Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Ellen Gyssels"'
Publikováno v:
CHEMICAL COMMUNICATIONS
We here report on the design and synthesis of tailor-made furan-modified peptide nucleic acid (PNA) probes for covalent targeting of single stranded DNA through a crosslinking strategy. After introducing furan-containing building blocks into a PNA se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2b171f5901cf35baf06cb1005df49de
https://doi.org/10.1039/c6cc02062c
https://doi.org/10.1039/c6cc02062c
Autor:
Tomás Torres, Rudolf J. Schneider, Annemieke Madder, Henry Memczak, Cinthya Véliz Montes, Ellen Gyssels
Publikováno v:
Repositorio Institucional del Instituto Madrileño de Estudios Avanzados en Nanociencia
instname
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We report for the first time the formation of site specific interstrand cross p-linked (ICL) surface -immobilized furanmodified DNA duplexes-via singlet oxygen. 102, necessary for effecting furan-mediated ICL formation, was produced in situ using met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f339aff9a4f58b22d7c31894927b87f0
https://publica.fraunhofer.de/handle/publica/252091
https://publica.fraunhofer.de/handle/publica/252091
Publikováno v:
ChemInform. 47
Furan mediated nucleic acid cross-linking, initially developed for DNA interstrand duplex cross-linking, has matured into a versatile tool for the study of protein and nucleic acid interactions, ready to face its applications. The methodology was ini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79a2a40d41eaa1e6295f61642c07f2ff
https://doi.org/10.1002/chin.201611262
https://doi.org/10.1002/chin.201611262
Publikováno v:
Modified Nucleic Acids in Biology and Medicine ISBN: 9783319341736
This chapter contains an elaborate overview of various methods that have been developed for interstrand cross-linking of nucleic acids. The existing cross-link methodologies can be subcategorized in different groups, each interesting depending on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::918cfa6c9201294a7a1cc15a9f1d3c71
https://doi.org/10.1007/978-3-319-34175-0_15
https://doi.org/10.1007/978-3-319-34175-0_15
Publikováno v:
Chemical communications (Cambridge, England). 52(8)
Furan mediated nucleic acid cross-linking, initially developed for DNA interstrand duplex cross-linking, has matured into a versatile tool for the study of protein and nucleic acid interactions, ready to face its applications. The methodology was ini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e973d4eef90f041e40bcf44261b75f77
https://pubmed.ncbi.nlm.nih.gov/26679922
https://pubmed.ncbi.nlm.nih.gov/26679922
Publikováno v:
JOURNAL OF CHROMATOGRAPHY A
The stability of antisense oligonucleotides (ONs) toward nucleases is a key aspect for their possible implementation as therapeutic agents. Typically, ON stability studies are performed off-line, where the ONs are incubated with nucleases in solution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e42a1bab9491f2ebcc678ad11e0a9c64
https://pubmed.ncbi.nlm.nih.gov/26515385
https://pubmed.ncbi.nlm.nih.gov/26515385
Publikováno v:
Chembiochem : a European journal of chemical biology. 16(4)
Short oligonucleotides can selectively recognize duplexes by binding in the major groove thereby forming triplexes. Based on the success of our recently developed strategy for furan-based crosslinking in DNA duplexes, we here investigated for the fir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9430bc54526f4a4e47ca1a1fd64442d8
https://pubmed.ncbi.nlm.nih.gov/25630588
https://pubmed.ncbi.nlm.nih.gov/25630588
Publikováno v:
Collection Symposium Series.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8992d4c4ffd95e1baf2f3207f601c88e
https://doi.org/10.1135/css201414178
https://doi.org/10.1135/css201414178
Publikováno v:
Organicbiomolecular chemistry. 12(6)
We here report on the furan oxidation methodology for interstrand cross-linking of RNA duplexes, which have a different structure and are more stiff, reactive and labile than their DNA counterparts. Through this mildly inducible approach, natural unm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12bea135e806d29f2327bc469fd25843
https://pubmed.ncbi.nlm.nih.gov/24357353
https://pubmed.ncbi.nlm.nih.gov/24357353
Publikováno v:
Current Protocols in Nucleic Acid Chemistry
This unit describes a method for interstrand cross-linking between a furan-modified oligonucleotide and its unmodified complement. The synthesis of two furan-modified phosphoramidites, selected based on high cross-linking yield versus improved cross-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26b14c5ff620a841cc9b352b545000fa
https://doi.org/10.1002/0471142700.nc0512s54
https://doi.org/10.1002/0471142700.nc0512s54