Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Ellen G. McMahon"'
Publikováno v:
Mini-Reviews in Medicinal Chemistry. 5:709-718
Mineralocorticoid receptor (MR) antagonism has proven to effectively attenuate the pathophysiological effects of aldosterone in clinical and experimental settings of hypertension and heart failure. MR activates transcription of target genes upon aldo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5a14372e06dc45da56191724d06eb7e
https://doi.org/10.2174/1389557054553811
https://doi.org/10.2174/1389557054553811
Autor:
Anastassia Todor, Ellen G. McMahon, Sidney Goldstein, Hideaki Morita, Victor G. Sharov, George Suzuki, Elaine J. Tanhehco, Hani N. Sabbah, Amy E. Rudolph, Takayuki Mishima
Publikováno v:
Circulation. 106:2967-2972
Background— In heart failure (HF), aldosterone has been implicated in the formation of reactive interstitial fibrosis, a maladaptation that contributes to left ventricular (LV) remodeling. Eplerenone is a novel selective aldosterone blocker. The pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0319429a6271ca1dd5d14f4d3e832ebb
https://doi.org/10.1161/01.cir.0000039104.56479.42
https://doi.org/10.1161/01.cir.0000039104.56479.42
Autor:
Pochang Yang, Rachel Scherrer, John A. Delyani, Ricardo Rocha, Ellen G. McMahon, Cynthia L. Martin-Berger
Publikováno v:
Endocrinology. 143:4828-4836
We studied the role of aldosterone (aldo) in myocardial injury in a model of angiotensin (Ang) II-hypertension. Wistar rats were given 1% NaCl (salt) to drink and randomized into one of the following groups (n = 10; treatment, 21 d): 1) vehicle contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18fb577ad058d70b12bcb4b35b503f6f
https://doi.org/10.1210/en.2002-220120
https://doi.org/10.1210/en.2002-220120
Autor:
Ellen G. McMahon
Publikováno v:
Current Opinion in Pharmacology. 1:190-196
Activation of the renin–angiotensin–aldosterone system is associated with unsatisfactory outcomes in patients with hypertension and congestive heart failure, in that activation of this system is correlated strongly with both the incidence and ext
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9dfd1698ff298606fcdc58b12a0ee48
https://doi.org/10.1016/s1471-4892(01)00022-4
https://doi.org/10.1016/s1471-4892(01)00022-4
Autor:
Stuart A. Ross, Shaping Sun, Kay Broschat, Xiaoli Chen, Eric Arthur Gulve, Ellen G. Mcmahon, Heidi Rath Hope
Publikováno v:
Biochemical and Biophysical Research Communications. 273:1033-1041
Insulin resistance can be induced in vivo by intravenous infusion of glucosamine or in cells by incubation with glucosamine. However, a publication (Hresko, R. C., et al. (1998) J. Biol. Chem. 273, 20658-20668) suggests a trivial explanation of gluco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dc64ed62cfa0604b2a9eff6fdf68f57
https://doi.org/10.1006/bbrc.2000.3082
https://doi.org/10.1006/bbrc.2000.3082
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 275:E272-E277
Lithium has been shown to increase glucose uptake in skeletal muscle and adipose tissues. The therapeutic effect of lithium on bipolar disease is thought to be mediated by its inhibitory effect on myo-inositol-1-monophosphatase (IMPase). We tested th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d04f09e425639bb9c16581106dc0f568
https://doi.org/10.1152/ajpendo.1998.275.2.e272
https://doi.org/10.1152/ajpendo.1998.275.2.e272
Autor:
Maria A. Palomo, Gillian M. Olins, Ellen G. Mcmahon, Timothy S. Chamberlain, Susan T. Chen, Robert E. Manning, Edward H. Blaine, Horng-Chih Huang, Valerie M. Corpus
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:2591-2596
A series of potent, selective, conformationally restricted angiotensin II (AII) receptor antagonists has been discovered. Two classes of conformationally restricted analogues were prepared: triazolone-based and imidazole-based biphenyl derivatives. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fb81ff96344d8dd5b6ce0f581a326bf
https://doi.org/10.1016/s0960-894x(01)80290-0
https://doi.org/10.1016/s0960-894x(01)80290-0
Autor:
David B. Reitz, Ellen G. McMahon, Maria A. Palomo, Mark A. Penick, Gillian M. Olins, Brian Kai-Ming Cheng, Dean E. McGraw, Valerie M. Corpus, Emily J. Reinhard
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:99-104
Substituting nitrogen for carbon in the pyridinylphenylmethyl analogs of SC-50560 proved to be detrimental, however, the two phenylpyridinylmethyl analogs of SC-50560 retained their potencies. Of these two analogs, SC-52458 was found to have superior
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f40889f2e3d0a1f9d2774bd16683f67
https://doi.org/10.1016/s0960-894x(01)81129-x
https://doi.org/10.1016/s0960-894x(01)81129-x
Autor:
Maria A. Palomo, Ellen G. Mcmahon, Melanie A. Brown, Jeffery S. Carter, Stephen R. Bertenshaw
Publikováno v:
American Journal of Hypertension. 6:667-673
We reported previously that the endothelin converting enzyme (ECE) inhibitor phosphoramidon lowers mean arterial pressure (MAP) when infused in conscious, spontaneously hypertensive rats (SHRs). In this study we determined the dose-response relations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20124391ce04e0d1847d422ef600bb40
https://doi.org/10.1093/ajh/6.8.667
https://doi.org/10.1093/ajh/6.8.667
Autor:
Maria A. Palomo, Danny J. Garland, Konrad F. Koehler, David B. Reitz, Monica B. Norton, Emily J. Reinhard, Gillian M. Olins, Susan T. Chen, Robert E. Manning, J. T. Collins, Ellen G. McMahon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:1055-1060
The surmountable (competitive) N 1 -(2-methylphenyl)-2H-imidazol-2-one angiotensin II receptor antagonist SC-54628 is converted to an insurmountable (noncompetitive) antagonist SC-54629 by the addition of a methyl group at the 6-position of the pheny
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45e31096603038f887f225236b63745d
https://doi.org/10.1016/s0960-894x(00)80286-3
https://doi.org/10.1016/s0960-894x(00)80286-3