Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Ellen Freed"'
Autor:
Benoit Souquet, Ellen Freed, Alessandro Berto, Vedrana Andric, Nicolas Audugé, Bernardo Reina-San-Martin, Elizabeth Lacy, Valérie Doye
Publikováno v:
Cell Reports, Vol 23, Iss 8, Pp 2443-2454 (2018)
Summary: Nup133 belongs to the Y-complex, a key component of the nuclear pore complex (NPC) scaffold. Studies on a null mutation in mice previously revealed that Nup133 is essential for embryonic development but not for mouse embryonic stem cell (mES
Externí odkaz:
https://doaj.org/article/a2307bf7c7884691abc72400fd4b59b8
Autor:
Patricia Ellen Freed
Publikováno v:
PsycCRITIQUES. 62
Autor:
Ellen Freed
Publikováno v:
Nursing standard (Royal College of Nursing (Great Britain) : 1987). 23(23)
American talk show host Oprah Winfrey has again put on weight and says she is furious with herself (reflections February 4). She has gained and lost weight in the public eye for a number of years.
Autor:
Ellen Freed, Lucienne Ronco, Timothy Pontz, Patrick Brassil, Haiqing Hu, Xiaolan Zheng, Muthusamy Jayaraman, Davies Audrey, Lillian Castriotta, Dennis Huszar, Maria-Elena Theoclitou, Murali V P Nadella, Daniel John Russell, Brian Aquila, Michael Collins, Vibha Oza, David Whitston, Tracy L. Deegan, Michael Howard Block, Deborah Lawson, Sandra Filla, Maniyan Padmanilayam, Erin Code, Paula Lewis, Jayachandran Ezhuthachan
Publikováno v:
Journal of Medicinal Chemistry. 54:6734-6750
Structure-activity relationship analysis identified (+)-N-(3-aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), from a series of novel kinesin spindle protein (KSP) inhibitors,
Autor:
Ellen Freed, Jurian Schuijers, Rita Sulahian, Hyunjin Shin, Michael P. Verzi, Hans Clevers, Pantelis Hatzis, X. Shirley Liu, Juliet Philips, John P. Lynch, Myles Brown, Ramesh A. Shivdasani, Duyen T. Dang
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 107(34), 15157-15162. National Academy of Sciences
Surprisingly few pathways signal between cells, raising questions about mechanisms for tissue-specific responses. In particular, Wnt ligands signal in many mammalian tissues, including the intestinal epithelium, where constitutive signaling causes ca
Autor:
Ellen Freed, Massimo Loda, Stephen P. Finn, Jordi Barretina, Natalie Vena, Craig H. Mermel, Jennifer Ang Chan, Ian F. Dunn, Ramesh A. Shivdasani, William C. Hahn, José Baselga, Supriya Rani Jain, Milan G. Chheda, Azra H. Ligon, David E. Root, Yashaswi Shrestha, Charles S. Fuchs, Pablo Tamayo, Jesse S. Boehm, Isil Guney, Emeric Bojarski, Matthew Meyerson, Shuji Ogino, So Young Kim, Adam J. Bass, Serena J. Silver, Ron Firestein, Josep Tabernero
Publikováno v:
Nature. 455:547-551
Aberrant activation of the canonical WNT/beta-catenin pathway occurs in almost all colorectal cancers and contributes to their growth, invasion and survival. Although dysregulated beta-catenin activity drives colon tumorigenesis, further genetic pert
Autor:
Peter K. Jackson, Adam G. Eldridge, Brett K. Kaiser, Julie D.R. Reimann, Jerry Y. Hsu, Laura Furstenthal, Ellen Freed
Publikováno v:
Trends in Cell Biology. 10:429-439
Recently, many new examples of E3 ubiquitin ligases or E3 enzymes have been found to regulate a host of cellular processes. These E3 enzymes direct the formation of multiubiquitin chains on specific protein substrates, and - typically - the subsequen
Autor:
Joanne Dahme, Claire Donato, Victoria Prizzia, Ellen Freedman Schultz, Theresa R. Stuhlman, Karen Young
Publikováno v:
Blue Papers, Vol 1, Iss 1 (2022)
The Fairmount Water Works of Philadelphia has many stories to tell that span its rich 200-year history. It speaks to the history of technology in America, urban water systems, public health and civic architecture. Although struggling with the increas
Externí odkaz:
https://doaj.org/article/c3f2b4aca568444d84b558f2b4608e41
Publikováno v:
Science. 265:1713-1716
To identify proteins that may participate in the activation of the protein kinase Raf, proteins that interact with Raf were selected in a two-hybrid screen. Two members of the 14-3-3 protein family were isolated that interacted with both the amino te
Autor:
Jonathan S. Silver, M Silver, S Marwah, Maria Tzardi, John Souglakos, Shuji Ogino, Dianne M. Finkelstein, V. Georgoulias, Rui Wang, Susanne M. Hooshmand, Z. Saridaki, Charles S. Fuchs, Matthew H. Kulke, Ramesh A. Shivdasani, Juliet Philips, Jeffrey A. Meyerhardt, Ellen Freed, Eunice L. Kwak
Publikováno v:
British Journal of Cancer
Background: We address the prognostic and predictive value of KRAS, PIK3CA and BRAF mutations for clinical outcomes in response to active agents in the treatment of metastatic colorectal cancer (mCRC). Methods: We determined KRAS, BRAF and PIK3CA mut