Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Ellen Kraig"'
Autor:
Mitzi M. Gonzales, Valentina R. Garbarino, Erin Pollet, Juan P. Palavicini, Dean L. Kellogg Jr., Ellen Kraig, Miranda E. Orr
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 10 (2022)
Alzheimer’s disease and related dementias (ADRD) are among the top contributors to disability and mortality in later life. As with many chronic conditions, aging is the single most influential factor in the development of ADRD. Even among older adu
Externí odkaz:
https://doaj.org/article/0beaf9a2d16a4e038cddae96ddea033e
Autor:
Rohina Rubicz, Robert Yolken, Eugene Drigalenko, Melanie A Carless, Thomas D Dyer, Lara Bauman, Phillip E Melton, Jack W Kent, John B Harley, Joanne E Curran, Matthew P Johnson, Shelley A Cole, Laura Almasy, Eric K Moses, Nikhil V Dhurandhar, Ellen Kraig, John Blangero, Charles T Leach, Harald H H Göring
Publikováno v:
PLoS Genetics, Vol 9, Iss 1, p e1003147 (2013)
Infection with Epstein-Barr virus (EBV) is highly prevalent worldwide, and it has been associated with infectious mononucleosis and severe diseases including Burkitt lymphoma, Hodgkin lymphoma, nasopharyngeal lymphoma, and lymphoproliferative disorde
Externí odkaz:
https://doaj.org/article/ad6098094c2d4c95816c9e8dc7f7c082
Autor:
Allison K. Hester, Manpreet K. Semwal, Sergio Cepeda, Yangming Xiao, Meghan Rueda, Kymberly Wimberly, Thomas Venables, Thamotharampillai Dileepan, Ellen Kraig, Ann V. Griffith
Publikováno v:
Cell Reports. 38:110363
Thymic atrophy reduces naive T cell production and contributes to increased susceptibility to viral infection with age. Expression of tissue-restricted antigen (TRA) genes also declines with age and has been thought to increase autoimmune disease sus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4e80d628b7ae98040406bf4c75cf1be
https://doi.org/10.1016/j.celrep.2022.110363
https://doi.org/10.1016/j.celrep.2022.110363
Autor:
Yubo Wu, Hanyu Liang, Terry Q. Romo, Nicolas Musi, Adriana D. Benavides, Tyler J. Curiel, Dean L. Kellogg, Wouter Koek, Jonathan Gelfond, Ellen Kraig, Martin A. Javors, Leslie A. Linehan, Laura K. Chiodo, Qianqian Liu
Publikováno v:
Experimental Gerontology. 105:53-69
Inhibition of the mechanistic target of rapamycin (mTOR) pathway by rapamycin (RAPA), an FDA-approved immunosuppressive drug used as a clinical therapy to prevent solid organ allograft rejection, enhances longevity in mice. Importantly, RAPA was effi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25b477917408ff69ea452550d6acd739
https://doi.org/10.1016/j.exger.2017.12.026
https://doi.org/10.1016/j.exger.2017.12.026
Publikováno v:
The Journal of Immunology. 206:98.36-98.36
Susceptibility to many autoimmune diseases increases with age, but the mechanisms linking aging and autoimmunity remain incompletely understood. One hallmark of the aging immune system is atrophy of the thymus, the primary site of T lymphocyte genera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25560b599b964398f3004e6739d20edc
https://doi.org/10.4049/jimmunol.206.supp.98.36
https://doi.org/10.4049/jimmunol.206.supp.98.36
Publikováno v:
The Journal of Immunology. 204:143.2-143.2
Susceptibility to many autoimmune diseases increases with age, however, mechanisms linking aging and susceptibility to autoimmunity remain incompletely understood. One hallmark of the aging immune system is atrophy of the thymus, the primary site of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84f170d3f9befb1a7fdd0ea1aafe0c2d
https://doi.org/10.4049/jimmunol.204.supp.143.2
https://doi.org/10.4049/jimmunol.204.supp.143.2
Autor:
Ellen Kraig, Matthew P. Johnson, Rohina Rubicz, Laura Almasy, Melanie A. Carless, Shelley A. Cole, Eric K. Moses, Jack W. Kent, Rector Arya, Harald H H Göring, Robert H. Yolken, Thomas D. Dyer, Sharon P. Fowler, John Blangero, Joanne E. Curran, Charles T. Leach, Ravindranath Duggirala, Sobha Puppala, Eugene Drigalenko
Publikováno v:
European Journal of Human Genetics. 23:1544-1548
Populations and individuals differ in susceptibility to infections because of a number of factors, including host genetic variation. We previously demonstrated that differences in antibody titer, which reflect infection history, are significantly her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd1aa1215af37bee787d024d816c9bec
https://doi.org/10.1038/ejhg.2015.24
https://doi.org/10.1038/ejhg.2015.24
Autor:
Randy Strong, Arlan Richardson, Salvatore Oddo, Martin A. Javors, Ellen Kraig, Adriana D. Benavides, David X. Medina, Smita Majumder, Antonella Caccamo
Publikováno v:
Aging Cell. 11:326-335
Understanding the factors that contribute to age-related cognitive decline is imperative, particularly as age is the major risk factor for several neurodegenerative disorders. Levels of several cytokines increase in the brain during aging, including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81d289eb33e1cd86c0df450624b7aeb0
https://doi.org/10.1111/j.1474-9726.2011.00791.x
https://doi.org/10.1111/j.1474-9726.2011.00791.x
Autor:
Earlanda Williams, Amanda Pasquali, Anthony J. Infante, Nathan E. Standifer, Sue Stacy, Ellen Kraig, Keith A. Krolick
Publikováno v:
The Journal of Immunology. 184:6067-6075
Age-related changes in immune regulation are likely to account for the age-associated increase in serum autoantibody levels and in certain autoimmune disorders, such as myasthenia gravis (MG). To demonstrate directly a loss of immune tolerance in old
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6341b8a337d44eae2c015fbd12635fd2
https://doi.org/10.4049/jimmunol.0901618
https://doi.org/10.4049/jimmunol.0901618
Publikováno v:
The Journal of Immunology. 200:167.8-167.8
The human MHC class II molecules HLA-DR2b (DRB1*1501) and HLA-DR4 (DRB1*0401) are strongly linked to increased susceptibility to autoimmune diseases, such as multiple sclerosis (MS) and rheumatoid arthritis (RA). However, their contribution to diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fbaaf27f4ebfd42c5fcdafdc067dd17
https://doi.org/10.4049/jimmunol.200.supp.167.8
https://doi.org/10.4049/jimmunol.200.supp.167.8