Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Ellen G. J. Hulskotte"'
Autor:
Joanna Udo de Haes, Marian Iwamoto, Azra Hussaini, Fang Liu, Carolyn R. Cho, Melissa Drexel, Sreeraj Macha, Bhavna Kantesaria, William L. Marshall, Heather R. Jordan, Arne van Schanke, Joan R. Butterton, Karsten Menzel, Ellen G. J. Hulskotte, Christine Tsai, Jacqueline B. McCrea
Publikováno v:
The Journal of Clinical Pharmacology. 58:897-904
Letermovir is a human cytomegalovirus terminase inhibitor for cytomegalovirus infection prophylaxis in hematopoietic stem cell transplant recipients. Posaconazole (POS), a substrate of glucuronosyltransferase and P-glycoprotein, and voriconazole (VRC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aef586af8a1dede86fb239dff6c0f509
https://doi.org/10.1002/jcph.1094
https://doi.org/10.1002/jcph.1094
Autor:
Edward O'Mara, Joan R. Butterton, Wen H. Lin, John A. Wagner, Hwa-Ping Feng, Lynn Webster, R. Douglas Bruce, Ellen G. J. Hulskotte, Feng Xuan
Publikováno v:
European Journal of Clinical Pharmacology. 71:303-311
Intravenous opioid use is a common route of hepatitis C virus (HCV) infection; consequently, the prevalence of HCV is high among patients on methadone or buprenorphine/naloxone. The authors evaluated the pharmacokinetic interaction of boceprevir with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::815f67b905cb79df66835bcb33752ba5
https://doi.org/10.1007/s00228-014-1789-4
https://doi.org/10.1007/s00228-014-1789-4
Autor:
Ellen G. J. Hulskotte, M. G. J. A. van Zutven, Edward O'Mara, Joan R. Butterton, Fengjuan Xuan, Samir Gupta, Hwa-Ping Feng, John A. Wagner
Publikováno v:
Antimicrobial Agents and Chemotherapy. 57:2582-2588
Boceprevir is a potent orally administered inhibitor of hepatitis C virus and a strong, reversible inhibitor of CYP3A4, the primary metabolic pathway for many 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors. Thus, the aim of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3df2781870ba90897ab285c3cf3272a
https://doi.org/10.1128/aac.02347-12
https://doi.org/10.1128/aac.02347-12
Autor:
Dirk, Kropeit, Jürgen, Scheuenpflug, Katharina, Erb-Zohar, Atef, Halabi, Hans-Peter, Stobernack, Ellen G J, Hulskotte, Arne, van Schanke, Holger, Zimmermann, Helga, Rübsamen-Schaeff
Publikováno v:
British journal of clinical pharmacology. 83(9)
Human cytomegalovirus remains a significant issue for immunocompromised patients and existing viral polymerase targeting therapies are associated with significant toxicity. Accordingly, the viral terminase complex inhibitor, letermovir, is in develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::422b2a0b9342a4696d33f51036c2b05d
https://pubmed.ncbi.nlm.nih.gov/28345163
https://pubmed.ncbi.nlm.nih.gov/28345163
Autor:
Ellen G. J. Hulskotte, Hwa-Ping Feng, E. Hughes, Stephen P. Youngberg, Fengjuan Xuan, Joan R. Butterton, Edward O'Mara, Marga G. J. A. van Zutven, M. Treitel, John A. Wagner
Publikováno v:
Clinical Infectious Diseases. 56:718-726
BACKGROUND Boceprevir represents a new treatment option for hepatitis C (HCV)-infected patients, including those with HCV/human immunodeficiency virus coinfection; however, little is known about pharmacokinetic interactions between boceprevir and ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c08d4328c5e6932654acfc35ea8d1794
https://doi.org/10.1093/cid/cis968
https://doi.org/10.1093/cid/cis968
Autor:
Ellen G. J. Hulskotte, Edward O'Mara, Fengjuan Xuan, Marga G. J. A. van Zutven, Samir Gupta, Joan R. Butterton, Hwa-Ping Feng, John A. Wagner
Publikováno v:
Hepatology. 56:1622-1630
The hepatitis C virus protease inhibitor boceprevir is a strong inhibitor of cytochrome P450 3A4 and 3A5 (CYP3A4/5). Cyclosporine and tacrolimus are calcineurin inhibitor immunosuppressants used to prevent organ rejection after liver transplantation;
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3a85c4068604a083ac08d31b3153c07
https://doi.org/10.1002/hep.25831
https://doi.org/10.1002/hep.25831
Publikováno v:
Clinical pharmacokinetics. 54(6)
Boceprevir is a potent, orally administered ketoamide inhibitor that targets the active site of the hepatitis C virus (HCV) non-structural (NS) 3 protease. The addition of boceprevir to peginterferon plus ribavirin resulted in higher rates of sustain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::291787497d2b74000f28372dadfe5316
https://pubmed.ncbi.nlm.nih.gov/25787025
https://pubmed.ncbi.nlm.nih.gov/25787025
Autor:
Larissa Rudenko, Pierre Van Damme, Theo Voeten, J.G.M. Heldens, Belinda Breedveld, Wilbert van Duijnhoven, Pierre Verweij, Han van den Bosch, Ellen G. J. Hulskotte
Publikováno v:
Vaccine
Live attenuated influenza vaccine (LAIV) offers the promise of inducing a variety of immune responses thereby conferring protection to circulating field strains. LAIVs are based on cold adapted and temperature sensitive phenotypes of master donor vir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39deeb4c64d7d049b43879054ad22141
https://pubmed.ncbi.nlm.nih.gov/24858566
https://pubmed.ncbi.nlm.nih.gov/24858566
Autor:
Cyrus Badshah, Joan R. Butterton, Carolyn R. Cho, Fang Liu, Joanna Udo de Haes, Walter K. Kraft, Francheska Colon-Gonzalez, Ellen G. J. Hulskotte, William L. Marshall, Bhavna Kantesaria, Eugene E. Marcantonio, Arne van Schanke
Publikováno v:
Biology of Blood and Marrow Transplantation. 21:S243
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a129fc281c0cd42cf38a3086ac2d952a
https://doi.org/10.1016/j.bbmt.2014.11.379
https://doi.org/10.1016/j.bbmt.2014.11.379