A Randomized Trial of Mesenchymal Stromal Cells for Moderate to Severe Acute Respiratory Distress Syndrome from COVID-19

Autor: Michael E. Bowdish, Christina E. Barkauskas, Jessica R. Overbey, Robert L. Gottlieb, Keren Osman, Abhijit Duggal, Mary E. Marks, Jonathan Hupf, Eustace Fernandes, Bradley G. Leshnower, Jonathan L. Golob, Alexander Iribarne, Athos J. Rassias, Ellen G. Moquete, Karen O’Sullivan, Helena L. Chang, Judson B. Williams, Sam Parnia, Nirav C. Patel, Nimesh D. Desai, Andrew M. Vekstein, Beth A. Hollister, Tammie Possemato, Christian Romero, Peter C. Hou, Elizabeth Burke, Jack Hayes, Fred Grossman, Silviu Itescu, Marc Gillinov, Francis D. Pagani, Patrick T. O’Gara, Michael J. Mack, Peter K. Smith, Emilia Bagiella, Alan J. Moskowitz, Annetine C. Gelijns

Publikováno v: American Journal of Respiratory and Critical Care Medicine. 207:261-270

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cc744b220025b12d465b16f20a8a502b
https://doi.org/10.1164/rccm.202201-0157oc

A Randomized Trial of Mesenchymal Stromal Cells for Moderate to Severe ARDS From COVID-19

Autor: Michael E, Bowdish, Christina E, Barkauskas, Jessica R, Overbey, Robert L, Gottlieb, Keren, Osman, Abhijit, Duggal, Mary E, Marks, Jonathan, Hupf, Eustace, Fernandes, Bradley G, Leshnower, Jonathan L, Golob, Alexander, Iribarne, Athos J, Rassias, Ellen G, Moquete, Karen, O'Sullivan, Helena L, Chang, Judson B, Williams, Sam, Parnia, Nirav C, Patel, Nimesh D, Desai, Andrew M, Vekstein, Beth A, Hollister, Tammie, Possemato, Christian, Romero, Peter C, Hou, Elizabeth, Burke, Jack, Hayes, Fred, Grossman, Silviu, Itescu, Marc, Gillinov, Francis D, Pagani, Patrick T, O'Gara, Michael J, Mack, Peter K, Smith, Emilia, Bagiella, Alan J, Moskowitz, Annetine C, Gelijns

Publikováno v: American journal of respiratory and critical care medicine.

There are limited therapeutic options for patients with COVID-19-related acute respiratory distress syndrome (ARDS) with inflammation-mediated lung injury. Mesenchymal stromal cells offer promise as immunomodulatory agents.Evaluation of efficacy and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::50548bebd758b1bbe5e39a81b14d6f04
https://pubmed.ncbi.nlm.nih.gov/36099435

Cost-Effectiveness of Mitral Valve Repair Versus Replacement for Severe Ischemic Mitral Regurgitation: A Randomized Clinical Trial From the Cardiothoracic Surgical Trials Network

Autor: Bart S., Ferket, Gorav, Ailawadi, Annetine C., Gelijns, Michael, Acker, Samuel F., Hohmann, Helena L., Chang, Denis, Bouchard, David O., Meltzer, Robert E., Michler, Ellen G., Moquete, Pierre, Voisine, John C., Mullen, Anuradha, Lala, Michael J., Mack, A. Marc, Gillinov, Vinod H., Thourani, Marissa A., Miller, James S., Gammie, Michael K., Parides, Emilia, Bagiella, Robert L., Smith, Peter K., Smith, Judy W., Hung, Lopa N., Gupta, Eric A., Rose, Patrick T., O'Gara, Alan J., Moskowitz, Cardiothoracic Surgical Trials Network (CTSN) Investigators

Publikováno v: Circulation. Cardiovascular quality and outcomes. 11(11)

The CTSN (Cardiothoracic Surgical Trials Network) recently reported no difference in left ventricular end-systolic volume index or in survival at 2 years between patients with severe ischemic mitral regurgitation (MR) randomized to mitral valve repai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::aa169b3a13108c6903faab98778a0f21
https://pubmed.ncbi.nlm.nih.gov/30571341

Mitral-Valve Repair versus Replacement for Severe Ischemic Mitral Regurgitation

Autor: Michael A, Acker, Michael K, Parides, Louis P, Perrault, Alan J, Moskowitz, Annetine C, Gelijns, Pierre, Voisine, Peter K, Smith, Judy W, Hung, Eugene H, Blackstone, John D, Puskas, Michael, Argenziano, James S, Gammie, Michael, Mack, Deborah D, Ascheim, Emilia, Bagiella, Ellen G, Moquete, T Bruce, Ferguson, Keith A, Horvath, Nancy L, Geller, Marissa A, Miller, Y Joseph, Woo, David A, D'Alessandro, Gorav, Ailawadi, Francois, Dagenais, Timothy J, Gardner, Patrick T, O'Gara, Robert E, Michler, Irving L, Kron, Mary N, Walsh

Publikováno v: New England Journal of Medicine. 370:23-32

Ischemic mitral regurgitation is associated with a substantial risk of death. Practice guidelines recommend surgery for patients with a severe form of this condition but acknowledge that the supporting evidence for repair or replacement is limited.We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a629f13a5918b0498cbf2147b27f88e
https://doi.org/10.1056/nejmoa1312808

Surgical treatment of moderate ischemic mitral regurgitation

Autor: Peter K, Smith, John D, Puskas, Deborah D, Ascheim, Pierre, Voisine, Annetine C, Gelijns, Alan J, Moskowitz, Judy W, Hung, Michael K, Parides, Gorav, Ailawadi, Louis P, Perrault, Michael A, Acker, Michael, Argenziano, Vinod, Thourani, James S, Gammie, Marissa A, Miller, Pierre, Pagé, Jessica R, Overbey, Emilia, Bagiella, François, Dagenais, Eugene H, Blackstone, Irving L, Kron, Daniel J, Goldstein, Eric A, Rose, Ellen G, Moquete, Neal, Jeffries, Timothy J, Gardner, Patrick T, O'Gara, John H, Alexander, Robert E, Michler, Yanne, Toulgoat-Dubois

Publikováno v: Smith, P K, Puskas, J D, Ascheim, D D, Voisine, P, Gelijns, A C, Moskowitz, A J, Hung, J W, Parides, M K, Ailawadi, G, Perrault, L P, Acker, M A, Argenziano, M, Thourani, V, Gammie, J S, Miller, M A, Pagé, P, Overbey, J R, Bagiella, E, Dagenais, F, Blackstone, E H, Kron, I L, Goldstein, D J, Rose, E A, Moquete, E G, Jeffries, N, Gardner, T J, O'Gara, P T, Alexander, J H, Michler, R E & Cardiothoracic Surgical Trials Network Investigators (Sten Lyager Nielsen) 2014, ' Surgical treatment of moderate ischemic mitral regurgitation ', The New England Journal of Medicine, vol. 371, no. 23, pp. 2178-88 . https://doi.org/10.1056/NEJMoa1410490

BACKGROUND: Ischemic mitral regurgitation is associated with increased mortality and morbidity. For surgical patients with moderate regurgitation, the benefits of adding mitral-valve repair to coronary-artery bypass grafting (CABG) are uncertain.METH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a21fbb5ae6ecd2ae573b785e87428f74
https://pubmed.ncbi.nlm.nih.gov/26086049