Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Ellen Koepf"'
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 128:200-209
The tendency of protein pharmaceuticals to form aggregates is a major challenge during formulation development, as aggregation affects quality and safety of the product. In particular, the formation of large native-like particles in the context of li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58cfba2a9d0865c2e2c77e43bc71c52d
https://doi.org/10.1016/j.ejpb.2018.04.024
https://doi.org/10.1016/j.ejpb.2018.04.024
Autor:
Wolfgang Friess, Bjoern Braunschweig, Rudolf Schroeder, Manuela E Richert, Gerald Brezesinski, Ellen Koepf
Publikováno v:
International Journal of Pharmaceutics. 541:234-245
Both, formulation parameters and the presence of liquid-air interfaces are known to affect the aggregation of protein drugs. In this study, the impact of pH on the liquid-air interfacial behavior of three proteins, a polyclonal and two monoclonal ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbaefc7aac7343282b666d3de81477e6
https://doi.org/10.1016/j.ijpharm.2018.02.009
https://doi.org/10.1016/j.ijpharm.2018.02.009
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 119:396-407
The presence of liquid-air interfaces in protein pharmaceuticals is known to negatively impact product stability. Nevertheless, the mechanisms behind interface-related protein aggregation are not yet fully understood. Little is known about the physic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a0947a6437d78fb14477ab76d9b40a8
https://doi.org/10.1016/j.ejpb.2017.07.006
https://doi.org/10.1016/j.ejpb.2017.07.006
Autor:
Dean C. Ripple, Karoline Bechtold-Peters, Rukman De Silva, E. Neil Lewis, Anja Matter, Olga Laskina, Linda O. Narhi, Roman Mathaes, Richard E. Cavicchi, John F. Carpenter, Sophia Kenrick, Ellen Koepf, Andrea Hawe, Sambit R. Kar
Publikováno v:
The AAPS journal. 22(1)
The phase-appropriate application of analytical methods to characterize, monitor, and control particles is an important aspect of the development of safe and efficacious biotherapeutics. The AAPS Product Attribute and Biological Consequences (PABC) f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31444524f4cde3ec5c4bd5ecd8ec1684
https://pubmed.ncbi.nlm.nih.gov/31677011
https://pubmed.ncbi.nlm.nih.gov/31677011
Publikováno v:
International Journal of Multiphysics, Vol 13, Iss 1 (2019)
The formation of Faraday waves in a liquid inside a cylindrical vessel under the influence of vertical vibration is studied. The stability thresholds and its mode decomposition are obtained using a linear stability analysis. The stability model is va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0256a85d75ca5efe79503973d90d48cb
https://doi.org/10.21152/1750-9548.13.1.61
https://doi.org/10.21152/1750-9548.13.1.61
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 128
The tendency of protein pharmaceuticals to form aggregates is a major challenge during formulation development, as aggregation affects quality and safety of the product. In particular, the formation of large native-like particles in the context of li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6a50afb2afabbaeec531f4e46c993b70
https://pubmed.ncbi.nlm.nih.gov/29723667
https://pubmed.ncbi.nlm.nih.gov/29723667