Dietary protein sources differentially affect microbiota, mTOR activity and transcription of mTOR signaling pathways in the small intestine.

Autor: Soumya K Kar, Alfons J M Jansman, Nirupama Benis, Javier Ramiro-Garcia, Dirkjan Schokker, Leo Kruijt, Ellen H Stolte, Johanna J Taverne-Thiele, Mari A Smits, Jerry M Wells

Publikováno v: PLoS ONE, Vol 12, Iss 11, p e0188282 (2017)

Dietary protein sources can have profound effects on host-microbe interactions in the gut that are critically important for immune resilience. However more knowledge is needed to assess the impact of different protein sources on gut and animal health

Externí odkaz: https://doaj.org/article/46cd49f934ce45a388223980488aa1dc

Adjuvant Effect of Orally Applied Preparations Containing Non-Digestible Polysaccharides on Influenza Vaccination in Healthy Seniors: A Double-Blind, Randomised, Controlled Pilot Trial

Autor: Sophie Le Gall, Svein Halvor Knutsen, Ruwen Böhm, Angelika Pannenbeckers, Iris Pinheiro, Yala Stevens, Ellen H. Stolte, Sylvie van der Werf, Xavier Falourd, Catherine Stanton, Sam Possemiers, Jerry M. Wells, Monique van Erp, Simon Ballance, R. Paul Ross, Jurriaan J. Mes, Juergen Schrezenmeir, Edlyn Soeth, Ekaterina Papazova, Paul M. Ryan, C. Laue

Publikováno v: Nutrients
Nutrients, 2021, 13 (8), pp.2683. ⟨10.3390/nu13082683⟩
Nutrients 13 (2021) 8
Nutrients, MDPI, 2021, 13 (8), pp.2683. ⟨10.3390/nu13082683⟩
Nutrients, 13(8)
Nutrients, 13(8):2683. Multidisciplinary Digital Publishing Institute (MDPI)
Volume 13
Issue 8
Nutrients, Vol 13, Iss 2683, p 2683 (2021)

Senior individuals can suffer from immunosenescence and novel strategies to bolster the immune response could contribute to healthy ageing. In this double-blind, randomised, controlled pilot trial, we investigated the ability of non-digestible polysa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a83b1a6fa162f320ee32edd79c9ae534

Identification of Commensal Species Positively Correlated with Early Stress Responses to a Compromised Mucus Barrier

Autor: Bruno Sovran, Linda M. P. Loonen, Floor Hugenholtz, Paul de Vos, Michiel Kleerebezem, Jerry M. Wells, Clara Belzer, Ellen H. Stolte, Hauke Smidt, Peter van Baarlen, Mark V. Boekschoten, Peng Lu, Jan P. Dekker, Ingrid B. Renes

Publikováno v: Inflammatory Bowel Diseases, 22(4), 826-840. LIPPINCOTT WILLIAMS & WILKINS
Inflammatory Bowel Diseases, 22(4), 826-840
Inflammatory Bowel Diseases, 22(4), 826-840. Oxford University Press
Inflammatory bowel diseases, 22(4), 826-840. John Wiley and Sons Inc.
Inflammatory Bowel Diseases 22 (2016) 4

Background: Our aims were (1) to correlate changes in the microbiota to intestinal gene expression before and during the development of colitis in Muc2(-/-) mice and (2) to investigate whether the heterozygote Muc2(+/-) mouse would reveal host marker

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6a01855cda063979d7da31d71f34b71
https://doi.org/10.1097/mib.0000000000000688

Broadening the antibacterial spectrum of histidine kinase autophosphorylation inhibitors via the use of ε-poly-L-lysine capped mesoporous silica-based nanoparticles

Autor: Núria Mas, Lorena Polo, Jerry M. Wells, Ramón Martínez-Máñez, Rui Cao, Laura Miguel-Romero, Ellen H. Stolte, Alberto Marina, Nico Taverne, Nadya Velikova, José Ramón Murguía, Edoardo Zaccaria

Publikováno v: Nanomedicine: Nanotechnology, Biology and Medicine
Nanomedicine: Nanotechnology, Biology, and Medicine, 13(2), 569-581
Nanomedicine: Nanotechnology, Biology, and Medicine 13 (2017) 2
RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname

[EN] Two-component systems (TCS) regulate diverse processes such as virulence, stress responses, metabolism and antibiotic resistance in bacteria but are absent in humans, making them promising targets for novel antibacterials. By incorporating recen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c61dd68c009b41f1b7c461c45dbccd3

IL-22-STAT3 Pathway Plays a Key Role in the Maintenance of Ileal Homeostasis in Mice Lacking Secreted Mucus Barrier

Autor: Bruno Sovran, Jan P. Dekker, Peng Lu, Ingrid B. Renes, Paul de Vos, Floor Hugenholtz, Ellen H. Stolte, Michiel Kleerebezem, Peter van Baarlen, Linda M. P. Loonen, Jerry M. Wells, Mark V. Boekschoten, Clara Belzer

Publikováno v: Inflammatory Bowel Diseases, 21(3), 531-542. LIPPINCOTT WILLIAMS & WILKINS
Inflammatory Bowel Diseases 21 (2015) 3
Inflammatory Bowel Diseases, 21(3), 531-542
Inflammatory Bowel Diseases, 21(3), 531-542. Oxford University Press
Inflammatory bowel diseases, 21(3), 531-542. John Wiley and Sons Inc.

Background:Muc2-deficient mice show no signs of ileal pathology but the mechanisms remained unknown.Methods:Wild-type (WT), Muc2(+/-), and Muc2(-/-) mice were killed at 2, 4, and 8 weeks of age. Total RNA from ileum was used for full genome transcrip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5240f9d77153915d723707c7012f917
https://research.rug.nl/en/publications/df657268-49cb-42fa-bf43-12162325b04c