Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Ellen Gerhardt"'
Autor:
Marina I. Oliveira da Silva, Miguel Santejo, Isaac W. Babcock, Ana Magalhães, Laurie S. Minamide, Seok-Joon Won, Erika Castillo, Ellen Gerhardt, Christiane Fahlbusch, Raymond A. Swanson, Tiago F. Outeiro, Ricardo Taipa, Michael Ruff, James R. Bamburg, Márcia A. Liz
Publikováno v:
Cell Death and Disease, Vol 15, Iss 4, Pp 1-14 (2024)
Abstract Cognitive dysfunction and dementia are critical symptoms of Lewy Body dementias (LBD). Specifically, alpha-synuclein (αSyn) accumulation in the hippocampus leading to synaptic dysfunction is linked to cognitive deficits in LBD. Here, we inv
Externí odkaz:
https://doaj.org/article/1467f8fc03a64ff98e67847d4b3cd2df
Autor:
Laura Torres-Garcia, Joana M. P. Domingues, Edoardo Brandi, Caroline Haikal, Janitha M. Mudannayake, Inês C. Brás, Ellen Gerhardt, Wen Li, Alexander Svanbergsson, Tiago F. Outeiro, Gunnar K. Gouras, Jia-Yi Li
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Parkinson’s disease (PD) and Alzheimer’s disease (AD) are characterized by pathological accumulation and aggregation of different amyloidogenic proteins, α-synuclein (aSyn) in PD, and amyloid-β (Aβ) and Tau in AD. Strikingly, few PD a
Externí odkaz:
https://doaj.org/article/d99e8843f4304b3f85647c84f9bdbeaf
Autor:
Caterina Masaracchia, Marilena Hnida, Ellen Gerhardt, Tomás Lopes da Fonseca, Anna Villar-Pique, Tiago Branco, Markus A. Stahlberg, Camin Dean, Claudio O. Fernández, Ira Milosevic, Tiago F. Outeiro
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-17 (2018)
Abstract Alpha-synuclein (aSyn) plays a crucial role in Parkinson’s disease (PD) and other synucleinopathies, since it misfolds and accumulates in typical proteinaceous inclusions. While the function of aSyn is thought to be related to vesicle bind
Externí odkaz:
https://doaj.org/article/a7da468d38b3407296e6d3c18e9c26e7
Autor:
Éva M. Szegő, Antonio Dominguez-Meijide, Ellen Gerhardt, Annekatrin König, David J. Koss, Wen Li, Raquel Pinho, Christiane Fahlbusch, Mary Johnson, Patricia Santos, Anna Villar-Piqué, Tobias Thom, Silvio Rizzoli, Matthias Schmitz, Jiayi Li, Inga Zerr, Johannes Attems, Olaf Jahn, Tiago F. Outeiro
Publikováno v:
Cell Reports, Vol 28, Iss 1, Pp 65-77.e6 (2019)
Summary: Alpha-synuclein (aSyn) accumulates in intracellular inclusions in synucleinopathies, but the molecular mechanisms leading to disease are unclear. We identify the 10 kDa heat shock protein (HSP10) as a mediator of aSyn-induced mitochondrial i
Externí odkaz:
https://doaj.org/article/4a2e2c417fdf4144aa56a9b613fab5a7
Autor:
Rita Machado de Oliveira, Hugo Vicente Miranda, Laetitia Francelle, Raquel Pinho, Éva M Szegö, Renato Martinho, Francesca Munari, Diana F Lázaro, Sébastien Moniot, Patrícia Guerreiro, Luis Fonseca-Ornelas, Zrinka Marijanovic, Pedro Antas, Ellen Gerhardt, Francisco Javier Enguita, Bruno Fauvet, Deborah Penque, Teresa Faria Pais, Qiang Tong, Stefan Becker, Sebastian Kügler, Hilal Ahmed Lashuel, Clemens Steegborn, Markus Zweckstetter, Tiago Fleming Outeiro
Publikováno v:
PLoS Biology, Vol 15, Iss 4, p e1002601 (2017)
[This corrects the article DOI: 10.1371/journal.pbio.2000374.].
Externí odkaz:
https://doaj.org/article/fb415e7f10954b03bf291185f961cdfc
Autor:
Rita Machado de Oliveira, Hugo Vicente Miranda, Laetitia Francelle, Raquel Pinho, Éva M Szegö, Renato Martinho, Francesca Munari, Diana F Lázaro, Sébastien Moniot, Patrícia Guerreiro, Luis Fonseca-Ornelas, Zrinka Marijanovic, Pedro Antas, Ellen Gerhardt, Francisco Javier Enguita, Bruno Fauvet, Deborah Penque, Teresa Faria Pais, Qiang Tong, Stefan Becker, Sebastian Kügler, Hilal Ahmed Lashuel, Clemens Steegborn, Markus Zweckstetter, Tiago Fleming Outeiro
Publikováno v:
PLoS Biology, Vol 15, Iss 3, p e2000374 (2017)
Sirtuin genes have been associated with aging and are known to affect multiple cellular pathways. Sirtuin 2 was previously shown to modulate proteotoxicity associated with age-associated neurodegenerative disorders such as Alzheimer and Parkinson dis
Externí odkaz:
https://doaj.org/article/989eaa37ca2a44718ed354a73c818f4e
Autor:
Raquel Pinho, Leonor C Guedes, Lilach Soreq, Patrícia P Lobo, Tiago Mestre, Miguel Coelho, Mário M Rosa, Nilza Gonçalves, Pauline Wales, Tiago Mendes, Ellen Gerhardt, Christiane Fahlbusch, Vincenzo Bonifati, Michael Bonin, Gabriel Miltenberger-Miltényi, Fran Borovecki, Hermona Soreq, Joaquim J Ferreira, Tiago F Outeiro
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0190552 (2017)
[This corrects the article DOI: 10.1371/journal.pone.0157852.].
Externí odkaz:
https://doaj.org/article/2f2635697bb048799eacca685a327271
Autor:
Raquel Pinho, Leonor C Guedes, Lilach Soreq, Patrícia P Lobo, Tiago Mestre, Miguel Coelho, Mário M Rosa, Nilza Gonçalves, Pauline Wales, Tiago Mendes, Ellen Gerhardt, Christiane Fahlbusch, Vincenzo Bonifati, Michael Bonin, Gabriel Miltenberger-Miltényi, Fran Borovecki, Hermona Soreq, Joaquim J Ferreira, Tiago F Outeiro
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157852 (2016)
The prognosis of neurodegenerative disorders is clinically challenging due to the inexistence of established biomarkers for predicting disease progression. Here, we performed an exploratory cross-sectional, case-control study aimed at determining whe
Externí odkaz:
https://doaj.org/article/4732181b7c694ae1a30dc0768bd68d13
Publikováno v:
Neurobiology of Disease, Vol 45, Iss 1, Pp 591-600 (2012)
Parkinson's disease (PD) is the most common neurodegenerative movement disorder and is characterized by the loss of dopaminergic neurons from the substantia nigra pars compacta (SNpc). α-synuclein (αsyn) has been linked to the pathophysiology of PD
Externí odkaz:
https://doaj.org/article/7e4248a2322147028e8d14b00f81a5c9
Autor:
Guido Straten, Christian Schmeer, Alexandra Kretz, Ellen Gerhardt, Sebastian Kügler, Jörg B. Schulz, Claude Gravel, Mathias Bähr, Stefan Isenmann
Publikováno v:
Neurobiology of Disease, Vol 11, Iss 1, Pp 123-133 (2002)
Following transection of the optic nerve (ON) in the adult rat, retinal ganglion cells (RGCs) undergo degeneration, and within 14 days 85% of axotomized RGCs die by apoptosis. Adenoviral delivery of the mammalian caspase inhibitor X-chromosome-linked
Externí odkaz:
https://doaj.org/article/f54dbb76051244d1b560be297a2bf8da