Deep-coverage spatiotemporal proteome of the picoeukaryote Ostreococcus tauri reveals differential effects of environmental and endogenous 24-hour rhythms

Autor: Holly Kay, Ellen Grünewald, Helen K. Feord, Sergio Gil, Sew Y. Peak-Chew, Alessandra Stangherlin, John S. O’Neill, Gerben van Ooijen

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)

Holly Kay, Ellen Grünewald, et al. provide an in-depth examination of the proteome in the eukaryotic green alga, Ostreococcus tauri, under circadian constant light or cycling diurnal light-dark conditions. They observe that there is little overlap b

Externí odkaz: https://doaj.org/article/5d1cd59dcc7e47d8a24083d7cbcd5956

Differential effects of environmental and endogenous 24h rhythms within a deep-coverage spatiotemporal proteome

Autor: John S. O’Neill, Gerben van Ooijen, Alessandra Stangherlin, Helen K. Feord, Ellen Grünewald, Sew Y. Peak-Chew, Sergio Gil, Holly Kay

The cellular landscape of most eukaryotic cells changes dramatically over the course of a 24h day. Whilst the proteome responds directly to daily environmental cycles, it is also regulated by a cellular circadian clock that anticipates the differing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e454f3b2ea9ed7df59e2e64458f6135a
https://doi.org/10.1101/2021.03.30.437663

Methylation deficiency disrupts biological rhythms from bacteria to humans

Autor: Hitoshi Okamura, Jean-Michel Fustin, David Whitmore, Ellen Grünewald, Ryoichiro Kageyama, Maria Luísa Jabbur, Stephanie Tammam, Samantha J. Cargill, Marijke Versteven, Carl Hirschie Johnson, Melisa L. Lamberti, Christin Rakers, Kumiko Yoshioka-Kobayashi, P. Lynne Howell, Gerben van Ooijen, Diego A. Golombek, Takuya Matsuo, Rika Kojima, Ralf Stanewsky, Kensuke Kaneko, Kazuki Fukumoto, Shiqi Ye, Hideaki Kakeya, Yao Xu, Mayu Yamano, T. Katherine Tamai

Publikováno v: Fustin, J-M, Ye, S, Rakers, C, Kaneko, K, Fukumoto, K, Yamano, M, Versteven, M, Grünewald, E, Cargill, S J, Tamai, T K, Xu, Y, Jabbur, M L, Kojima, R, Lamberti, M L, Yoshioka-Kobayashi, K, Whitmore, D, Tammam, S, Howell, P L, Kageyama, R, Matsuo, T, Stanewsky, R, Golombek, D A, Johnson, C H, Kakeya, H, Ooijen, G V & Okamura, H 2020, ' Methylation deficiency disrupts biological rhythms from bacteria to humans ', Communications Biology, vol. 3, no. 1, 211 . https://doi.org/10.1038/s42003-020-0942-0
Communications Biology
Fustin, J-M, Ye, S, Rakers, C, Kaneko, K, Fukumoto, K, Yamano, M, Versteven, M, Grunewald, E, Cargill, S, Tamai, T K, Xu, Y, Jabbur, M L, Kojima, R, Lamberti, M L, Yoshioka Kobayashi, K, Whitmore, D, Tammam, S, Howell, P L, Kageyama, R, Matsuo, T, Stanewsky, R, Golombek, D A, Johnson, C H, Kakeya, H, Van Ooijen, G & Okamura, H 2020, ' Methylation deficiency disrupts biological rhythms from bacteria to humans ', Communications biology, vol. 3, no. 1, 211 . https://doi.org/10.1038/s42003-020-0942-0
Communications Biology, Vol 3, Iss 1, Pp 1-14 (2020)

The methyl cycle is a universal metabolic pathway providing methyl groups for the methylation of nuclei acids and proteins, regulating all aspects of cellular physiology. We have previously shown that methyl cycle inhibition in mammals strongly affec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99d6e5be01b1272356d531f73855b32e
https://doi.org/10.1038/s42003-020-0942-0

DISC1 regulates N-Methyl-D-Aspartate receptor dynamics: Abnormalities induced by a Disc1 mutation modelling a translocation linked to major mental illness

Autor: David J. Porteous, Mostafa Kabiri, Hazel Davidson-Smith, David Price, Marion Bonneau, Daniel L. McCartney, Miles D. Houslay, Paul Perry, J. Kirsty Millar, Kyriakos D. Economides, Shaun Mackie, Laura C. Murphy, Michel Didier, Fumiaki Ogawa, H. Greg Polites, Stephen M. Lawrie, Ellen Grünewald, Barbara Duff, Kathryn L. Evans, Colin A. Semple, Shane T. O’Sullivan, Darragh K. Crummie, Mandy Johnstone, Helen S. Torrance, Jonathan Phillips, Andrew M. McIntosh, Elise L.V. Malavasi, Philippe Gautier, Karen Burr, Costas Constantinides, Susan Anderson, Paraskevi Makedonopoulou, Siddharthan Chandran, Douglas Blackwood, Hannah Murdoch, Matthew Pearson

Publikováno v: Malavasi, E L V, Economides, K D, Grünewald, E, Makedonopoulou, P, Gautier, P, Mackie, S, Murphy, L C, Murdoch, H, Crummie, D, Ogawa, F, McCartney, D L, O'Sullivan, S T, Burr, K, Torrance, H S, Phillips, J, Bonneau, M, Anderson, S M, Perry, P, Pearson, M, Constantinides, C, Davidson-Smith, H, Kabiri, M, Duff, B, Johnstone, M, Polites, H G, Lawrie, S M, Blackwood, D H, Semple, C A, Evans, K L, Didier, M, Chandran, S, McIntosh, A M, Price, D J, Houslay, M D, Porteous, D J & Millar, J K 2018, ' DISC1 regulates N-methyl-D-aspartate receptor dynamics : abnormalities induced by a Disc1 mutation modelling a translocation linked to major mental illness ', Translational Psychiatry, vol. 8, no. 1, 184 . https://doi.org/10.1038/s41398-018-0228-1
Malavasi, E L V, Economides, K D, Grünewald, E, Makedonopoulou, P, Gautier, P, Mackie, S, Murphy, L C, Murdoch, H, Crummie, D, Ogawa, F, McCartney, D L, O’Sullivan, S T, Burr, K, Torrance, H S, Phillips, J, Bonneau, M, Anderson, S M, Perry, P, Pearson, M, Constantinides, C, Davidson-Smith, H, Kabiri, M, Duff, B, Johnstone, M, Polites, H G, Lawrie, S M, Blackwood, D H, Semple, C A, Evans, K L, Didier, M, Chandran, S, McIntosh, A M, Price, D J, Houslay, M D, Porteous, D J & Millar, J K 2018, ' DISC1 regulates N-methyl-D-aspartate receptor dynamics : abnormalities induced by a Disc1 mutation modelling a translocation linked to major mental illness ', Translational psychiatry, vol. 8, no. 1, 184 . https://doi.org/10.1038/s41398-018-0228-1
Translational Psychiatry
Translational Psychiatry, Vol 8, Iss 1, Pp 1-16 (2018)

The neuromodulatory gene DISC1 is disrupted by a t(1;11) translocation that is highly penetrant for schizophrenia and affective disorders, but how this translocation affects DISC1 function is incompletely understood. N-Methyl-D-Aspartate receptors (N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::870cbede3d419f12ab6663ee499dc410

Transplanted t(1;11) patient-derived OPCs form shorter myelin internodes in the hypomyelinated shiverer mice

Autor: David J. A. Wyllie, Siddharthan Chandran, Douglas Blackwood, Matthew R. Livesey, Steffen Mayerl, Samantha K. Barton, Ellen Grünewald, Pippa A. Thomson, Andrew M. McIntosh, Navneet A. Vasistha, Mandy Johnstone, David Story, J. Kirsty Millar, Charles ffrench-Constant, Kyriakos D. Economides, Karen Burr, Bhuvaneish T. Selvaraj, Clara Alloza, Dario Magnani, Paraskevi Makedonopolou, Stephen M. Lawrie, Mark E. Bastin, Giles E. Hardingham, Owen Dando

Publikováno v: Molecular Psychiatry. 24:1567-1567

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d7013edaf7d8de9e32648dbb2bc42360
https://doi.org/10.1038/s41380-019-0543-9