. NF-κB is normally held inactive by its inhibitor, IκBα. Multiple cellular pathways activate IKK (I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::738f98c4c9f30a7854f0632922055219
https://escholarship.org/uc/item/16q657wm
https://escholarship.org/uc/item/16q657wm
Publikováno v:
Cancer Research. 72:LB-151
The Ras/Mitogen Activated Protein Kinase (MAPK) plays a critical role in cell signaling downstream of receptor tyrosine kinases. The conserved Sprouty family proteins function as feedback regulators of Ras/MAPK signaling. Loss of function mutations i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::051082710fbb2eb26878beb44446c7b2
https://doi.org/10.1158/1538-7445.am2012-lb-151
https://doi.org/10.1158/1538-7445.am2012-lb-151