Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Ellen K. Kick"'
Autor:
Ricardo A. García, PhD, Bruce R. Ito, PhD, John A. Lupisella, MSc, Nancy A. Carson, BSc, Mei-Yin Hsu, MSc, Gayani Fernando, MSc, Madeleine Heroux, PhD, Michel Bouvier, PhD, Elizabeth Dierks, PhD, Ellen K. Kick, PhD, David A. Gordon, PhD, Jian Chen, PhD, Gabe Mintier, BSc, Marilyn Carrier, PhD, Stéphane St-Onge, MSc, Himanshu Shah, MSc, Jordan Towne, BSc, Marcela Sotelo Bucardo, BSc, Xiuying Ma, PhD, Carol S. Ryan, BSc, Nicholas R. Wurtz, PhD, Jacek Ostrowski, PhD, Francisco J. Villarreal, MD, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 4, Iss 8, Pp 905-920 (2019)
Summary: Dysregulated inflammation following myocardial infarction (MI) promotes left ventricular (LV) remodeling and loss of function. Targeting inflammation resolution by activating formyl peptide receptors (FPRs) may limit adverse remodeling and p
Externí odkaz:
https://doaj.org/article/87187fce26ae464386af76218484bf38
Autor:
Nicholas R. Wurtz, James A. Johnson, Andrew Viet, Pravin S. Shirude, Vishweshwaraiah Baligar, Sudhakara Madduri, Daniel L. Cheney, Hyunsoo Park, John A. Lupisella, Mei-Yin Hsu, Mojgan Abousleiman, Michael A. Galella, Darpandeep Aulakh, Elizabeth A. Dierks, Ricardo A. Garcia, Jacek Ostrowski, Ellen K. Kick, Ruth R. Wexler
Publikováno v:
ACS Med Chem Lett
[Image: see text] Formyl peptide receptor 2 (FPR2) agonists have shown efficacy in inflammatory-driven animal disease models and have the potential to treat a range of diseases. Many reported synthetic agonists contain a phenylurea, which appears to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a365e85b2833ea7dfaf2477aac5a41a
https://doi.org/10.1021/acsmedchemlett.2c00079
https://doi.org/10.1021/acsmedchemlett.2c00079
Publikováno v:
Burger's Medicinal Chemistry and Drug Discovery
This chapter will be focused on recent advances in the medicinal chemistry of agonist, antagonist, and modulator ligands of selected nuclear hormone receptors (NHRs) that are of special interest in the metabolic diseases therapeutic area (diabetes, o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5441a910873ea23a96dbcae033ce738
https://doi.org/10.1002/0471266949.bmc191.pub2
https://doi.org/10.1002/0471266949.bmc191.pub2
Autor:
John Lupisella, Stéphane St-Onge, Marilyn Carrier, Erica M. Cook, Tao Wang, Chi Sum, Gayani Fernando, Kendra Apgar, Rongan Zhang, Nancy Carson, Bradley J. Snyder, Carol S. Ryan, Xiuying Ma, Elizabeth A. Dierks, Sean Little, Ellen K. Kick, Nicholas R. Wurtz, Michel Bouvier, Madeleine Héroux, Ricardo A. Garcia
Publikováno v:
ACS pharmacologytranslational science. 5(10)
Formyl peptide receptor 2 (FPR2) plays an integral role in the transition of macrophages from a pro-inflammatory program to one that is pro-resolving. FPR2-mediated stimulation of resolution post myocardial infarction has demonstrated efficacy in rod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2b88f9437b178647894ccc435a7eb5d
https://pubmed.ncbi.nlm.nih.gov/36268126
https://pubmed.ncbi.nlm.nih.gov/36268126
Autor:
Stéphane St-Onge, Bruce R. Ito, John A. Lupisella, Madeleine Héroux, Ricardo Garcia, Marilyn Carrier, Mei-Yin Hsu, Carol S. Ryan, Michel Bouvier, Elizabeth A. Dierks, Nicholas R. Wurtz, Ellen K. Kick, Jian Chen, Nancy A. Carson, Gayani Fernando, Jordan Kelly Towne, Jacek Ostrowski, Francisco Villarreal, Himanshu Shah, Xiuying Ma, Marcela Sotelo Bucardo, Gabe Mintier, David A. Gordon
Publikováno v:
JACC: Basic to Translational Science, Vol 4, Iss 8, Pp 905-920 (2019)
Summary: Dysregulated inflammation following myocardial infarction (MI) promotes left ventricular (LV) remodeling and loss of function. Targeting inflammation resolution by activating formyl peptide receptors (FPRs) may limit adverse remodeling and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c03af88d759da1d54a687d698b9a270
http://www.sciencedirect.com/science/article/pii/S2452302X19301962
http://www.sciencedirect.com/science/article/pii/S2452302X19301962
Autor:
Moises Muratt Bustamante-Pozo, Rongan Zhang, Nancy L. Carson, Madeleine Héroux, Michel Bouvier, Jian Chen, David A. Gordon, Bruce R. Ito, Stéphane St.-Onge, Gayani Fernando, Marilyn Carrier, Francisco Villarreal, Zhaoqing Wang, Alejandra Garate-Carrillo, Carol S. Ryan, Jignesh Nagar, Jacek Ostrowski, John A. Lupisella, Ricardo Garcia, Shailesh Dudhgaonkar, Debra Search, Ellen K. Kick, Xiuying Ma, Ruth R. Wexler, Mei-Yin Hsu, Elizabeth A. Dierks, Nicholas R. Wurtz, John Allocco
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • MI leads to ischemic damage of myocardium and activation of inflammatory programs as part of the wound healing response. • Selective activation of FPR2 on macrophages potentiates key cellular activities that enab
Highlights • MI leads to ischemic damage of myocardium and activation of inflammatory programs as part of the wound healing response. • Selective activation of FPR2 on macrophages potentiates key cellular activities that enab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23e8893e04bab7931d672cda68a46242
https://pubmed.ncbi.nlm.nih.gov/34466754
https://pubmed.ncbi.nlm.nih.gov/34466754
Autor:
Javed Khan, Xiaoqin Liu, Sutjano Jusuf, Carol Hui Hu, Gregory A. Locke, Franck Duclos, Ruth R. Wexler, Gerald J. Duke, Joanne M. Smallheer, Ellen K. Kick, Meriah Neissel Valente, O. Scott Halpern
Publikováno v:
Bioorganicmedicinal chemistry letters. 42
Myeloperoxidase (MPO), a critical enzyme in antimicrobial host-defense, has been implicated in chronic inflammatory diseases such as coronary artery disease. The design and evaluation of MPO inhibitors for the treatment of cardiovascular disease are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a60d009ac35f0cf724f08285cd374dfa
https://pubmed.ncbi.nlm.nih.gov/33811992
https://pubmed.ncbi.nlm.nih.gov/33811992
Autor:
Arathi Krishnakumar, Lisa M. Kopcho, Michael Basso, Benjamin P. Vokits, Glenn H. Cantor, Sutjano Jusuf, Lei Zhao, Lynn M. Abell, Ashok Dongre, Javed Khan, Steven A. Spronk, Gregory A. Locke, Gerald J. Duke, Andrew Quoc Viet, Scott A. Shaw, Franck Duclos, Ellen K. Kick, Joelle M. Onorato, Charles G. Clark, Ruth R. Wexler, Dilger Andrew K, Ji Gao
Publikováno v:
Bioorganicmedicinal chemistry. 28(22)
Myeloperoxidase (MPO) is a heme peroxidase found in neutrophils, monocytes and macrophages that efficiently catalyzes the oxidation of endogenous chloride into hypochlorous acid for antimicrobial activity. Chronic MPO activation can lead to indiscrim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30388866645cc723c34668c20055fd32
https://pubmed.ncbi.nlm.nih.gov/33007547
https://pubmed.ncbi.nlm.nih.gov/33007547
Autor:
John A. Lupisella, Kiyoshi Fujii, David A. Gordon, Mei-Yin Hsu, Toshikazu Yamaoka, Yasuchi Kohno, Kohei Ohata, Kosuke Tsuda, Kazuto Arakawa, Nancy L. Carson, Kazunori Fukuchi, Ruth R. Wexler, Francisco Villarreal, Ellen K. Kick, Junichi Ishiyama, Jacek Ostrowski, Shingo Matsushima, Hitomi Yamada, Yoshifumi Saito, Bruce R. Ito, Yoshikazu Asahina, Ricardo Garcia, Nicholas R. Wurtz
Publikováno v:
Journal of medicinal chemistry. 63(17)
Formyl peptide receptor 2 (FPR2) agonists can stimulate resolution of inflammation and may have utility for treatment of diseases caused by chronic inflammation, including heart failure. We report the discovery of a potent and selective FPR2 agonist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae320f52a2002341eb02a49f914b8d9d
https://pubmed.ncbi.nlm.nih.gov/32407089
https://pubmed.ncbi.nlm.nih.gov/32407089
Autor:
Lisa Salvador, Richard Martin, Raju Mohan, Philip Wastall, Zhaoqing Wang, John A. Lupisella, Kamelia Behnia, Paul G. Sleph, Todd G. Kirchgessner, Petia Shipkova, Gayani Fernando, Jane Zhang, Carol S. Ryan, Rongan Zhang, Shuyan Du, Tong Li, Harold Malone, Ellen K. Kick, Glenn H. Cantor, Jun Zhu, Yu Chen Barrett, Jacek Ostrowski, Long Yuan, Denise Grimm, Aiqing He, John S. Lee, Robert J.A. Frost, Mohit D. Gandhi, Ricardo Garcia, Robert J. Garmise, Xiaoqin Liu
Publikováno v:
Cell Metabolism. 24:223-233
The development of LXR agonists for the treatment of coronary artery disease has been challenged by undesirable properties in animal models. Here we show the effects of an LXR agonist on lipid and lipoprotein metabolism and neutrophils in human subje
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ab02b44e38f42df280821d0a942bc40
https://doi.org/10.1016/j.cmet.2016.07.016
https://doi.org/10.1016/j.cmet.2016.07.016