Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Ellen K. Bayne"'
Autor:
S. Matheravidathu, Q. Shao, Thomas Wisniewski, Mary Struthers, Larry Peterson, Paul A. Fischer, J. Flanagan, Michael J. Forrest, X. Song, R. Wnek, Julie A. DeMartino, Lihu Yang, Ellen K. Bayne
Publikováno v:
Journal of Immunological Methods. 352:101-110
Inhibition of monocyte and macrophage function by targeting chemokine receptors represents an attractive strategy for therapeutic intervention in inflammatory diseases. We describe an assay to assess chemokine receptor function on whole blood monocyt
Autor:
Michael J. Forrest, Larry Peterson, Ellen K. Bayne, John S. Mudgett, Julie A. DeMartino, D. Euan MacIntyre, Catherine Abbadie, Jill A. Lindia, Anne Marie Cumiskey
Publikováno v:
Proceedings of the National Academy of Sciences. 100:7947-7952
Mice lacking the chemokine receptor chemotactic cytokine receptor 2 (CCR2) have a marked attenuation of monocyte recruitment in response to various inflammatory stimuli and a reduction of inflammatory lesions in models of demyelinating disease. In th
Autor:
Ellen K. Bayne, Robin Poole, Wim B. van den Berg, Clark Billinghurst, John S. Mudgett, Pieter Buma, Peter L E M van Lent, Irwin I. Singer, Peter M. van der Kraan, A.E.M. Holthuysen, Reinout Stoop, Joyce B. J. van Meurs
Publikováno v:
Arthritis & Rheumatism. 42:2074-2084
Objective The destruction of articular cartilage during arthritis is due to proteolytic cleavage of the extracellular matrix components. This study investigates the kinetic involvement of metalloproteinases (MMPs) in the degradation of the 2 major ca
Autor:
B. Azzolina, Julia M. Ayala, B. Chang, M. Einstein, Diane Thiboutot, Richard A. Mumford, John G. Flanagan, Georgianna Harris, Irwin I. Singer, Ellen K. Bayne, David A. Whiting
Publikováno v:
British Journal of Dermatology. 141:481-491
The predominant form of 5alpha-reductase (5aR) in human scalp is 5aR1. None the less, clinical studies have shown that finasteride, a selective inhibitor of 5aR2, decreases scalp dihydrotestosterone and promotes hair growth in men with androgenetic a
Autor:
Joyce B. J. van Meurs, Wim B. van den Berg, Peter L E M van Lent, A.E.M. Holthuysen, Ellen K. Bayne, Irwin I. Singer
Publikováno v:
Arthritis & Rheumatism. 42:1128-1139
Objective Two major cleavage sites, one mediated by metalloproteinases (MMPs) and the other by an as-yet unidentified enzyme termed aggrecanase, have been observed in aggrecan. To learn more about the relative contribution of these enzymes during car
Autor:
Irwin I. Singer, Wim B. van den Berg, Fons A. J. van de Loo, Ellen K. Bayne, Joyce B. J. van Meurs, Peter L E M van Lent
Publikováno v:
Arthritis & Rheumatism. 41:647-656
Objective To investigate the relationship between occurrence of the matrix metalloproteinase-generated neoepitope VDIPEN and proteoglycan (PG) loss in arthritis, and to examine the role of interleukin-1 (IL-1) in VDIPEN expression. Methods VDIPEN exp
Autor:
Irwin I. Singer, John G. Flanagan, Nicole A. Chartrain, A. J. Forsyth, Howard Y. Chen, C. F. Shen, Ellen K. Bayne, Denise M. Visco, John S. Mudgett, Karla Stevens, Myrna E. Trumbauer, Douglas W. Kawka, Nancy I. Hutchinson, Joseph McDonnell
Publikováno v:
Arthritis & Rheumatism. 41:110-121
Objective It has long been proposed that stromelysin is one of the major degradative matrix metalloproteinases responsible for the loss of cartilage in rheumatoid arthritis (RA) and osteoarthritis (OA). This hypothesis was tested by examining the art
Autor:
Kevin T. Chapman, Jeffrey R. Weidner, Ellen K. Bayne, Jayne Chin, S Scott, Irwin I. Singer, Matthew J. Kostura, Douglas K. Miller, Guadalupe A. Limjuco
Publikováno v:
The Journal of Experimental Medicine
Interleukin-1 beta (IL-1 beta)-converting enzyme (ICE) is a novel cysteine protease that cleaves the 31-kD inactive cytoplasmic IL-1 beta precursor into active extracellular 17-kD IL-1 beta. The ICE gene product is a 45-kD proenzyme that requires pro
Autor:
Lawrence J. Bonassar, Kimberly A. Jeffries, Michael W. Lark, Kevin T. Chapman, Joseph Mcdonnell, William K. Hagmann, Julie Olszewski, Ellen K. Bayne, Eliot H. Frank, Alan J. Grodzinsky, Vernon L. Moore
Publikováno v:
Arthritis & Rheumatism. 38:1678-1686
Objective. To characterize the effects of intra-articular injection of recombinant human stromelysin (SLN) on the matrix composition and physical properties of cartilage from lapine stifle joints and the modulation of these effects by the systemic ad
Autor:
Susan Donatelli, Douglas W. Kawka, Richard A. Mumford, Hollis R. Williams, Jeffrey R. Weidner, Michael W. Lark, Julia M. Ayala, Irwin I. Singer, Ellen K. Bayne, Tibor T. Glant
Publikováno v:
Journal of Clinical Investigation. 95:2178-2186
The destruction of articular cartilage in immune inflammatory arthritic disease involves the proteolytic degradation of its extracellular matrix. The role of activated matrix metalloproteinases (MMPs) in the chondrodestructive process was studied by