Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Ellen J Hess"'
Autor:
Cecília N. Prudente, Randall Stilla, Shivangi Singh, Cathrin Buetefisch, Marian Evatt, Stewart Factor, Alan Freeman, Xiaoping Philip Hu, Ellen J Hess, K. Sathian, H. A. Jinnah
Publikováno v:
Frontiers in Neurology, Vol 7 (2016)
Cervical dystonia (CD) is a neurological disorder characterized by abnormal movements and postures of the head. The brain regions responsible for these abnormal movements are not well understood, because most imaging techniques for assessing regional
Externí odkaz:
https://doaj.org/article/eb6ca0caa7a04c5891e96f88c42bf57c
Spiny projection neurons exhibit transcriptional signatures within subregions of the dorsal striatum
Autor:
Kaitlyn M. Roman, Ashok R. Dinasarapu, Alison VanSchoiack, P. Martin Ross, David Kroeppler, H.A. Jinnah, Ellen J. Hess
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113435- (2023)
Summary: The dorsal striatum is organized into functional territories defined by corticostriatal inputs onto both direct and indirect spiny projection neurons (SPNs), the major cell types within the striatum. In addition to circuit connectivity, stri
Externí odkaz:
https://doaj.org/article/79c97a5da93d41fea8392ddb3074233f
Autor:
Diane J. Sutcliffe, Ashok R. Dinasarapu, Jasper E. Visser, Joery den Hoed, Fatemeh Seifar, Piyush Joshi, Irene Ceballos-Picot, Tejas Sardar, Ellen J. Hess, Yan V. Sun, Zhexing Wen, Michael E. Zwick, H. A. Jinnah
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Lesch-Nyhan disease (LND) is an inherited disorder caused by pathogenic variants in the HPRT1 gene, which encodes the purine recycling enzyme hypoxanthine–guanine phosphoribosyltransferase (HGprt). We generated 6 induced pluripotent stem c
Externí odkaz:
https://doaj.org/article/957b5bb790da4d86aa190f7843f35d1e
Publikováno v:
Neurobiology of Disease, Vol 166, Iss , Pp 105650- (2022)
This review provides an overview of the synaptic dysfunctions of neuronal circuits and underlying neurochemical alterations observed in the hyperkinetic movement disorders, dystonia and dyskinesia. These disorders exhibit similar changes in expressio
Externí odkaz:
https://doaj.org/article/f8a58e7b8878452f84d751e290d4f363
Autor:
Anthony M. Downs, Xueliang Fan, Radhika F. Kadakia, Yuping Donsante, H.A. Jinnah, Ellen J. Hess
Publikováno v:
Neurobiology of Disease, Vol 155, Iss , Pp 105369- (2021)
TOR1A-associated dystonia, otherwise known as DYT1 dystonia, is an inherited dystonia caused by a three base-pair deletion in the TOR1A gene (TOR1AΔE). Although the mechanisms underlying the dystonic movements are largely unknown, abnormalities in s
Externí odkaz:
https://doaj.org/article/1f0aea9f427b41ab97e4422a37d0b53d
Publikováno v:
Neurobiology of Disease, Vol 125, Iss , Pp 115-122 (2019)
Trihexyphenidyl, a nonselective muscarinic receptor antagonist, is the small molecule drug of choice for the treatment of DYT1 dystonia, but it is poorly tolerated due to significant side effects. A better understanding of the mechanism of action of
Externí odkaz:
https://doaj.org/article/42e940c5e75b42f6aa93993af421d915
Autor:
Kaitlyn M. Roman, Maria A. Briscione, Yuping Donsante, Jordan Ingram, Xueliang Fan, Douglas Bernhard, Simone A. Campbell, Anthony M. Downs, David Gutman, Tejas A. Sardar, Sofia Q. Bonno, Diane J. Sutcliffe, H.A. Jinnah, Ellen J. Hess
Publikováno v:
Neuroscience. 517:37-49
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03b78a90a47ed156dc384f9383788163
https://doi.org/10.1016/j.neuroscience.2023.02.020
https://doi.org/10.1016/j.neuroscience.2023.02.020
Autor:
Anthony M. Downs, Kaitlyn M. Roman, Simone A. Campbell, Antonio Pisani, Ellen J. Hess, Paola Bonsi
Publikováno v:
Neurobiology of Disease, Vol 130, Iss , Pp 104526- (2019)
Dystonia is a movement disorder characterized by involuntary muscle contractions, twisting movements, and abnormal postures that may affect one or multiple body regions. Dystonia is the third most common movement disorder after Parkinson’s disease
Externí odkaz:
https://doaj.org/article/6ba005aa808d42f49dc189e921c9ef0e
Autor:
Jerri M. Rook, Aaron M. Bender, Colleen M. Niswender, Yuping Donsante, P. Jeffrey Conn, Hyekyung P. Cho, Li Peng, Julie L. Engers, Jonathan W. Dickerson, Thomas M. Bridges, Craig W. Lindsley, Ellen J. Hess, Sichen Chang, Aidong Qi, Weimin Peng, Mark S. Moehle, Jordan C. O’Neill, Daniel J. Foster, Alice L. Rodriguez, Zoey Bryant, Katherine J. Watson, Kaylee J. Stillwell
Publikováno v:
ACS Pharmacology & Translational Science. 4:1306-1321
Nonselective antagonists of muscarinic acetylcholine receptors (mAChRs) that broadly inhibit all five mAChR subtypes provide an efficacious treatment for some movement disorders, including Parkinson's disease and dystonia. Despite their efficacy in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5425dfe0a6fb74da410878130ec6660
https://doi.org/10.1021/acsptsci.0c00162
https://doi.org/10.1021/acsptsci.0c00162
Publikováno v:
Tremor and Other Hyperkinetic Movements, Vol 7 (2017)
Background: The dystonias include a clinically and etiologically very diverse group of disorders. There are both degenerative and non-degenerative subtypes resulting from genetic or acquired causes. Traditionally, all dystonias have been viewed as di
Externí odkaz:
https://doaj.org/article/1b4cb816e1df4fa889542b995ea50ad7