Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Ellen Knuepfer"'
Autor:
Rameswara R. Segireddy, Hugo Belda, Annie S. P. Yang, Kirsten Dundas, Julia Knoeckel, Francis Galaway, Laura Wood, Doris Quinkert, Ellen Knuepfer, Moritz Treeck, Gavin J. Wright, Alexander D. Douglas
Publikováno v:
Malaria Journal, Vol 23, Iss 1, Pp 1-19 (2024)
Abstract Background Sporozoite invasion of hepatocytes is an essential step in the Plasmodium life-cycle and has similarities, at the cellular level, to merozoite invasion of erythrocytes. In the case of the Plasmodium blood-stage, efforts to identif
Externí odkaz:
https://doaj.org/article/cd30976dbd8d4667bc3b6da3dc678722
Autor:
Melissa N. Hart, Franziska Mohring, Sophia M. DonVito, James A. Thomas, Nicole Muller-Sienerth, Gavin J. Wright, Ellen Knuepfer, Helen R. Saibil, Robert W. Moon
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Invasion of red blood cells (RBCs) by Plasmodium merozoites is critical to their continued survival within the host. Two major protein families, the Duffy binding-like proteins (DBPs/EBAs) and the reticulocyte binding like proteins (RBLs/RHs
Externí odkaz:
https://doaj.org/article/c48e41643e4c4f30a28ba70dc114bca3
Autor:
Tanyaluck Kampoun, Somdet Srichairatanakool, Parichat Prommana, Philip J. Shaw, Judith L. Green, Ellen Knuepfer, Anthony A. Holder, Chairat Uthaipibull
Publikováno v:
Malaria Journal, Vol 21, Iss 1, Pp 1-10 (2022)
Abstract Background The resistance of Plasmodium falciparum to artemisinin-based (ART) drugs, the front-line drug family used in artemisinin-based combination therapy (ACT) for treatment of malaria, is of great concern. Mutations in the kelch13 (k13)
Externí odkaz:
https://doaj.org/article/3196b35f1366420a955e8f0b0687d746
Autor:
Angela Holder, Jeannine Kolakowski, Chloe Rosentreter, Ellen Knuepfer, Sabine A. F. Jégouzo, Oliver Rosenwasser, Heather Harris, Lotta Baumgaertel, Amanda Gibson, Dirk Werling
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Innate immune receptors that form complexes with secondary receptors, activating multiple signalling pathways, modulate cellular activation and play essential roles in regulating homeostasis and immunity. We have previously identified a variety of bo
Externí odkaz:
https://doaj.org/article/6c8a0461c0404ac38b0aa2331023ccb8
Autor:
Supawadee Maneekesorn, Ellen Knuepfer, Judith L. Green, Parichat Prommana, Chairat Uthaipibull, Somdet Srichairatanakool, Anthony A. Holder
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract The inducible Di-Cre system was used to delete the putative ubiquitin-conjugating enzyme 13 gene (ubc13) of Plasmodium falciparum to study its role in ubiquitylation and the functional consequence during the parasite asexual blood stage. Del
Externí odkaz:
https://doaj.org/article/056390903119464d8e684ecde45b5954
Autor:
Vanndita Bahl, Kritika Chaddha, Syed Yusuf Mian, Anthony A. Holder, Ellen Knuepfer, Deepak Gaur
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Plasmodium falciparum, the parasite responsible for severe malaria, develops within erythrocytes. Merozoite invasion and subsequent egress of intraerythrocytic parasites are essential for this erythrocytic cycle, parasite survival and pathog
Externí odkaz:
https://doaj.org/article/f65dafb8736d4e99a8c5c3989531a5ab
Autor:
Anja C. Schlott, Ellen Knuepfer, Judith L. Green, Philip Hobson, Aaron J. Borg, Julia Morales-Sanfrutos, Abigail J. Perrin, Catherine Maclachlan, Lucy M. Collinson, Ambrosius P. Snijders, Edward W. Tate, Anthony A. Holder
Publikováno v:
PLoS Biology, Vol 19, Iss 10 (2021)
We have combined chemical biology and genetic modification approaches to investigate the importance of protein myristoylation in the human malaria parasite, Plasmodium falciparum. Parasite treatment during schizogony in the last 10 to 15 hours of the
Externí odkaz:
https://doaj.org/article/5fbf8e9a9f734a64b495f33819b59ac8
Autor:
Emma S Sherling, Abigail J Perrin, Ellen Knuepfer, Matthew R G Russell, Lucy M Collinson, Louis H Miller, Michael J Blackman
Publikováno v:
PLoS Pathogens, Vol 15, Iss 9, p e1008049 (2019)
The malaria parasite Plasmodium falciparum invades, replicates within and destroys red blood cells in an asexual blood stage life cycle that is responsible for clinical disease and crucial for parasite propagation. Invasive malaria merozoites possess
Externí odkaz:
https://doaj.org/article/2489d6a65cf34f7da3cb255cdebd8f41
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Successful establishment of CRISPR/Cas9 genome editing technology in Plasmodium spp. has provided a powerful tool to transform Plasmodium falciparum into a genetically more tractable organism. Conditional gene regulation approaches are requi
Externí odkaz:
https://doaj.org/article/d5e83861321b4d35ab33c4b412310346
Divergent roles for the RH5 complex components, CyRPA and RIPR in human-infective malaria parasites.
Autor:
Ellen Knuepfer, Katherine E Wright, Surendra Kumar Prajapati, Thomas A Rawlinson, Franziska Mohring, Marion Koch, Oliver R Lyth, Steven A Howell, Elizabeth Villasis, Ambrosius P Snijders, Robert W Moon, Simon J Draper, Anna Rosanas-Urgell, Matthew K Higgins, Jake Baum, Anthony A Holder
Publikováno v:
PLoS Pathogens, Vol 15, Iss 6, p e1007809 (2019)
Malaria is caused by Plasmodium parasites, which invade and replicate in erythrocytes. For Plasmodium falciparum, the major cause of severe malaria in humans, a heterotrimeric complex comprised of the secreted parasite proteins, PfCyRPA, PfRIPR and P
Externí odkaz:
https://doaj.org/article/bf3f93b27c2446d885488d06fde5f031